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Gene Review

Ggm1  -  ganglioside expression 1

Mus musculus

Synonyms: Ggm-1
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Disease relevance of Ggm1


High impact information on Ggm1


Chemical compound and disease context of Ggm1


Biological context of Ggm1


Anatomical context of Ggm1


Associations of Ggm1 with chemical compounds

  • 2. Because of the importance of gangliosides in cancer pathogenesis, we investigated the effects of n-butyrate on ganglioside expression of colonic (human and murine) and non-colonic cancer cells [4].

Other interactions of Ggm1


Analytical, diagnostic and therapeutic context of Ggm1

  • Based upon the mobility on high-performance thin-layer chromatography, mouse ovary consisted of at least five different ganglioside components, mainly gangliosides GM3, GM1, GD1a and GT1b, and diabetic ovary exhibited a significant reduction in ganglioside expression with apparent changes in the major gangliosides [22].


  1. Analysis of melanoma cells stably transfected with beta 1,4GalNAc transferase (GM2/GD2 synthase) cDNA: relative glycosyltransferase levels play a dominant role in determining ganglioside expression. Ruan, S., Raj, B.K., Furukawa, K., Lloyd, K.O. Arch. Biochem. Biophys. (1995) [Pubmed]
  2. Occurrence of lacto series gangliosides 3'-isoLM1 and 3',6'-isoLD1 in human gliomas in vitro and in vivo. Wikstrand, C.J., He, X.M., Fuller, G.N., Bigner, S.H., Fredman, P., Svennerholm, L., Bigner, D.D. J. Neuropathol. Exp. Neurol. (1991) [Pubmed]
  3. Glycosphingolipid expression on murine L1-fibrosarcoma cells: analysis of clonal in vivo and in vitro selected sublines with different lung colonisation potential. Hanisch, F.G., Sölter, J., Jansen, V., Lochner, A., Peter-Katalinic, J., Uhlenbruck, G. Br. J. Cancer (1990) [Pubmed]
  4. n-Butyrate mediation of ganglioside expression of human and murine cancer cells demonstrates relative cell specificity. Berenson, C.S., Patterson, M.A., Miqdadi, J.A., Lance, P. Clin. Sci. (1995) [Pubmed]
  5. Lactotetraose series ganglioside 3',6'-isoLD1 in tumors of central nervous and other systems in vitro and in vivo. Wikstrand, C.J., Longee, D.C., McLendon, R.E., Fuller, G.N., Friedman, H.S., Fredman, P., Svennerholm, L., Bigner, D.D. Cancer Res. (1993) [Pubmed]
  6. Ganglioside expression in macrophages from endotoxin responder and nonresponder mice. Yohe, H.C., Ryan, J.L. J. Immunol. (1986) [Pubmed]
  7. Differences in splenic B-lymphocyte ganglioside expression and accessibility in normal and endotoxin-hyporesponsive mice. Berenson, C.S., Rasp, R.H., Gau, J.T., Ryan, J.L., Yohe, H.C. J. Leukoc. Biol. (2001) [Pubmed]
  8. Heterogeneity in the expression pattern of two ganglioside synthase genes during mouse brain development. Yamamoto, A., Haraguchi, M., Yamashiro, S., Fukumoto, S., Furukawa, K., Takamiya, K., Atsuta, M., Shiku, H., Furukawa, K. J. Neurochem. (1996) [Pubmed]
  9. Human melanoma cell lines deficient in GD3 ganglioside expression exhibit altered growth and tumorigenic characteristics. Nakano, J., Raj, B.K., Asagami, C., Lloyd, K.O. J. Invest. Dermatol. (1996) [Pubmed]
  10. Cytotoxicity of L-cycloserine against human neuroblastoma and medulloblastoma cells is associated with the suppression of ganglioside expression. Cinatl, J., Cinatl, J., Kotchetkov, R., Pouckova, P., Vogel, J.U., Rabenau, H., Michaelis, M., Kornhuber, B. Anticancer Res. (1999) [Pubmed]
  11. The locus controlling liver GM1(NeuGc) expression is mapped 1 cM centromeric to H-2K. Sakaizumi, M., Hashimoto, Y., Suzuki, A., Yamakawa, T., Kiuchi, Y., Moriwaki, K. Immunogenetics (1988) [Pubmed]
  12. Pancreatic islet ganglioside expression in nonobese diabetic mice: comparison with C57BL/10 mice and changes after autoimmune beta-cell destruction. Dotta, F., Peterson, L.B., Previti, M., Metzger, J., Tiberti, C., Anastasi, E., Zoppitelli, P., Wicker, L.S., Di Mario, U. Endocrinology (1992) [Pubmed]
  13. Biochemical and genetic basis for the ETS (enterotoxin sensitivity) phenotype in mice. Richardson, S.H., Sexton, T., Rader, J., Kajs, C. Clin. Infect. Dis. (1993) [Pubmed]
  14. Molecular cloning and functional expression of a fifth-type alpha 2,3-sialyltransferase (mST3Gal V: GM3 synthase). Kono, M., Takashima, S., Liu, H., Inoue, M., Kojima, N., Lee, Y.C., Hamamoto, T., Tsuji, S. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  15. Genetic polymorphism of ganglioside expression in mouse organs. Nakamura, K., Hashimoto, Y., Yamakawa, T., Suzuki, A. J. Biochem. (1988) [Pubmed]
  16. Genetic regulation of GM4(NeuAc) expression in mouse erythrocytes. Nakamura, K., Hashimoto, Y., Moriwaki, K., Yamakawa, T., Suzuki, A. J. Biochem. (1990) [Pubmed]
  17. Expression of GD3 disialoganglioside antigen on peripheral T-lymphocytes in patients with disseminated malignant melanoma. Welte, B., Handgretinger, R., Rassner, G., Fierlbeck, G. Exp. Dermatol. (1997) [Pubmed]
  18. Role of cell surface GM3 ganglioside and sialic acid in the antitumor activity of a GM3-based vaccine in the murine B16 melanoma model. Gabri, M.R., Ripoll, G.V., Alonso, D.F., Gómez, D.E. J. Cancer Res. Clin. Oncol. (2002) [Pubmed]
  19. Changes of sphingolipid species in the phenotype conversion from myofibroblasts to lipocytes in hepatic stellate cells. Andrade, C.M., Trindade, V.M., Cardoso, C.C., Ziulkoski, A.L., Trugo, L.C., Guaragna, R.M., Borojevic, R., Guma, F.C. J. Cell. Biochem. (2003) [Pubmed]
  20. Factors mediating lipopolysaccharide-induced ganglioside expression in murine peritoneal macrophages. Berenson, C.S., Yohe, H.C., Ryan, J.L. J. Leukoc. Biol. (1989) [Pubmed]
  21. Ganglioside expression in tissues of mice lacking beta2-microglobulin. Markotić, A., Marusić, A., Tomac, J., Müthing, J. Clin. Exp. Immunol. (2002) [Pubmed]
  22. Differential expression of gangliosides in the ovary and uterus of streptozotocin-induced and db/db diabetic mice. Kim, S.M., Kwak, D.H., Kim, S.M., Jung, J.U., Lee, D.H., Lee, S., Jung, K.Y., Do, S.I., Choo, Y.K. Arch. Pharm. Res. (2006) [Pubmed]
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