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Chemical Compound Review

Butalex     4-hydroxy-3-[(4-tert- butylcyclohexyl)methy...

Synonyms: Buparvacuona, Buparvaquone, Buparvaquonum, SureCN22978, CHEMBL292009, ...
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Disease relevance of BW 720C

  • In addition, 4b easily released the parent drug in human skin homogenate and, therefore, is a promising prodrug candidate to deliver buparvaquone through the skin for the treatment of cutaneous leishmaniasis [1].
  • Water-soluble phosphate prodrugs of buparvaquone (1), containing a hydroxynaphthoquinone structure, were synthesized and evaluated in vitro for improved topical and oral drug delivery against cutaneous and visceral leishmaniasis [1].
  • As a result of a theileriosis problem at about day 60 after inoculation in 2 cattle given 10(-2) dilution of stabilate and buparvaquone treatment on day 0, an additional 5 cattle were given 10(-2) dilution of stabilate and developed a good immunity after buparaquone treatment [2].
  • Groups of 3 cattle infected with 1 ml inocula at 10(0), 10(-1) and 10(-2) dilutions were treated with 2.5 mg/kg body weight of buparvaquone on day 0 and similar groups were left untreated to act as controls [2].
  • When administered at the rate of 5 mg/kg of body weight, IV, 4 times at 48-hour intervals, buparvaquone prompted rapid abatement of parasitemia [3].

High impact information on BW 720C


Chemical compound and disease context of BW 720C


Biological context of BW 720C


Anatomical context of BW 720C


Associations of BW 720C with other chemical compounds

  • 4. The prodrugs 2b, 3b and 5b rapidly released (t1/2 = 7 min) the corresponding oximes of buparvaquone (1a and 1b), and prodrug 4b at a moderate rate (t1/2 = 22.5 min) in alkaline phosphatase solution in vitro [14].
  • Elimination of Theileria buffeli infections from cattle by concurrent treatment with buparvaquone and primaquine phosphate [17].

Gene context of BW 720C


Analytical, diagnostic and therapeutic context of BW 720C


  1. Synthesis, in vitro evaluation, and antileishmanial activity of water-soluble prodrugs of buparvaquone. Mäntylä, A., Garnier, T., Rautio, J., Nevalainen, T., Vepsälainen, J., Koskinen, A., Croft, S.L., Järvinen, T. J. Med. Chem. (2004) [Pubmed]
  2. Immunization of cattle using varying infective doses of Theileria parva lawrencei sporozoites derived from an African buffalo (Syncerus caffer) and treatment with buparvaquone. Mutugi, J.J., Young, A.S., Maritim, A.C., Linyonyi, A., Mbogo, S.K., Leitch, B.L. Parasitology (1988) [Pubmed]
  3. Efficacy of buparvaquone as a therapeutic and clearing agent of Babesia equi of European origin in horses. Zaugg, J.L., Lane, V.M. Am. J. Vet. Res. (1992) [Pubmed]
  4. In vivo monitoring of intracellular ATP levels in Leishmania donovani promastigotes as a rapid method to screen drugs targeting bioenergetic metabolism. Luque-Ortega, J.R., Rivero-Lezcano, O.M., Croft, S.L., Rivas, L. Antimicrob. Agents Chemother. (2001) [Pubmed]
  5. Bovine gammadelta T-cell responses to the intracellular protozoan parasite Theileria parva. Daubenberger, C.A., Taracha, E.L., Gaidulis, L., Davis, W.C., McKeever, D.J. Infect. Immun. (1999) [Pubmed]
  6. The activity of hydroxynaphthoquinones against Leishmania donovani. Croft, S.L., Hogg, J., Gutteridge, W.E., Hudson, A.T., Randall, A.W. J. Antimicrob. Chemother. (1992) [Pubmed]
  7. Apoptosis of Theileria-infected lymphocytes induced upon parasite death involves activation of caspases 9 and 3. Guergnon, J., Dessauge, F., Langsley, G., Garcia, A. Biochimie (2003) [Pubmed]
  8. Treatment of East Coast fever: a comparison of parvaquone and buparvaquone. Muraguri, G.R., Kiara, H.K., McHardy, N. Vet. Parasitol. (1999) [Pubmed]
  9. Treatment of theileriosis in crossbred cattle in the Punjab. Singh, J., Gill, J.S., Kwatra, M.S., Sharma, K.K. Tropical animal health and production. (1993) [Pubmed]
  10. Detection of Theileria annulata by the PCR in ticks (Acari:Ixodidae) collected from cattle in Mauritania. d'Oliveira, C., van der Weide, M., Jacquiet, P., Jongejan, F. Exp. Appl. Acarol. (1997) [Pubmed]
  11. Evaluation of buparvaquone (BUTA-Kel KELA, Belgium) as a treatment of East Coast fever in cattle, in the peri-urban of Dar Es Salaam city, Tanzania. Mbwambo, H.A., Magwisha, H.B., Mfinanga, J.M. Vet. Parasitol. (2006) [Pubmed]
  12. Parvaquone and buparvaquone: HPLC analysis and comparative pharmacokinetics in cattle. Kinabo, L.D., Bogan, J.A. Acta Trop. (1988) [Pubmed]
  13. The effect of buparvaquone treatment on the levels of some antioxidant vitamins, lipid peroxidation and glutathione peroxidase in cattle with theileriosis. Naziroğlu, M., Saki, C.E., Sevgili, M. Zentralblatt Veterinarmedizin Reihe B (1999) [Pubmed]
  14. Design, synthesis and in vitro evaluation of novel water-soluble prodrugs of buparvaquone. Mäntylä, A., Rautio, J., Nevalainen, T., Keski-Rahkonen, P., Vepsälainen, J., Järvinen, T. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (2004) [Pubmed]
  15. Activity of buparvaquone against Theileria cervi in white-tailed deer. Mitema, E.S., Kocan, A.A., Mukolwe, S.W., Sangiah, S., Sherban, D. Vet. Parasitol. (1991) [Pubmed]
  16. Buparvaquone but not cyclosporin A prevents Theileria annulata-infected bovine lymphoblastoid cells from stimulating uninfected lymphocytes. Rintelen, M., Schein, E., Ahmed, J.S. Trop. Med. Parasitol. (1990) [Pubmed]
  17. Elimination of Theileria buffeli infections from cattle by concurrent treatment with buparvaquone and primaquine phosphate. Stewart, N.P., de Vos, A.J., McHardy, N., Standfast, N.F. Tropical animal health and production. (1990) [Pubmed]
  18. Effect of buparvaquone on the expression of interleukin 2 receptors in Theileria annulata-infected cells. Ahmed, J.S., Rintelen, M., Schein, E., Williams, R.O., Dobbelaere, D. Parasitol. Res. (1992) [Pubmed]
  19. Characterization of nebulized buparvaquone nanosuspensions--effect of nebulization technology. Hernández-Trejo, N., Kayser, O., Steckel, H., Müller, R.H. Journal of drug targeting. (2005) [Pubmed]
  20. Chemotherapy of Theileria annulata infection with buparvaquone. Dhar, S., Malhotra, D.V., Bhushan, C., Gautam, O.P. Vet. Rec. (1986) [Pubmed]
  21. Chemoprophylaxis of Theileria annulata and Theileria parva infections of calves with buparvaquone. Wilkie, G.M., Brown, C.G., Kirvar, B.E., Thomas, M., Williamson, S.M., Bell-Sakyi, L.J., Sparagano, O. Vet. Parasitol. (1998) [Pubmed]
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