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Gene Review

USP39  -  ubiquitin specific peptidase 39

Homo sapiens

Synonyms: 65K, CGI-21, HSPC332, Inactive ubiquitin-specific peptidase 39, PRO2855, ...
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Disease relevance of USP39


High impact information on USP39

  • This line showed a specific proliferative response to PPD and to a recombinant mycobacterial heat-shock protein (HSP) of relative molecular mass 65,000 (65K) [5].
  • The AChR from the electroplax of the ray Torpedo californica consists of five subunits present in a molar stoichiometry of alpha 2 beta gamma delta (refs 4-6); the apparent molecular weights of the alpha-, beta-, gamma- and delta-subunits are 40,000 (40K), 50K, 60K and 65K, respectively [6].
  • We provide evidence that, in contrast to the previously published U12 snRNA secondary structure model, the 3' half of U12 forms an extended stem-loop with a highly conserved seven-nucleotide loop and that the latter serves as the 65K binding site [7].
  • In earlier work, we showed that Sad1, the gene encoding the first committed enzyme in the avenacin pathway (beta-amyrin synthase), had arisen by duplication and divergence of a cycloartenol synthase-like gene [8].
  • Significantly, the major tri-snRNP-specific proteins 65K and 110K, which are required for integration of the major tri-snRNP into the U2-dependent spliceosome, were among those proteins detected in the minor tri-snRNP, raising an interesting question as to how the specificity of addition of tri-snRNP to the corresponding spliceosome is maintained [9].

Chemical compound and disease context of USP39

  • All four FcRs were reactive with a murine monoclonal antibody to herpes simplex virus glycoprotein E. Anti-HCMV antibodies markedly inhibited the binding of 125I-labelled human IgG Fc to the 130K and 50K species but inhibited to a lesser extent the binding to the 65K FcR [10].

Biological context of USP39

  • In studies with synthetic oligodeoxynucleotides homologous to leader RNA sequences, only those oligonucleotides containing the inhibitory sequence were able to bind to a gradient fraction containing the 65K protein [1].
  • Pulse-chase experiments and experiments with monensin as an inhibitor of glycosylation suggested that the 120K polypeptide was derived by glycosylation of the 118K polypeptide and that a 43K antigen was processed into the 64 to 65K glycoprotein [11].
  • The identification of a 65K protein among products synthesized in vitro suggests that this protein may be identical to the 65K major T antigen present in adenovirus type 5-infected and -transformed cells, and this indicates that it is indeed encoded by the viral genome [4].

Anatomical context of USP39

  • These 2 M. leprae antigens, 36K and 65K, thus seem to contain major T cell epitopes [12].
  • In the cell body preparation, the intermediate filament antibody labeled, in order of their staining intensity, a 65K, 60K, 74K, and 180K protein [13].
  • Immunoblot analysis of human sera from individuals seropositive for HCMV showed that the recombinant pp65 products were as antigenic as the native 65K phosphoprotein produced in HCMV-infected human embryonic fibroblasts [14].
  • Antibody Lan3-8 reacts with neurons in the nerve cord and gut but with epithelial cells in the penis; it binds to a 65K molecule in all three tissues [15].
  • Both gH and gL were transcribed and translated in vitro to give products of apparent M(r) of 65K and 28K in SDS-PAGE, and these could be processed by addition of microsomes to 110K and 40K, respectively [16].

Associations of USP39 with chemical compounds


Analytical, diagnostic and therapeutic context of USP39

  • The 55K and 65K inhibin A forms were purified and found to be fully biologically active in a rat pituitary cell bioassay [22].
  • Finally, the partially purified 65K antigen is an effective absorbant of EBNA antibody as measured in an anticomplement immunofluorescence assay [3].
  • In SDS-PAGE, the purified Co-eIF-2C preparation and an eIF-3 preparation (purified in Dr. A. Wahba's laboratory) separated into seven similar major polypeptides (Mr 110K, 65K, 63K, 53K, 50K, 43K, and 40K) [23].
  • The M. leprae-specific epitopes on the 36K and 65K antigen may help in the development of a specific serodiagnostic and skin test [12].
  • Immunoprecipitation with extracts from infected cells revealed that the antibody recognized four glycosylated proteins (gps) with Mrs of 106K, 102K, 65K and 63K under reducing conditions [24].


