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Chemical Compound Review

12-Hete     (5E,8Z,10Z,14Z)-12- hydroxyicosa-5,8,10,14...

Synonyms: HMDB06111, AC1NSO0E, LS-63794, LMFA03060063, 71030-37-0, ...
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Disease relevance of 12-Hete


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Chemical compound and disease context of 12-Hete


Biological context of 12-Hete


Anatomical context of 12-Hete


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Gene context of 12-Hete


Analytical, diagnostic and therapeutic context of 12-Hete


  1. Platelet-derived 12-hydroxyeicosatetraenoic acid plays an important role in mediating canine coronary thrombosis by regulating platelet glycoprotein IIb/IIIa activation. Katoh, A., Ikeda, H., Murohara, T., Haramaki, N., Ito, H., Imaizumi, T. Circulation (1998) [Pubmed]
  2. Induction of inflammatory mediator release (serotonin and 12-hydroxyeicosatetraenoic acid) from human platelets by Pseudomonas aeruginosa glycolipid. König, B., Bergmann, U., König, W. Infect. Immun. (1992) [Pubmed]
  3. Brain microvessels produce 12-hydroxyeicosatetraenoic acid. Moore, S.A., Figard, P.H., Spector, A.A., Hart, M.N. J. Neurochem. (1989) [Pubmed]
  4. Signal transduction in human platelets and inflammatory mediator release induced by genetically cloned hemolysin-positive and -negative Escherichia coli strains. König, B., Schönfeld, W., Scheffer, J., König, W. Infect. Immun. (1990) [Pubmed]
  5. Inhibition of 12(S)-hydroxyeicosatetraenoic acid [12(S)-HETE] binding to epidermal cells by ultraviolet-B. Kemény, L., Przybilla, B., Gross, E., Arenberger, P., Ruzicka, T. J. Invest. Dermatol. (1991) [Pubmed]
  6. Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice. Bleich, D., Chen, S., Zipser, B., Sun, D., Funk, C.D., Nadler, J.L. J. Clin. Invest. (1999) [Pubmed]
  7. Mesangial cell immune injury. Synthesis, origin, and role of eicosanoids. Lianos, E.A., Bresnahan, B.A., Pan, C. J. Clin. Invest. (1991) [Pubmed]
  8. Studies on the mechanism of omega-hydroxylation of platelet 12-hydroxyeicosatetraenoic acid (12-HETE) by unstimulated neutrophils. Marcus, A.J., Safier, L.B., Ullman, H.L., Islam, N., Broekman, M.J., von Schacky, C. J. Clin. Invest. (1987) [Pubmed]
  9. Increased platelet sensitivity to ADP in mice lacking platelet-type 12-lipoxygenase. Johnson, E.N., Brass, L.F., Funk, C.D. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  10. Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. Grossi, I.M., Fitzgerald, L.A., Umbarger, L.A., Nelson, K.K., Diglio, C.A., Taylor, J.D., Honn, K.V. Cancer Res. (1989) [Pubmed]
  11. Platelet lipoxygenase in spontaneously hypertensive rats. Stern, N., Kisch, E.S., Knoll, E. Hypertension (1996) [Pubmed]
  12. High-affinity binding and lack of growth-promoting activity of 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) in a human epidermal cell line. Gross, E., Ruzicka, T., von Restorff, B., Stolz, W., Klotz, K.N. J. Invest. Dermatol. (1990) [Pubmed]
  13. Effect of lipoxins and other eicosanoids on phagocytosis and intracellular calcium mobilisation in rainbow trout (Oncorhynchus mykiss) leukocytes. Knight, J., Lloyd-Evans, P., Rowley, A.F., Barrow, S.E. J. Leukoc. Biol. (1993) [Pubmed]
  14. 12-Lipoxygenase inhibition induced apoptosis in human gastric cancer cells. Wong, B.C., Wang, W.P., Cho, C.H., Fan, X.M., Lin, M.C., Kung, H.F., Lam, S.K. Carcinogenesis (2001) [Pubmed]
  15. Effect of extracellular magnesium on platelet activation and intracellular calcium mobilization. Hwang, D.L., Yen, C.F., Nadler, J.L. Am. J. Hypertens. (1992) [Pubmed]
  16. 12-Hydroxyeicosatetraenoic acid is metabolized by beta-oxidation in mouse peritoneal macrophages. Identification of products and proposed pathway. Mathur, S.N., Albright, E., Field, F.J. J. Biol. Chem. (1990) [Pubmed]
