The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

FERMT1  -  fermitin family member 1

Homo sapiens

Synonyms: C20orf42, DTGCU2, FLJ20116, Fermitin family homolog 1, KIND1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of C20orf42

  • Transcriptional analysis shows that only URP1 is significantly differentially regulated, being over-expressed in 70% of the colon carcinomas and 60% of the lung carcinomas tested [1].
  • Recurrent mutations in kindlin-1, a novel keratinocyte focal contact protein, in the autosomal recessive skin fragility and photosensitivity disorder, Kindler syndrome [2].
  • SETTING: The pediatric ICU at Kind Edward VIII Hospital, Durban, South Africa. PATIENTS: HIV-positive cases were classified as "acquired immunodeficiency syndrome," "symptomatic HIV," and "HIV-unrelated diseases." Controls were matched for age, race, gender, severity of disease, and admitting diagnosis [3].
  • The heat-stable (70degrees C) acid phosphatase test performed by the method of Kind and King is a simple method for differentiating Mycobacterium kansasii, M. marinum, M. gastri, M. nonchromogenicum, and M. triviale from other slowly growing mycobacteria, and M. fortuitum from other rapidly growing acid-fast bacilli [4].
  • In kindlin-1-deficient skin, basal keratinocytes show multiple abnormalities: cell polarity is lost, proliferation is strongly reduced, and several cells undergo apoptosis [5].

Psychiatry related information on C20orf42

  • MEASUREMENTS AND MAIN RESULTS: Kind and amount of sedatives and analgesics, duration of administration, and occurrence of withdrawal symptoms [6].
  • The projectives reviewed include The Rorschach, The Hand Test, The Thematic Apperception Test (TAT), the Kinetic Family Drawings, Human Figure Drawings, Draw Your Favorite Kind of Day, The Rosebush: A Visualization Strategy, and The House-Tree-Person [7].

High impact information on C20orf42

  • Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome [8].
  • Kindlerin might be involved in the bidirectional signaling between integrin molecules in the membrane and the cytoskeleton, and could be involved in cell adhesion processes via integrin signaling [9].
  • We were unable to identify a mutation in kindlerin in a fifth consanguineous family from Algeria with a similar phenotype and in which the patient was homozygous for the markers in the 20p12.3 interval [9].
  • We report the localization to chromosome 20p12.3 by homozygosity mapping and the identification of a new gene, which we propose to name kindlerin [9].
  • The kindlerin protein contains several domains which are shared by a diverse group of peripheral membrane proteins that function as membrane-cytoskeleton linkers: two regions homologous to band 4.1 domain of which one includes a FERM domain with a NPKY sequence motif, and a third region with a PH or pleckstrin homology domain [9].

Biological context of C20orf42


Anatomical context of C20orf42


Associations of C20orf42 with chemical compounds

  • SNP analysis of URP1 reveals that it is highly polymorphic, containing seven sites, four of which are in the coding region and one position that results in the interchangeable substitution of glutamic acid and lysine [1].
  • Ribena Tooth Kind [15].
  • The theme of Pulling Together included the subthemes of Perpetual Vigilance and Returning to Normalcy, and the third theme of Moving Beyond included the subtheme of An Optimal Unfolding of a New Kind of Consciousness [16].
  • This is the contention of Daniel Callahan, who, in his new book, What Kind of Life: The Limits of Medical Progress, calls for a revolution of sorts-a change in the nation's psychological and political foundations [17].
  • The results showed that Kind had a slight color change delta E* = -1.72, Trim demonstrated the most color change delta E* = -13.84, while the remaining resins demonstrated a noticeable change in color due to in vitro aging [18].

Physical interactions of C20orf42

  • The critical residues in the talin FERM domain that mediate integrin binding show a high degree of conservation in kindlerin [12].

Regulatory relationships of C20orf42


Other interactions of C20orf42


Analytical, diagnostic and therapeutic context of C20orf42

  • Northern blot analysis of URP1 indicates that normal expression is restricted to neuromuscular tissues [1].
  • TGF-beta stimulation of HMEC resulted in a marked induction of kindlerin RNA, and Western blotting demonstrated a corresponding increase in protein abundance [12].
  • Dr. Bass felt that his "Right Kind" method of oral hygiene was not well received by the dental profession [20].
  • The recent finding of KIND1 mutations in Kindler syndrome facilitates early diagnosis, prophylactic measures and more precise definition of the phenotype [21].
  • Report on the international workshop of the Kind Philipp Foundation on late effects after bone marrow transplantation in childhood malignancies [22].


