Gene Review:
Alox15 - arachidonate 15-lipoxygenase
Mus musculus
Synonyms:
12-LO, 12-LOX, 12/15-LO, 12/15-lipoxygenase, 15-LOX, ...
- Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice. Cyrus, T., Witztum, J.L., Rader, D.J., Tangirala, R., Fazio, S., Linton, M.F., Funk, C.D. J. Clin. Invest. (1999)
- Mice deficient for 5-lipoxygenase, but not leukocyte-type 12-lipoxygenase, display altered immune responses during infection with Schistosoma mansoni. Secor, W.E., Powell, M.R., Morgan, J., Wynn, T.A., Funk, C.D. Prostaglandins Other Lipid Mediat. (1998)
- Characterization of the murine epidermal 12/15-lipoxygenase. McDonnell, M., Davis, W., Li, H., Funk, C.D. Prostaglandins Other Lipid Mediat. (2001)
- Ganglioside GM3 is involved in neuronal cell death. Sohn, H., Kim, Y.S., Kim, H.T., Kim, C.H., Cho, E.W., Kang, H.Y., Kim, N.S., Kim, C.H., Ryu, S.E., Lee, J.H., Ko, J.H. FASEB J. (2006)
- Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells. Jankun, J., Aleem, A.M., Malgorzewicz, S., Szkudlarek, M., Zavodszky, M.I., Dewitt, D.L., Feig, M., Selman, S.H., Skrzypczak-Jankun, E. Mol. Cancer Ther. (2006)
- Augmented responses to morphine and cocaine in mice with a 12-lipoxygenase gene disruption. Walters, C.L., Wang, B.C., Godfrey, M., Sun, D., Funk, C.D., Blendy, J.A. Psychopharmacology (Berl.) (2003)
- Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice. Bleich, D., Chen, S., Zipser, B., Sun, D., Funk, C.D., Nadler, J.L. J. Clin. Invest. (1999)
- A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense. Gronert, K., Maheshwari, N., Khan, N., Hassan, I.R., Dunn, M., Laniado Schwartzman, M. J. Biol. Chem. (2005)
- Regulation of bone mass in mice by the lipoxygenase gene Alox15. Klein, R.F., Allard, J., Avnur, Z., Nikolcheva, T., Rotstein, D., Carlos, A.S., Shea, M., Waters, R.V., Belknap, J.K., Peltz, G., Orwoll, E.S. Science (2004)
- Functional expression and cellular localization of a mouse epidermal lipoxygenase. Funk, C.D., Keeney, D.S., Oliw, E.H., Boeglin, W.E., Brash, A.R. J. Biol. Chem. (1996)
- Understanding our drugs and our diseases. Guo, Y., Weller, P., Allard, J., Usuka, J., Masjedizadeh, M., Wu, S.Y., Fitch, B., Clark, D., Clark, J.D., Shafer, S., Wang, J., Liao, G., Peltz, G. Proceedings of the American Thoracic Society. (2006)
- Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein. Sun, D., Funk, C.D. J. Biol. Chem. (1996)
- Novel 10-substituted antipsoriatic anthrones as inhibitors of epidermal 12-lipoxygenase and lipid peroxidation in membranes. Müller, K., Gawlik, I. Biochem. Pharmacol. (1995)
- Wy-48,252 (1,1,1-trifluoro-N-[3-(2-quinolinylmethoxy)phenyl]membrane sulfonamide), an orally active leukotriene antagonist: effects on arachidonic acid metabolism in various inflammatory cells. Chang, J., Borgeat, P., Schleimer, R.P., Musser, J.H., Marshall, L.A., Hand, J.M. Eur. J. Pharmacol. (1988)
- Reactive oxygen species and not lipoxygenase products are required for mouse B-lymphocyte activation and differentiation. Fedyk, E.R., Phipps, R.P. Int. J. Immunopharmacol. (1994)
- Induction of cyclooxygenase-2 gene in pancreatic beta-cells by 12-lipoxygenase pathway product 12-hydroxyeicosatetraenoic acid. Han, X., Chen, S., Sun, Y., Nadler, J.L., Bleich, D. Mol. Endocrinol. (2002)
- 12-lipoxygenase pathway increases aldosterone production, 3',5'-cyclic adenosine monophosphate response element-binding protein phosphorylation, and p38 mitogen-activated protein kinase activation in H295R human adrenocortical cells. Gu, J., Wen, Y., Mison, A., Nadler, J.L. Endocrinology (2003)
- Evidence that increased 12-lipoxygenase expression impairs pancreatic beta cell function and viability. Prasad, K.M., Thimmalapura, P.R., Woode, E.A., Nadler, J.L. Biochem. Biophys. Res. Commun. (2003)
- Gonadotropin-releasing hormone activates the 12-lipoxygenase pathway in the LbetaT2 gonadotrope cell line. Limor, R., Naor, Z., Weisinger, G., Naidich, M., Knoll, E., Sharon, O., Stern, N. Neuroendocrinology (2003)
- Role of 12-lipoxygenase in the stimulation of p38 mitogen-activated protein kinase and collagen alpha5(IV) in experimental diabetic nephropathy and in glucose-stimulated podocytes. Kang, S.W., Natarajan, R., Shahed, A., Nast, C.C., LaPage, J., Mundel, P., Kashtan, C., Adler, S.G. J. Am. Soc. Nephrol. (2003)
- Activation of 12-lipoxygenase in proinflammatory cytokine-mediated beta cell toxicity. Chen, M., Yang, Z.D., Smith, K.M., Carter, J.D., Nadler, J.L. Diabetologia (2005)
- Role of 12-lipoxygenase in volatile anesthetic-induced delayed preconditioning in mice. Tsutsumi, Y.M., Patel, H.H., Huang, D., Roth, D.M. Am. J. Physiol. Heart Circ. Physiol. (2006)