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Gene Review

Crat  -  carnitine acetyltransferase

Mus musculus

Synonyms: AW107812, CARAT, CAT, Carnitine O-acetyltransferase, Carnitine acetylase, ...
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High impact information on Crat


Biological context of Crat


Anatomical context of Crat


Associations of Crat with chemical compounds


Other interactions of Crat


Analytical, diagnostic and therapeutic context of Crat

  • Sequence analysis of the full-length cDNA clone and homology comparisons have revealed 87% homology to the human CARAT gene [2].


  1. Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity. Jogl, G., Hsiao, Y.S., Tong, L. J. Biol. Chem. (2005) [Pubmed]
  2. Cloning and characterization of murine carnitine acetyltransferase: evidence for a requirement during cell cycle progression. Brunner, S., Kramar, K., Denhardt, D.T., Hofbauer, R. Biochem. J. (1997) [Pubmed]
  3. Lipid metabolism and membrane composition are altered in the brains of type II diabetic mice. Makar, T.K., Hungund, B.L., Cook, G.A., Kashfi, K., Cooper, A.J. J. Neurochem. (1995) [Pubmed]
  4. Chromosomal locations of the mouse fatty acid oxidation genes Cpt1a, Cpt1b, Cpt2, Acadvl, and metabolically related Crat gene. Cox, K.B., Johnson, K.R., Wood, P.A. Mamm. Genome (1998) [Pubmed]
  5. Induction of cytosolic and microsomal epoxide hydrolases and proliferation of peroxisomes and mitochondria in mouse liver after dietary exposure to p-chlorophenoxyacetic acid, 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid. Lundgren, B., Meijer, J., DePierre, J.W. Biochem. Pharmacol. (1987) [Pubmed]
  6. The tumour promoter 12-O-tetradecanoylphorbol-13-acetate increases the activities of some peroxisome-associated enzymes in in vitro cell culture. Lillehaug, J.R., Berge, R.K. Br. J. Cancer (1986) [Pubmed]
  7. Localization of carnitine acyltransferases and acyl-CoA beta-oxidation enzymes in small intestinal microperoxisomes (peroxisomes) of normal and clofibrate treated mice. Small, G.M., Burdett, K., Connock, M.J. Biochem. Int. (1983) [Pubmed]
  8. Detection of acyl-CoA beta-oxidation enzymes in peroxisomes (microperoxisomes) of mouse heart. Connock, M.J., Perry, S.R. Biochem. Int. (1983) [Pubmed]
  9. Changes in cell morphology and carnitine acetyltransferase activity in Candida albicans following growth on lipids and serum and after in vivo incubation in mice. Sheridan, R., Ratledge, C. Microbiology (Reading, Engl.) (1996) [Pubmed]
  10. The effect of structurally divergent herbicides on mouse liver xenobiotic-metabolizing enzymes (P-450-dependent mono-oxygenases, epoxide hydrolases and glutathione S-transferases) and carnitine acetyltransferase. Moody, D.E., Narloch, B.A., Shull, L.R., Hammock, B.D. Toxicol. Lett. (1991) [Pubmed]
  11. Hepatotumorigenicity and peroxisome proliferation induced by the hypolipidemic CI-924 in a two-year study in male and female B6C3F1 mice. Walker, R.M., Wojcinski, Z.W., Hofstra, A.H., King, L.M., Rogers, J.E., Baker, K.W., Chang, P.K., Smith, G.S. Toxicologic pathology. (1996) [Pubmed]
  12. Choline acetyltransferase and carnitine acetyltransferase in the placenta of the mouse. Welsch, F., McCarthy, S.K. Comp. Biochem. Physiol. C, Comp. Pharmacol. (1977) [Pubmed]
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