  1. URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas. Weinstein, E.J., Bourner, M., Head, R., Zakeri, H., Bauer, C., Mazzarella, R. Biochim. Biophys. Acta (2003) [Pubmed]
  2. Recurrent mutations in kindlin-1, a novel keratinocyte focal contact protein, in the autosomal recessive skin fragility and photosensitivity disorder, Kindler syndrome. Ashton, G.H., McLean, W.H., South, A.P., Oyama, N., Smith, F.J., Al-Suwaid, R., Al-Ismaily, A., Atherton, D.J., Harwood, C.A., Leigh, I.M., Moss, C., Didona, B., Zambruno, G., Patrizi, A., Eady, R.A., McGrath, J.A. J. Invest. Dermatol. (2004) [Pubmed]
  3. Prospective, controlled study of the outcome of human immunodeficiency virus-1 antibody-positive children admitted to an intensive care unit. Jeena, P.M., Coovadia, H.M., Bhagwanjee, S. Crit. Care Med. (1996) [Pubmed]
  4. A new heat-stable acid phosphatase test for mycobacteria. Saito, H., Yamaoka, K., Kiyotani, K., Masai, H. Am. Rev. Respir. Dis. (1976) [Pubmed]
  5. Kindlin-1 is a phosphoprotein involved in regulation of polarity, proliferation, and motility of epidermal keratinocytes. Herz, C., Aumailley, M., Schulte, C., Schlötzer-Schrehardt, U., Bruckner-Tuderman, L., Has, C. J. Biol. Chem. (2006) [Pubmed]
  6. Occurrence of withdrawal in critically ill sedated children. Fonsmark, L., Rasmussen, Y.H., Carl, P. Crit. Care Med. (1999) [Pubmed]
  7. Meta-analysis of studies assessing the efficacy of projective techniques in discriminating child sexual abuse. West, M.M. Child abuse & neglect. (1998) [Pubmed]
  8. Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome. Siegel, D.H., Ashton, G.H., Penagos, H.G., Lee, J.V., Feiler, H.S., Wilhelmsen, K.C., South, A.P., Smith, F.J., Prescott, A.R., Wessagowit, V., Oyama, N., Akiyama, M., Al Aboud, D., Al Aboud, K., Al Githami, A., Al Hawsawi, K., Al Ismaily, A., Al-Suwaid, R., Atherton, D.J., Caputo, R., Fine, J.D., Frieden, I.J., Fuchs, E., Haber, R.M., Harada, T., Kitajima, Y., Mallory, S.B., Ogawa, H., Sahin, S., Shimizu, H., Suga, Y., Tadini, G., Tsuchiya, K., Wiebe, C.B., Wojnarowska, F., Zaghloul, A.B., Hamada, T., Mallipeddi, R., Eady, R.A., McLean, W.H., McGrath, J.A., Epstein, E.H. Am. J. Hum. Genet. (2003) [Pubmed]
  9. Identification of mutations in a new gene encoding a FERM family protein with a pleckstrin homology domain in Kindler syndrome. Jobard, F., Bouadjar, B., Caux, F., Hadj-Rabia, S., Has, C., Matsuda, F., Weissenbach, J., Lathrop, M., Prud'homme, J.F., Fischer, J. Hum. Mol. Genet. (2003) [Pubmed]
  10. Molecular basis of Kindler syndrome in Italy: novel and recurrent Alu/Alu recombination, splice site, nonsense, and frameshift mutations in the KIND1 gene. Has, C., Wessagowit, V., Pascucci, M., Baer, C., Didona, B., Wilhelm, C., Pedicelli, C., Locatelli, A., Kohlhase, J., Ashton, G.H., Tadini, G., Zambruno, G., Bruckner-Tuderman, L., McGrath, J.A., Castiglia, D. J. Invest. Dermatol. (2006) [Pubmed]
  11. Kindler surprise: mutations in a novel actin-associated protein cause Kindler syndrome. White, S.J., McLean, W.H. J. Dermatol. Sci. (2005) [Pubmed]
  12. The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. Kloeker, S., Major, M.B., Calderwood, D.A., Ginsberg, M.H., Jones, D.A., Beckerle, M.C. J. Biol. Chem. (2004) [Pubmed]
  13. The Kindlins: Subcellular localization and expression during murine development. Ussar, S., Wang, H.V., Linder, S., Fässler, R., Moser, M. Exp. Cell Res. (2006) [Pubmed]
  14. Novel KIND1 Gene Mutation in Kindler Syndrome With Severe Gastrointestinal Tract Involvement. Sadler, E., Klausegger, A., Muss, W., Deinsberger, U., Pohla-Gubo, G., Laimer, M., Lanschuetzer, C., Bauer, J.W., Hintner, H. Archives of dermatology (2006) [Pubmed]
  15. Ribena Tooth Kind. Grace, M. British dental journal. (1998) [Pubmed]
  16. One breath at a time: living with cystic fibrosis. Rinaldi Carpenter, D., Narsavage, G.L. Journal of pediatric nursing. (2004) [Pubmed]
  17. A call to revolution. Grimaldi, P.L. Health progress (Saint Louis, Mo.) (1990) [Pubmed]
  18. In vitro color stability of provisional restorations. Yaman, P., Razzoog, M., Brandau, H.E. American journal of dentistry. (1989) [Pubmed]
  19. Kindler syndrome. Ashton, G.H. Clin. Exp. Dermatol. (2004) [Pubmed]
  20. The Bass technique: Charles Cassidy Bass' legacy. Crews, K., O'Hara, J., Gordy, F., Penton, N. Mississippi Dental Association journal. (1995) [Pubmed]
  21. Retrospective diagnosis of Kindler syndrome in a 37-year-old man. Thomson, M.A., Ashton, G.H., McGrath, J.A., Eady, R.A., Moss, C. Clin. Exp. Dermatol. (2006) [Pubmed]
  22. Report on the international workshop of the Kind Philipp Foundation on late effects after bone marrow transplantation in childhood malignancies. Dopfer, R., Niethammer, D. Pediatric hematology and oncology. (1993) [Pubmed]
WikiGenes - Universities