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Chemical Compound Review

Hostetex L-pec     1,2,4-trichlorobenzene

Synonyms: SureCN22730, CHEMBL296348, ACMC-1B7LJ, CCRIS 5945, LS-638, ...
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Disease relevance of Hostetex L-pec


High impact information on Hostetex L-pec

  • The proposed mechanism of enzymatic biotransformation of gamma-HCH to 1,2,4-TCB by LinA consists of two 1,2-anti conformationally dependent dehydrochlorinations followed by 1,4-anti dehydrochlorination [6].
  • Different (13)C NMR methods of determining triad distributions in two poly(ethylene-co-1-hexene) copolymers are examined using high signal-to-noise ratio (13)C NMR spectra of the copolymers dissolved in deuterated 1,2,4-trichlorobenzene at 398 K [7].
  • This transition from the first-order kinetics at low initial 1,2,4-TCB concentrations to the second first-order kinetics at higher 1,2,4-TCB concentrations was shifted towards higher initial 1,2,4-TCB concentrations with increasing cell mass [2].
  • This was confirmed by gas chromatography-mass spectrometry analyses showing that degradation subproducts of gamma-HCH included an unidentified tetrachlorinated compound and subsequently 1,2,4-trichlorobenzene and 2,5-dichlorophenol [8].
  • An experimentally practical and precise flocculation-based method was developed, tested, and applied to determine phenanthrene and 1,2,4-trichlorobenzene sorption with NIST SRM 2975 diesel particulate matter [9].

Chemical compound and disease context of Hostetex L-pec

  • The capacity of the beta-Proteobacterium Pseudomonas sp. strain P51, which degrades chlorinated benzenes, to metabolize 1,2,4-trichlorobenzene (TCB) under environmental conditions was tested by its release into two experimental systems [10].

Biological context of Hostetex L-pec


Anatomical context of Hostetex L-pec

  • The time courses of increasing of hepatic microsomal total cytochrome P450 content after a single i.p. administration of 1,2,4-TCB (1.36 mmol/kg), and 2,3,5- and 2,4,5-trichlorophenyl methyl sulfones (2,3,5- and 2,4,5-TCPSO2Mes) (50 micromol/kg each) were in parallel with those of increasing of the total heme content in liver microsomes [16].

Associations of Hostetex L-pec with other chemical compounds


Gene context of Hostetex L-pec

  • Linear polyethylene standards in the range of 1-500 kg/mol, dissolved in 1,2,4-trichlorobenzene, were injected into a column packed with oligo(dimethylsiloxane) modified silica gel [21].
  • 1,2,4-TCB significantly increased the heme oxygenase activity, but 2,3,5- and 2,4,5-TCPSO2Mes did not [16].

