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Gene Review

Cyp2a  -  cytochrome P450, family 2, subfamily a

Mus musculus

Synonyms: phenobarbital inducible
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Disease relevance of Cyp2a


High impact information on Cyp2a


Biological context of Cyp2a


Anatomical context of Cyp2a


Associations of Cyp2a with chemical compounds


Other interactions of Cyp2a

  • An analysis of two sets of multilocus crosses revealed that the Akt2 gene is closely linked to the Cyp2a locus in proximal MMU7 [17].
  • Both the constitutive and phenobarbital-inducible expression of Cyp2b-9 and Cyp2b-10 mRNA decreased rapidly after transferring the hepatocytes to monolayer culture [18].
  • A cDNA (pP-450b-5) to a major phenobarbital-inducible cytochrome P-450 mRNA species in the rat detected 6 polymorphic DNA fragments when hybridized to DNA from C57BL/6J and DBA/2J mice restricted with endonucleases EcoRI, BamHI, and PvuII [9].
  • Nucleotide homology between a member of either gene subfamily is about 30%, and protein homology is about 15%, suggesting that the Ah locus-associated P-450 gene subfamily diverged from the phenobarbital inducible P-450 subfamily more than 200 million years ago [19].

Analytical, diagnostic and therapeutic context of Cyp2a


  1. Overexpression of a cytochrome P-450 of the 2a family (Cyp2a-5) in chemically induced hepatomas from female mice. Jounaïdi, Y., Bonfils, C., Périn, F., Negishi, M., Lange, R. Eur. J. Biochem. (1994) [Pubmed]
  2. Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. Schwartz, R.E., Reyes, M., Koodie, L., Jiang, Y., Blackstad, M., Lund, T., Lenvik, T., Johnson, S., Hu, W.S., Verfaillie, C.M. J. Clin. Invest. (2002) [Pubmed]
  3. Isolation and sequence of a human cytochrome P-450 cDNA clone. Phillips, I.R., Shephard, E.A., Ashworth, A., Rabin, B.R. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  4. Regulation of cytochrome P450 gene transcription by phenobarbital. Kemper, B. Prog. Nucleic Acid Res. Mol. Biol. (1998) [Pubmed]
  5. Phenobarbital causes apoptosis in conditionally immortalized mouse hepatocytes depending on deregulated c-myc expression: characterization of an unexpected effect. Osanai, M., Ogawa, K., Lee, G.H. Cancer Res. (1997) [Pubmed]
  6. Cytochrome P-450 gene expression in the functional units of the fetal liver. Chianale, J., Dvorak, C., Farmer, D.L., Michaels, L., Gumucio, J.J. Hepatology (1988) [Pubmed]
  7. Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to Cyp2b and Coh on mouse chromosome 7. Miles, J.S., Moss, J.E., Meehan, R.R., Wolf, C.R. Genomics (1990) [Pubmed]
  8. Gender-specific induction of cytochrome P450s in nonylphenol-treated FVB/NJ mice. Hernandez, J.P., Chapman, L.M., Kretschmer, X.C., Baldwin, W.S. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  9. Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice. Simmons, D.L., Kasper, C.B. J. Biol. Chem. (1983) [Pubmed]
  10. P450 isoforms in a murine macrophage cell line, RAW264.7, and changes in the levels of P450 isoforms by treatment of cells with lipopolysaccharide and interferon-gamma. Nakamura, M., Imaoka, S., Amano, F., Funae, Y. Biochim. Biophys. Acta (1998) [Pubmed]
  11. Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA. Noshiro, M., Lakso, M., Kawajiri, K., Negishi, M. Biochemistry (1988) [Pubmed]
  12. Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes. Honkakoski, P., Moore, R., Gynther, J., Negishi, M. J. Biol. Chem. (1996) [Pubmed]
  13. Localization of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 in mouse lung with monoclonal antibodies. Forkert, P.G., Vessey, M.L., Elce, J.S., Park, S.S., Gelboin, H.V., Cole, S.P. Res. Commun. Chem. Pathol. Pharmacol. (1986) [Pubmed]
  14. Activities of cytochrome p450 enzymes in liver and kidney microsomes from systemic carnitine deficiency mice with a gene mutation of carnitine/organic cation transporter. Yamazaki, H., Iketaki, H., Shibata, A., Nakajima, M., Yokoi, T. Drug Metab. Pharmacokinet. (2002) [Pubmed]
  15. Mouse liver P450Coh: genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes. Lang, M.A., Juvonen, R., Järvinen, P., Honkakoski, P., Raunio, H. Arch. Biochem. Biophys. (1989) [Pubmed]
  16. Kupffer cells and reactive oxygen species partially mediate lipopolysaccharide-induced downregulation of nuclear receptor pregnane x receptor and its target gene CYP3a in mouse liver. Xu, D.X., Wei, W., Sun, M.F., Wu, C.Y., Wang, J.P., Wei, L.Z., Zhou, C.F. Free Radic. Biol. Med. (2004) [Pubmed]
  17. Chromosome mapping of the mouse Akt2 gene and Akt2 pseudogene. Altomare, D.A., Kozak, C.A., Sonoda, G., Testa, J.R. Cytogenet. Cell Genet. (1996) [Pubmed]
  18. Maintenance of phenobarbital-inducible Cyp2b gene expression in C57BL/6 mouse hepatocytes in primary culture as spheroids. Nemoto, N., Sakurai, J., Funae, Y. Arch. Biochem. Biophys. (1995) [Pubmed]
  19. The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences. Kimura, S., Gonzalez, F.J., Nebert, D.W. J. Biol. Chem. (1984) [Pubmed]
  20. Regulation of phenobarbital-inducible cytochrome P-450s in rat and mouse liver following dexamethasone administration and hypophysectomy. Meehan, R.R., Forrester, L.M., Stevenson, K., Hastie, N.D., Buchmann, A., Kunz, H.W., Wolf, C.R. Biochem. J. (1988) [Pubmed]
  21. High activity of cytochrome P-450-linked aminopyrine N-demethylase in mouse brain microsomes, and associated sex-related difference. Ravindranath, V., Ananda Theertha Varada, H.K. Biochem. J. (1989) [Pubmed]
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