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Cnbp  -  cellular nucleic acid binding protein

Mus musculus

Synonyms: AA408710, CNBP, Cellular nucleic acid-binding protein, Cnbp1, Zinc finger protein 9, ...
 
 
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Disease relevance of Cnbp

 

High impact information on Cnbp

 

Biological context of Cnbp

  • During mouse embryogenesis, CNBP is expressed in the anterior region of the early embryo and in the limb, tail and craniofacial region [4].
  • Each of the mouse clones exhibited extraordinary sequence conservation with human CNBP cDNA, and the predicted mouse amino acid sequence identities with human CNBP protein ranged from 99 to 100% [5].
  • Human cellular nucleic acid binding protein (CNBP) is a zinc finger DNA binding protein of unknown function [5].
  • Genetic mapping of CNBP genes in interspecific and intersubspecific mouse backcrosses revealed two loci that hybridize to CNBP cDNA at high stringency, located on chromosomes 5 and 6 [5].
  • These results offer novel insights into the function of CNBP during organogenesis as the regulator of forebrain formation and a number of rostral head transcription factors [6].
 

Anatomical context of Cnbp

 

Associations of Cnbp with chemical compounds

  • CNBP is mainly conformed by seven retroviral Cys-Cys-His-Cys zinc-knuckles and a glycine/arginine rich region box [8].
 

Regulatory relationships of Cnbp

 

Other interactions of Cnbp

 

Analytical, diagnostic and therapeutic context of Cnbp

References

  1. Haploinsuffciency for znf9 in znf9(+/-) mice is associated with multiorgan abnormalities resembling myotonic dystrophy. Chen, W., Wang, Y., Abe, Y., Cheney, L., Udd, B., Li, Y.P. J. Mol. Biol. (2007) [Pubmed]
  2. Identification and characterization of a JC virus pentanucleotide repeat element binding protein: cellular nucleic acid binding protein. Liu, M., Kumar, K.U., Pater, M.M., Pater, A. Virus Res. (1998) [Pubmed]
  3. The zinc-finger protein CNBP is required for forebrain formation in the mouse. Chen, W., Liang, Y., Deng, W., Shimizu, K., Ashique, A.M., Li, E., Li, Y.P. Development (2003) [Pubmed]
  4. Molecular cloning, developmental expression, promoter analysis and functional characterization of the mouse CNBP gene. Shimizu, K., Chen, W., Ashique, A.M., Moroi, R., Li, Y.P. Gene (2003) [Pubmed]
  5. Mouse cellular nucleic acid binding proteins: a highly conserved family identified by genetic mapping and sequencing. Warden, C.H., Krisans, S.K., Purcell-Huynh, D., Leete, L.M., Daluiski, A., Diep, A., Taylor, B.A., Lusis, A.J. Genomics (1994) [Pubmed]
  6. CNBP regulates forebrain formation at organogenesis stage in chick embryos. Abe, Y., Chen, W., Huang, W., Nishino, M., Li, Y.P. Dev. Biol. (2006) [Pubmed]
  7. Regulation of mouse colony-stimulating factor-1 gene promoter activity by AP1 and cellular nucleic acid-binding protein. Konicek, B.W., Xia, X., Rajavashisth, T., Harrington, M.A. DNA Cell Biol. (1998) [Pubmed]
  8. In vitro embryonic developmental phosphorylation of the cellular nucleic acid binding protein by cAMP-dependent protein kinase, and its relevance for biochemical activities. Lombardo, V.A., Armas, P., Weiner, A.M., Calcaterra, N.B. FEBS J. (2007) [Pubmed]
  9. Differential gene expression profiling between wild-type and ALAS2-null erythroblasts: identification of novel heme-regulated genes. Fujiwara, T., Harigae, H., Takahashi, S., Furuyama, K., Nakajima, O., Sun, J., Igarashi, K., Yamamoto, M., Sassa, S., Kaku, M., Sasaki, T. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
 
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