Gene Review:
Asah1 - N-acylsphingosine amidohydrolase 1
Mus musculus
Synonyms:
2310081N20Rik, AC, ACDase, AL022942, AU044555, ...
- Purification and characterization of recombinant, human acid ceramidase. Catalytic reactions and interactions with acid sphingomyelinase. He, X., Okino, N., Dhami, R., Dagan, A., Gatt, S., Schulze, H., Sandhoff, K., Schuchman, E.H. J. Biol. Chem. (2003)
- Homozygous K5Cre transgenic mice have wavy hair and accelerated malignant progression in a murine model of skin carcinogenesis. Chan, E.L., Peace, B.E., Toney, K., Kader, S.A., Pathrose, P., Collins, M.H., Waltz, S.E. Mol. Carcinog. (2007)
- Specific and sensitive assay for alkaline and neutral ceramidases involving C12-NBD-ceramide. Tani, M., Okino, N., Mitsutake, S., Ito, M. J. Biochem. (1999)
- Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death. Strelow, A., Bernardo, K., Adam-Klages, S., Linke, T., Sandhoff, K., Krönke, M., Adam, D. J. Exp. Med. (2000)
- Increased expression of adenylylcyclase type VI proportionately increases beta-adrenergic receptor-stimulated production of cAMP in neonatal rat cardiac myocytes. Gao, M., Ping, P., Post, S., Insel, P.A., Tang, R., Hammond, H.K. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury. Llacuna, L., Marí, M., Garcia-Ruiz, C., Fernandez-Checa, J.C., Morales, A. Hepatology (2006)
- Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling. Chavez, J.A., Holland, W.L., Bär, J., Sandhoff, K., Summers, S.A. J. Biol. Chem. (2005)
- Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes. Li, C.M., Park, J.H., Simonaro, C.M., He, X., Gordon, R.E., Friedman, A.H., Ehleiter, D., Paris, F., Manova, K., Hepbildikler, S., Fuks, Z., Sandhoff, K., Kolesnick, R., Schuchman, E.H., Hepbiloikler, S. Genomics (2002)
- Sindbis virus entry into cells triggers apoptosis by activating sphingomyelinase, leading to the release of ceramide. Jan, J.T., Chatterjee, S., Griffin, D.E. J. Virol. (2000)
- Cloning and characterization of the full-length cDNA and genomic sequences encoding murine acid ceramidase. Li, C.M., Hong, S.B., Kopal, G., He, X., Linke, T., Hou, W.S., Koch, J., Gatt, S., Sandhoff, K., Schuchman, E.H. Genomics (1998)
- Neutral/alkaline and acid ceramidase activities are actively released by murine endothelial cells. Romiti, E., Meacci, E., Tani, M., Nuti, F., Farnararo, M., Ito, M., Bruni, P. Biochem. Biophys. Res. Commun. (2000)
- KLF6 is one transcription factor involved in regulating acid ceramidase gene expression. Park, J.H., Eliyahu, E., Narla, G., DiFeo, A., Martignetti, J.A., Schuchman, E.H. Biochim. Biophys. Acta (2005)
- Ceramide mediates tumor-induced dendritic cell apoptosis. Kanto, T., Kalinski, P., Hunter, O.C., Lotze, M.T., Amoscato, A.A. J. Immunol. (2001)
- Oxymetholone: II. Evaluation in the Tg-AC transgenic mouse model for detection of carcinogens. Holden, H.E., Stoll, R.E., Blanchard, K.T. Toxicologic pathology. (1999)
- Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging. Jensen, J.M., Förl, M., Winoto-Morbach, S., Seite, S., Schunck, M., Proksch, E., Schütze, S. Exp. Dermatol. (2005)
- Ceramide mediates caspase-independent programmed cell death. Thon, L., Möhlig, H., Mathieu, S., Lange, A., Bulanova, E., Winoto-Morbach, S., Schütze, S., Bulfone-Paus, S., Adam, D. FASEB J. (2005)