Analytical, diagnostic and therapeutic context of Hostetex L-pec


  1. Cloning and characterization of plasmid-encoded genes for the degradation of 1,2-dichloro-, 1,4-dichloro-, and 1,2,4-trichlorobenzene of Pseudomonas sp. strain P51. van der Meer, J.R., van Neerven, A.R., de Vries, E.J., de Vos, W.M., Zehnder, A.J. J. Bacteriol. (1991) [Pubmed]
  2. Multiphasic kinetics of transformation of 1,2,4-trichlorobenzene at nano- and micromolar concentrations by Burkholderia sp. strain PS14. Rapp, P. Appl. Environ. Microbiol. (2001) [Pubmed]
  3. The chlorocatechol-catabolic transposon Tn5707 of Alcaligenes eutrophus NH9, carrying a gene cluster highly homologous to that in the 1,2,4-trichlorobenzene-degrading bacterium Pseudomonas sp. strain P51, confers the ability to grow on 3-chlorobenzoate. Ogawa, N., Miyashita, K. Appl. Environ. Microbiol. (1999) [Pubmed]
  4. Modulation of halobenzene-induced hepatotoxicity by DT-diaphorase modulators, butylated hydroxyanisole and dicoumarol: evidence for possible involvement of quinone metabolites in the toxicity of halobenzenes. Mizutani, T., Miyamoto, Y. Toxicol. Lett. (1999) [Pubmed]
  5. Repeated topical applications of 1,2,4-trichlorobenzene. Effects on rabbit ears. Powers, M.B., Coate, W.B., Lewis, T.R. Arch. Environ. Health (1975) [Pubmed]
  6. Reaction mechanism and stereochemistry of gamma-hexachlorocyclohexane dehydrochlorinase LinA. Trantírek, L., Hynková, K., Nagata, Y., Murzin, A., Ansorgová, A., Sklenár, V., Damborský, J. J. Biol. Chem. (2001) [Pubmed]
  7. Quantitative 13C NMR analysis of sequence distributions in poly(ethylene-co-1-hexene). Seger, M.R., Maciel, G.E. Anal. Chem. (2004) [Pubmed]
  8. Isolation and characterization of a novel gamma-hexachlorocyclohexane-degrading bacterium. Thomas, J.C., Berger, F., Jacquier, M., Bernillon, D., Baud-Grasset, F., Truffaut, N., Normand, P., Vogel, T.M., Simonet, P. J. Bacteriol. (1996) [Pubmed]
  9. Sorption nonlinearity for organic contaminants with diesel soot: method development and isotherm interpretation. Nguyen, T.H., Sabbah, I., Ball, W.P. Environ. Sci. Technol. (2004) [Pubmed]
  10. Population dynamics of an introduced bacterium degrading chlorinated benzenes in a soil column and in sewage sludge. Tchelet, R., Meckenstock, R., Steinle, P., van der Meer, J.R. Biodegradation (1999) [Pubmed]
  11. Transcriptional activation of the chlorocatechol degradative genes of Ralstonia eutropha NH9. Ogawa, N., McFall, S.M., Klem, T.J., Miyashita, K., Chakrabarty, A.M. J. Bacteriol. (1999) [Pubmed]
  12. Relative contributions of aqueous and dietary uptake of hydrophobic chemicals to the body burden in juvenile rainbow trout. Qiao, P., Gobas, F.A., Farrell, A.P. Arch. Environ. Contam. Toxicol. (2000) [Pubmed]
  13. Chronic, inhalation exposure of rats, rabbits, and monkeys to 1,2,4-trichlorobenzene. Coate, W.B., Lewis, R., Busey, W.M., Schoenfisch, W.H. Arch. Environ. Health (1977) [Pubmed]
  14. Maternal hepatic and embryonic effects of 1,2,4-trichlorobenzene in the rat. Kitchin, K.T., Ebron, M.T. Environmental research. (1983) [Pubmed]
  15. 1,2,4-Trichlorobenzene induction of chromosomal aberrations and cell division of root-tip cells in Vicia faba seedlings. Liu, W., Zhou, Q.X., Li, P.J., Sun, T.H., Yang, Y.S., Xiong, X.Z. Bulletin of environmental contamination and toxicology. (2003) [Pubmed]
  16. The contribution of 2,3,5-trichlorophenyl methyl sulfone, a metabolite of 1,2,4-trichlorobenzene, to the delta-aminolevulinic acid synthetase induction by 1,2,4-trichlorobenzene in rat liver. Kato, Y., Kimura, R. Chemosphere (2002) [Pubmed]
  17. Solvent dependence of the structure and magnetic ordering of ferrimagnetic manganese(III) meso-tetraphenylporphyrin tetracyanoethenide, [MnTPP]+[TCNE]*-. Hibbs, W., Rittenberg, D.K., Sugiura , K., Burkhart, B.M., Morin, B.G., Arif, A.M., Liable-Sands, L., Rheingold, A.L., Sundaralingam, M., Epstein, A.J., Miller, J.S. Inorganic chemistry. (2001) [Pubmed]
  18. Human cytochrome P450 enzyme selectivities in the oxidation of chlorinated benzenes. Bogaards, J.J., van Ommen, B., Wolf, C.R., van Bladeren, P.J. Toxicol. Appl. Pharmacol. (1995) [Pubmed]
  19. Sorption of apolar aromatic compounds to soil humic acid particles affected by aluminum(III) ion Cross-Linking. Lu, Y., Pignatello, J.J. J. Environ. Qual. (2004) [Pubmed]
  20. Modeling response of species to microcontaminants: comparative ecotoxicology by (sub)lethal body burdens as a function of species size and partition ratio of chemicals. Hendriks, A.J. Ecotoxicol. Environ. Saf. (1995) [Pubmed]
  21. Elution behavior of polyethylene in polar mobile phases on a non-polar sorbent. Macko, T., Pasch, H., Kazakevich, Y.V., Fadeev, A.Y. Journal of chromatography. A. (2003) [Pubmed]
  22. Quantification of bacterial mRNA involved in degradation of 1,2,4-trichlorobenzene by Pseudomonas sp. strain P51 from liquid culture and from river sediment by reverse transcriptase PCR (RT/PCR). Meckenstock, R., Steinle, P., van der Meer, J.R., Snozzi, M. FEMS Microbiol. Lett. (1998) [Pubmed]
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