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Gene Review

Alox12  -  arachidonate 12-lipoxygenase

Mus musculus

Synonyms: 12S-LOX, 12S-lipoxygenase, 9930022G08Rik, Alox12p, Arachidonate 12-lipoxygenase, 12S-type, ...
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Disease relevance of Alox12

  • We observed that platelets obtained from mice in which the P-12LO gene has been disrupted by gene targeting (P-12LO-/-) exhibit a selective hypersensitivity to ADP, manifested as a marked increase in slope and percent aggregation in ex vivo assays and increased mortality in an ADP-induced mouse model of thromboembolism [1].
  • Platelet 12-lipoxygenase (P-12-LOX) is overexpressed in different types of cancers, including prostate cancer, and the level of expression is correlated with the grade of this cancer [2].
  • 12-lipoxygenase (12-lipoxygenase) (12-LOX) was recruited to glycosphingolipid-enriched microdomains (GEM) in a GM3-dependent manner during oxidative glutamate toxicity [3].

High impact information on Alox12


Chemical compound and disease context of Alox12


Biological context of Alox12


Anatomical context of Alox12

  • In contrast, at the 12-LOX protein level we observed a Ca(2+)-dependent loss in the cytosol and a concomitant increase in the membrane fraction [6].
  • Comparison with platelet and leukocyte 12-LOX indicates that 3LL 12-LOX is identical with the platelet-type enzyme at least within the sequenced region [6].
  • 12-LOX activity was monitored via the production of 12-hyroxyeicosatetraenoic acid from 3LL cells and their subcellular fractions using reverse-phase high performance liquid chromatography [6].
  • Additionally, the curcuminoids inhibiting P-12-LOX were tested for their ability to reduce sprout formation of endothelial cells (in vitro model of angiogenesis) [2].

Associations of Alox12 with chemical compounds

  • Docking of the known inhibitors curcumin and NDGA to P-12-LOX was used to optimize the docking protocol for the system in study [2].

Other interactions of Alox12


Analytical, diagnostic and therapeutic context of Alox12


  1. Increased platelet sensitivity to ADP in mice lacking platelet-type 12-lipoxygenase. Johnson, E.N., Brass, L.F., Funk, C.D. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells. Jankun, J., Aleem, A.M., Malgorzewicz, S., Szkudlarek, M., Zavodszky, M.I., Dewitt, D.L., Feig, M., Selman, S.H., Skrzypczak-Jankun, E. Mol. Cancer Ther. (2006) [Pubmed]
  3. Ganglioside GM3 is involved in neuronal cell death. Sohn, H., Kim, Y.S., Kim, H.T., Kim, C.H., Cho, E.W., Kang, H.Y., Kim, N.S., Kim, C.H., Ryu, S.E., Lee, J.H., Ko, J.H. FASEB J. (2006) [Pubmed]
  4. Functional expression and cellular localization of a mouse epidermal lipoxygenase. Funk, C.D., Keeney, D.S., Oliw, E.H., Boeglin, W.E., Brash, A.R. J. Biol. Chem. (1996) [Pubmed]
  5. Expression of arachidonate 12-lipoxygenase in rat tissues: a possible role in glucagon secretion. Kawajiri, H., Zhuang, D., Qiao, N., Yoshimoto, T., Yamamoto, M., Iseki, S., Hamaguchi, K. J. Histochem. Cytochem. (2000) [Pubmed]
  6. 12-Lipoxygenase in Lewis lung carcinoma cells: molecular identity, intracellular distribution of activity and protein, and Ca(2+)-dependent translocation from cytosol to membranes. Hagmann, W., Gao, X., Zacharek, A., Wojciechowski, L.A., Honn, K.V. Prostaglandins (1995) [Pubmed]
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