  17. The mitogenic effect of 15- and 12-hydroxyeicosatetraenoic acid on endothelial cells may be mediated via diacylglycerol kinase inhibition. Setty, B.N., Graeber, J.E., Stuart, M.J. J. Biol. Chem. (1987) [Pubmed]
  18. Arachidonic acid metabolism by erythrocytes. Kobayashi, T., Levine, L. J. Biol. Chem. (1983) [Pubmed]
  19. Induction of cyclooxygenase-2 gene in pancreatic beta-cells by 12-lipoxygenase pathway product 12-hydroxyeicosatetraenoic acid. Han, X., Chen, S., Sun, Y., Nadler, J.L., Bleich, D. Mol. Endocrinol. (2002) [Pubmed]
  20. Effect of leukotrienes, 12-HETE, histamine, bradykinin, and 5-hydroxytryptamine on in vivo rabbit cerebral arteriolar diameter. Kamitani, T., Little, M.H., Ellis, E.F. J. Cereb. Blood Flow Metab. (1985) [Pubmed]
  21. Inhibitory effect of exogenous arachidonic acid on alveolar macrophage 5-lipoxygenase metabolism. Role of ATP depletion. Peters-Golden, M., Shelly, C. J. Immunol. (1988) [Pubmed]
  22. The inhibitory role of 12- and 15-lipoxygenase products on renin release. Antonipillai, I., Nadler, J.L., Robin, E.C., Horton, R. Hypertension (1987) [Pubmed]
  23. Leukotriene B4 and 12-hydroxyeicosatetraenoic acid stimulate epidermal proliferation in vivo in the guinea pig. Chan, C.C., Duhamel, L., Ford-Hutchison, A. J. Invest. Dermatol. (1985) [Pubmed]
  24. The selective cyclooxygenase-2 inhibitor celecoxib modulates the formation of vasoconstrictor eicosanoids and activates PPARgamma. Influence of albumin. López-Parra, M., Clària, J., Titos, E., Planagumà, A., Párrizas, M., Masferrer, J.L., Jiménez, W., Arroyo, V., Rivera, F., Rodés, J. J. Hepatol. (2005) [Pubmed]
  25. Effect of cholesterol enrichment on 12-hydroxyeicosatetraenoic acid metabolism by mouse peritoneal macrophages. Mathur, S.N., Field, F.J. J. Lipid Res. (1987) [Pubmed]
  26. Evidence that 12-lipoxygenase product 12-hydroxyeicosatetraenoic acid activates p21-activated kinase. Wen, Y., Gu, J., Knaus, U.G., Thomas, L., Gonzales, N., Nadler, J.L. Biochem. J. (2000) [Pubmed]
  27. Role of the Pyk2-MAP kinase-cPLA2 signaling pathway in shear-dependent platelet aggregation. Sun, L., Feng, S., Reséndiz, J.C., Lu, X., Durante, W., Kroll, M.H. Annals of biomedical engineering. (2004) [Pubmed]
  28. Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenase. Huber, J., Fürnkranz, A., Bochkov, V.N., Patricia, M.K., Lee, H., Hedrick, C.C., Berliner, J.A., Binder, B.R., Leitinger, N. J. Lipid Res. (2006) [Pubmed]
  29. Eicosanoids as mediators of linoleic acid-stimulated invasion and type IV collagenase production by a metastatic human breast cancer cell line. Liu, X.H., Connolly, J.M., Rose, D.P. Clin. Exp. Metastasis (1996) [Pubmed]
  30. Croconazole: an inhibitor of eicosanoid synthesis in A23187-stimulated human polymorphonuclear leukocytes and human whole blood. Lehmann, B., Wozel, G., Steinmann, D., Barth, J. Skin Pharmacol. (1995) [Pubmed]
  31. Specific action of the lipoxygenase pathway in mediating angiotensin II-induced aldosterone synthesis in isolated adrenal glomerulosa cells. Nadler, J.L., Natarajan, R., Stern, N. J. Clin. Invest. (1987) [Pubmed]
  32. Toxoplasma gondii stimulates the release of 13- and 9-hydroxyoctadecadienoic acids by human platelets. Henderson, W.R., Rashed, M., Yong, E.C., Fritsche, T.R., Chiang, G.K. Biochemistry (1992) [Pubmed]
  33. Lipoxygenase activity in heart cells. Breitbart, E., Sofer, Y., Shainberg, A., Grossman, S. FEBS Lett. (1996) [Pubmed]
  34. Augmented insulinotropic action of arachidonic acid through the lipoxygenase pathway in the obese Zucker rat. Ahrén, B., Magrum, L.J., Havel, P.J., Greene, S.F., Phinney, S.D., Johnson, P.R., Stern, J.S. Obes. Res. (2000) [Pubmed]
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