Disease relevance of Desormone

• Enantioselective uptake and degradation of the chiral herbicide dichlorprop [(RS)-2-(2,4-dichlorophenoxy)propanoic acid] by Sphingomonas herbicidovorans MH [1].
• Correlation between toxicity tests done in aqueous medium and soil for Polytox test culture was statistically significant and yielded an r2 of 0.816 [2].
• The relative sensitivity of various aquatic organisms to nonpolar chemicals was as follows: P. subcapitata > Vibriofischeri > or = Nitrosomonas sp. > fathead minnow > Daphnia magna > polytox > activated sludge [3].
• The two enantiospecific dichlorprop/alpha-ketoglutarate-dioxygenases from Delftia acidovorans MC1--protein and sequence data of RdpA and SdpA [4].

High impact information on Desormone

• Organic nutrient enrichments shifted enantioselectivity for methyl dichlorprop ((RS)-methyl 2-(2,4-dichlorophenoxy)propionic acid) strongly towards preferentially removing the non-herbicidal enantiomer in soils from Brazil and North America, potentially increasing phytotoxicity of its residues relative to that of the racemate [5].
• The functionally important amino acid sequence motif HX(D/E)X(23-26)(T/S)X(114-183)HX(10-13)R/K, which is highly conserved in group II alpha-ketoglutarate-dependent dioxygenases, was present in both dichlorprop-cleaving enzymes [6].
• Hybridization studies comparing the wild-type plasmid and that of the mutant unable to cleave dichlorprop showed that rdpA and sdpA were deleted, whereas the lower pathway genes were unaffected, and that deletion may be caused by genetic rearrangements of the IS91-like elements [6].
• Correlations between pH and ES have previously been reported for other pesticides (metalaxyl, dichlorprop, mecoprop), but the presence or absence of such correlations is not obviously linked to the pathways of degradation [7].
• Degradation of phenoxy acids was demonstrated in microcosm experiments using groundwater and sediment contaminated with MCPP, dichlorprop, and related compounds such as other phenoxypropionic acids and chlorophenols [8].

Chemical compound and disease context of Desormone

• Sphingomonas sp. TFD44 solely degraded the dichlorinated compounds, 2,4-D, racemic 2,4-DP and 2,4-DB (2,4-dichlorophenoxybutyric acid) [9].

Biological context of Desormone

• In the presented study we wanted to establish a biological monitoring of exposure in farmers occupationally exposed to phenoxy acid herbicides (MCPA, dichlorprop mecoprop, and 2,4-D) [10].
• We have developed and optimised a simple colorimetric test protocol, based on the redox dye resazurin, in which levels of reduction of the dye are proportional to cell biomass and respiration rate in both freshly sampled municipal sludges and in a surrogate activated sludge culture, Polytox [11].
• 2-(2,4-dichlorophenoxy) propionic acid caused only mitotic recombinations [12].
• Toxicokinetics of the herbicide dichlorprop and its leucinate and their action on liver mixed function oxidase in rats [13].
• Electrophysiological analysis revealed that 2,4-D and phenoxyacetic acid were able to trigger the action potential in P. caudatum, whereas 2,4-DP and phenol failed to elicit electrical responses in this organism [14].

Anatomical context of Desormone

• The concentrations of 2,4-DP in cardiac blood, stomach contents, bile, liver, spleen, kidney and brain found by both methods were very similar [15].
• Body fluids and tissues obtained at autopsy were analysed for 2,4-DP by high-performance liquid chromatography and capillary electrophoresis [15].
• MCPP and 2,4-DP also increased cytosolic epoxide hydrolase and carnitine acetyltransferase activities suggestive of peroxisome proliferation [16].

Associations of Desormone with other chemical compounds

• Four types of soils, including sand, clay and peat, with a range in organic matter content of 0.3-13% and ten acidic pesticides of different chemical families (bentazone, bromoxynil, metsulfuron-methyl, 2,4-D, MCPA, MCPP, 2,4-DP, 2,4,5-T, 2,4-DB and MCPB) were selected as matrices and analytes, respectively [17].
• Reevaluation of published kinetic data for the herbicides dichlorprop and mecoprop indicated similar correlations between soil pH and ES as for metalaxyl [18].
• The experimental results showed that solubility of 2,4-DP, 2,4,6-TCP, and PCP is a function of pH, ionic strength, and temperature [19].
• High-performance liquid chromatography (HPLC) methods were developed for the optimised determination of five herbicide residues (dichlorprop, isoproturon, mecoprop, metsulfuron-methyl and 2,4,5-T) and major metabolites [20].
• Sorption of two phenoxy acids [(+/-)-2-(4-chloro-2-methylphenoxy) propanoic acid] (MCPP) and [(+/-)-2-(2,4-dichlorophenoxy)propanoic acid] (dichlorprop) was found to be negligible [21].

Gene context of Desormone

• R. Grace vermiculite (Ver), and Tung-Wei (Tw) soil montmorillonite were prepared to sorb or remove chlorophenoxy propionic acids (CPA) pollutants such as 2,4-dichlorophenoxy acid (2,4-DP), 2,4,6-tri chlorophenoxy acid (2,4,6-TCP), and pentachlorophenoxy propionic acid (PCP) [19].
• The inhibitory activity of the compounds against thymidylate synthetase is enhanced by the presence of apolar groups with a positive inductive effect, provided these groups do not extend the plane of the 2,4-DP ring [22].

Analytical, diagnostic and therapeutic context of Desormone

• Preparative enantiomer separation of dichlorprop with a cinchona-derived chiral selector employing centrifugal partition chromatography and high-performance liquid chromatography: a comparative study [23].
• A countercurrent chromatography protocol for support-free preparative enantiomer separation of the herbicidal agent 2-(2,4-dichlorphenoxy)propionic acid (dichlorprop) was developed utilizing a purposefully designed, highly enantioselective chiral stationary-phase additive (CSPA) derived from bis-1,4-(dihydroquinidinyl)phthalazine [23].
• Phase-modulation fluorescence lifetime immunoassay of dichlorprop [24].
• Comparison of HPLC and CE for the analysis of dichlorprop in a case of intoxication [15].
• With the aid of multidimensional scaling (MDS), a multivariate statistical method, we examined the toxicity data of five bioassays (the continuous Shk1, Polytox, activated sludge respiration inhibition, Nitrosomonas, and Tetrahymena assays) that could serve as test battery components for the assessment of wastewater toxicity to activated sludge [25].

References