Gene Review:
Ugcg - UDP-glucose ceramide glucosyltransferase
Mus musculus
Synonyms:
AU043821, C80537, Ceramide glucosyltransferase, Epcs21, GCS, ...
Ichikawa,
Ozawa,
Hirabayashi,
Jennemann,
Sandhoff,
Wang,
Kiss,
Gretz,
Zuliani,
Martin-Villalba,
Jäger,
Schorle,
Kenzelmann,
Bonrouhi,
Wiegandt,
Gröne,
Ichikawa,
Ozawa,
Hirabayashi,
Ichikawa,
Ozawa,
Hirabayashi,
- Influence of cellular ganglioside depletion on tumor formation. Deng, W., Li, R., Ladisch, S. J. Natl. Cancer Inst. (2000)
- Reduction of globotriaosylceramide in Fabry disease mice by substrate deprivation. Abe, A., Gregory, S., Lee, L., Killen, P.D., Brady, R.O., Kulkarni, A., Shayman, J.A. J. Clin. Invest. (2000)
- Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action. Inokuchi, J., Jimbo, M., Momosaki, K., Shimeno, H., Nagamatsu, A., Radin, N.S. Cancer Res. (1990)
- Glycosphingolipids are required for sorting melanosomal proteins in the Golgi complex. Sprong, H., Degroote, S., Claessens, T., van Drunen, J., Oorschot, V., Westerink, B.H., Hirabayashi, Y., Klumperman, J., van der Sluijs, P., van Meer, G. J. Cell Biol. (2001)
- Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth. Jennemann, R., Sandhoff, R., Wang, S., Kiss, E., Gretz, N., Zuliani, C., Martin-Villalba, A., Jäger, R., Schorle, H., Kenzelmann, M., Bonrouhi, M., Wiegandt, H., Gröne, H.J. Proc. Natl. Acad. Sci. U.S.A. (2005)
- The expression of 11 beta-hydroxysteroid dehydrogenase type I by lymphocytes provides a novel means for intracrine regulation of glucocorticoid activities. Zhang, T.Y., Ding, X., Daynes, R.A. J. Immunol. (2005)
- Assignment1 of a UDP-glucose:ceramide glucosyltransferase gene (Ugcg) to mouse chromosome band 4B3 by in situ hybridization. Ichikawa, S., Ozawa, K., Hirabayashi, Y. Cytogenet. Cell Genet. (1998)
- Early developmental expression of the gene encoding glucosylceramide synthase, the enzyme controlling the first committed step of glycosphingolipid synthesis. Yamashita, T., Wada, R., Proia, R.L. Biochim. Biophys. Acta (2002)
- Molecular cloning and expression of mouse ceramide glucosyltransferase. Ichikawa, S., Ozawa, K., Hirabayashi, Y. Biochem. Mol. Biol. Int. (1998)
- Conditional LoxP-flanked glucosylceramide synthase allele controlling glycosphingolipid synthesis. Yamashita, T., Allende, M.L., Kalkofen, D.N., Werth, N., Sandhoff, K., Proia, R.L. Genesis (2005)
- Lactosylceramide is essential for the osteoclastogenesis mediated by macrophage-colony-stimulating factor and receptor activator of nuclear factor-kappa B ligand. Iwamoto, T., Fukumoto, S., Kanaoka, K., Sakai, E., Shibata, M., Fukumoto, E., Inokuchi Ji, J., Takamiya, K., Furukawa, K., Furukawa, K., Kato, Y., Mizuno, A. J. Biol. Chem. (2001)
- Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factors interleukin 2 and interleukin 4. Daynes, R.A., Araneo, B.A. Eur. J. Immunol. (1989)
- Caveolar structure and protein sorting are maintained in NIH 3T3 cells independent of glycosphingolipid depletion. Shu, L., Lee, L., Chang, Y., Holzman, L.B., Edwards, C.A., Shelden, E., Shayman, J.A. Arch. Biochem. Biophys. (2000)
- RNAi-mediated inhibition of the glucosylceramide synthase (GCS) gene: A preliminary study towards a therapeutic strategy for Gaucher disease and other glycosphingolipid storage diseases. Diaz-Font, A., Chab??s, A., Grinberg, D., Vilageliu, L. Blood Cells Mol. Dis. (2006)
- Molecular cloning and characterization of the mouse ceramide glucosyltransferase gene. Ichikawa, S., Ozawa, K., Hirabayashi, Y. Biochem. Biophys. Res. Commun. (1998)
- Glycolipids as immune modulatory tools. Lalazar, G., Preston, S., Zigmond, E., Y??acov, A.B., Ilan, Y. Mini reviews in medicinal chemistry (2006)
- Regulation of intracellular ceramide content in B16 melanoma cells. Biological implications of ceramide glycosylation. Komori, H., Ichikawa, S., Hirabayashi, Y., Ito, M. J. Biol. Chem. (1999)
- Ceramide mediates tumor-induced dendritic cell apoptosis. Kanto, T., Kalinski, P., Hunter, O.C., Lotze, M.T., Amoscato, A.A. J. Immunol. (2001)
- Cell cycle arrest induced by an inhibitor of glucosylceramide synthase. Correlation with cyclin-dependent kinases. Rani, C.S., Abe, A., Chang, Y., Rosenzweig, N., Saltiel, A.R., Radin, N.S., Shayman, J.A. J. Biol. Chem. (1995)
- Transient confinement of a glycosylphosphatidylinositol-anchored protein in the plasma membrane. Sheets, E.D., Lee, G.M., Simson, R., Jacobson, K. Biochemistry (1997)
- Role for up-regulated ganglioside biosynthesis and association of Src family kinases with microdomains in retinoic acid-induced differentiation of F9 embryonal carcinoma cells. Sato, T., Zakaria, A.M., Uemura, S., Ishii, A., Ohno-Iwashita, Y., Igarashi, Y., Inokuchi, J. Glycobiology (2005)
- Glycosphingolipid deficiency affects functional microdomain formation in Lewis lung carcinoma cells. Inokuchi, J.I., Uemura, S., Kabayama, K., Igarashi, Y. Glycoconj. J. (2000)
- Up-regulation of neutral glycosphingolipid synthesis upon long term inhibition of ceramide synthesis by fumonisin B1. Meivar-Levy, I., Futerman, A.H. J. Biol. Chem. (1999)
- Regulation of UDP-glucose:ceramide glucosyltransferase-1 by ceramide. Komori, H., Ichikawa, S., Hirabayashi, Y., Ito, M. FEBS Lett. (2000)
- Agents for the treatment of glycosphingolipid storage disorders. Abe, A., Wild, S.R., Lee, W.L., Shayman, J.A. Curr. Drug Metab. (2001)