  1. Inhibition of DNA-dependent transcription by the leader RNA of vesicular stomatitis virus: role of specific nucleotide sequences and cell protein binding. Grinnell, B.W., Wagner, R.R. Mol. Cell. Biol. (1985) [Pubmed]
  2. Primary structure and transcription of the genes coding for the two virion phosphoproteins pp65 and pp71 of human cytomegalovirus. Rüger, B., Klages, S., Walla, B., Albrecht, J., Fleckenstein, B., Tomlinson, P., Barrell, B. J. Virol. (1987) [Pubmed]
  3. Identification of an Epstein-Barr virus nuclear antigen by fluoroimmunoelectrophoresis and radioimmunoelectrophoresis. Strnad, B.C., Schuster, T.C., Hopkins, R.F., Neubauer, R.H., Rabin, H. J. Virol. (1981) [Pubmed]
  4. In vitro synthesis of adenovirus type 5 T antigens. I. Translation of early region 1-specific rna from lytically infected cells. Lupker, J.H., Davis, A., Jochemsen, H., van der Eb, A.J. J. Virol. (1981) [Pubmed]
  5. Human gamma delta+ T cells respond to mycobacterial heat-shock protein. Haregewoin, A., Soman, G., Hom, R.C., Finberg, R.W. Nature (1989) [Pubmed]
  6. Primary structures of beta- and delta-subunit precursors of Torpedo californica acetylcholine receptor deduced from cDNA sequences. Noda, M., Takahashi, H., Tanabe, T., Toyosato, M., Kikyotani, S., Hirose, T., Asai, M., Takashima, H., Inayama, S., Miyata, T., Numa, S. Nature (1983) [Pubmed]
  7. The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11-59K protein. Benecke, H., Lührmann, R., Will, C.L. EMBO J. (2005) [Pubmed]
  8. A different function for a member of an ancient and highly conserved cytochrome P450 family: From essential sterols to plant defense. Qi, X., Bakht, S., Qin, B., Leggett, M., Hemmings, A., Mellon, F., Eagles, J., Werck-Reichhart, D., Schaller, H., Lesot, A., Melton, R., Osbourn, A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  9. Human U4/U6.U5 and U4atac/U6atac.U5 tri-snRNPs exhibit similar protein compositions. Schneider, C., Will, C.L., Makarova, O.V., Makarov, E.M., Lührmann, R. Mol. Cell. Biol. (2002) [Pubmed]
  10. Characterization of IgG Fc receptors induced by human cytomegalovirus. Xu-Bin, n.u.l.l., Murayama, T., Ishida, K., Furukawa, T. J. Gen. Virol. (1989) [Pubmed]
  11. Varicella-zoster viral glycoproteins analyzed with monoclonal antibodies. Forghani, B., Dupuis, K.W., Schmidt, N.J. J. Virol. (1984) [Pubmed]
  12. T cell epitopes on the 36K and 65K Mycobacterium leprae antigens defined by human T cell clones. Van Schooten, W.C., Ottenhoff, T.H., Klatser, P.R., Thole, J., De Vries, R.R., Kolk, A.H. Eur. J. Immunol. (1988) [Pubmed]
  13. Calcium-activated proteolysis of neurofilament proteins in the squid giant neuron. Gallant, P.E., Pant, H.C., Pruss, R.M., Gainer, H. J. Neurochem. (1986) [Pubmed]
  14. Expression of the human cytomegalovirus 65K tegument phosphoprotein in insect cells by baculovirus vectors. La Fauci, G., Sapienza, V.J., Chen, C.J., Wisniewski, H.M., Kim, K.S. J. Gen. Virol. (1994) [Pubmed]
  15. Cross-reactivities of monoclonal antibodies between select leech neuronal and epithelial tissues. Hogg, N., Flaster, M., Zipser, B. J. Neurosci. Res. (1983) [Pubmed]
  16. Identification and expression of the human herpesvirus 6 glycoprotein H and interaction with an accessory 40K glycoprotein. Liu, D.X., Gompels, U.A., Nicholas, J., Lelliott, C. J. Gen. Virol. (1993) [Pubmed]
  17. Purification and characterization of rabbit ocular mucin. Tseng, S.C., Huang, A.J., Sutter, D. Invest. Ophthalmol. Vis. Sci. (1987) [Pubmed]
  18. Immunochemical characterization of human TL-like (T48) and Ly 1-like (T72) glycoproteins using two-dimensional polyacrylamide gel electrophoresis. Ishii, Y., Fujimoto, J., Kon, S., Ogasawara, M., Koshiba, H., Matsuura, A., Kikuchi, K. Clin. Exp. Immunol. (1981) [Pubmed]
  19. ESR/ENDOR study of guanine.HCl.2H2O X-irradiated at 20K. Nelson, W.H., Hole, E.O., Sagstuen, E., Close, D.M. Int. J. Radiat. Biol. (1988) [Pubmed]
  20. Dynamics of ultrathin films in the glassy state. Xavier, J.H., Li, C., Rafailovich, M.H., Sokolov, J. Langmuir : the ACS journal of surfaces and colloids. (2005) [Pubmed]
  21. Development of molecular probes for simian herpesvirus detection. Hilliard, J.K., Kalter, S.S. Dev. Biol. Stand. (1985) [Pubmed]
  22. Characterization and determination of the biological activities of noncleavable high molecular weight forms of inhibin A and activin A. Mason, A.J., Farnworth, P.G., Sullivan, J. Mol. Endocrinol. (1996) [Pubmed]
  23. Natural mRNA is required for directing Met-tRNA(f) binding to 40S ribosomal subunits in animal cells: involvement of Co-eIF-2A in natural mRNA-directed initiation complex formation. Roy, A.L., Chakrabarti, D., Datta, B., Hileman, R.E., Gupta, N.K. Biochemistry (1988) [Pubmed]
  24. Analysis of human herpesvirus 6 glycoproteins recognized by monoclonal antibody OHV1. Okuno, T., Shao, H., Asada, H., Shiraki, K., Takahashi, M., Yamanishi, K. J. Gen. Virol. (1992) [Pubmed]
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