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Artn  -  artemin

Mus musculus

Synonyms: Artemin, neublastin
 
 
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Disease relevance of Artn

 

High impact information on Artn

  • Artemin (ARTN) is a member of the GDNF family of ligands and signals through the Ret/GFRalpha3 receptor complex [3].
  • GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion [4].
  • Confirming the physiological relevance of the mitogenic action of artemin on cultured neuroblasts, there was a marked reduction in the rate of neuroblast proliferation in the sympathetic ganglia of mice lacking the GFRalpha3 subunit of the artemin receptor [5].
  • During this late period of development, artemin also enhanced the growth of neurites from cultured neurones more effectively than NGF [5].
  • Glial cell line-derived neurotrophic factor (GDNF), neurturin (NTN) and neublastin/artemin (ART) are distant members of the transforming growth factor beta family, and have been shown to elicit neurotrophic effects upon several classes of peripheral and central neurons [6].
 

Biological context of Artn

 

Anatomical context of Artn

  • The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction [9].
  • Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold [7].
  • Artemin, a neuronal survival factor in the glial cell line-derived neurotrophic factor family, binds the glycosylphosphatidylinositol-anchored protein GFRalpha3 and the receptor tyrosine kinase Ret [7].
  • To determine how artemin affects sensory neuron properties, transgenic mice that overexpress artemin in skin keratinocytes (ART-OE mice) were analyzed [7].
  • These results strongly suggest that AR exerts antinociceptive effects on herpes-related pain through changes of the dynorphin levels in the central nervous system of HSV-inoculated mice [2].
 

Associations of Artn with chemical compounds

  • Artemin crystal structure reveals insights into heparan sulfate binding [10].
  • Intraperitoneal administration of AR at a dose of 1.5 mg/kg scarcely affected beta-endorphin and noradrenaline levels in the central nervous system of HSV-inoculated mice [2].
 

Other interactions of Artn

References

  1. Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo. Malin, S.A., Molliver, D.C., Koerber, H.R., Cornuet, P., Frye, R., Albers, K.M., Davis, B.M. J. Neurosci. (2006) [Pubmed]
  2. Attenuating effect of artemin on herpes-related pain responses in mice infected with herpes simplex. Asano, K., Asahina, S., Sakai, M., Matsuda, T., Ou, K., Maeda, Y., Hisamitsu, T. In Vivo (2006) [Pubmed]
  3. Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons. Honma, Y., Araki, T., Gianino, S., Bruce, A., Heuckeroth, R., Johnson, E., Milbrandt, J. Neuron (2002) [Pubmed]
  4. GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion. Nishino, J., Mochida, K., Ohfuji, Y., Shimazaki, T., Meno, C., Ohishi, S., Matsuda, Y., Fujii, H., Saijoh, Y., Hamada, H. Neuron (1999) [Pubmed]
  5. Multiple effects of artemin on sympathetic neurone generation, survival and growth. Andres, R., Forgie, A., Wyatt, S., Chen, Q., de Sauvage, F.J., Davies, A.M. Development (2001) [Pubmed]
  6. Positive and negative interactions of GDNF, NTN and ART in developing sensory neuron subpopulations, and their collaboration with neurotrophins. Baudet, C., Mikaels, A., Westphal, H., Johansen, J., Johansen, T.E., Ernfors, P. Development (2000) [Pubmed]
  7. Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold. Elitt, C.M., McIlwrath, S.L., Lawson, J.J., Malin, S.A., Molliver, D.C., Cornuet, P.K., Koerber, H.R., Davis, B.M., Albers, K.M. J. Neurosci. (2006) [Pubmed]
  8. Neural cells in the esophagus respond to glial cell line-derived neurotrophic factor and neurturin, and are RET-dependent. Yan, H., Bergner, A.J., Enomoto, H., Milbrandt, J., Newgreen, D.F., Young, H.M. Dev. Biol. (2004) [Pubmed]
  9. The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction. Bolon, B., Jing, S., Asuncion, F., Scully, S., Pisegna, M., Van, G.Y., Hu, Z., Yu, Y.B., Min, H., Wild, K., Rosenfeld, R.D., Tarpley, J., Carnahan, J., Duryea, D., Hill, D., Kaufman, S., Yan, X.Q., Juan, T., Christensen, K., McCabe, J., Simonet, W.S. Toxicologic pathology. (2004) [Pubmed]
  10. Artemin crystal structure reveals insights into heparan sulfate binding. Silvian, L., Jin, P., Carmillo, P., Boriack-Sjodin, P.A., Pelletier, C., Rushe, M., Gong, B., Sah, D., Pepinsky, B., Rossomando, A. Biochemistry (2006) [Pubmed]
  11. GDNF family ligands activate multiple events during axonal growth in mature sensory neurons. Paveliev, M., Airaksinen, M.S., Saarma, M. Mol. Cell. Neurosci. (2004) [Pubmed]
 
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