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Gene Review

Crmp1  -  collapsin response mediator protein 1

Rattus norvegicus

Synonyms: CRMP-1, Collapsin response mediator protein 1, DRP-1, Dihydropyrimidinase-related protein 1, Dpysl1
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High impact information on Crmp1

  • Molecular manipulations of dynamin-like GTPases Drp1 and OPA1 that reduce dendritic mitochondria content lead to loss of synapses and dendritic spines, whereas increasing dendritic mitochondrial content or mitochondrial activity enhances the number and plasticity of spines and synapses [1].
  • Rat CRMP-2/TOAD-64 is most closely related to chick CRMP-62 and is the most widely expressed CRMP within the nervous system [2].
  • Therefore, inhibition of GSK3 alters phosphorylation of all CRMP isoforms; however, individual isoforms can be differentially regulated by their respective priming kinase [3].
  • Cypin contains zinc binding, collapsin response mediator protein (CRMP) homology, and PSD-95, Discs large, zona occludens-1 binding domains [4].
  • In addition, cypin binds tubulin via its CRMP homology domain to promote microtubule assembly [4].

Biological context of Crmp1


Anatomical context of Crmp1

  • In the N1E-115 cells, CRMP-2 has the most potent neurite elongation activity among the CRMP family members [7].
  • Although purified brain CRMP does not hydrolyze several DHPase substrates, it is likely that a related activity accounts for CRMP participation in neuronal growth cone signaling [5].
  • Both the zinc binding and CRMP homology domains are needed for dendrite patterning [4].
  • Mitochondria in DRG neurons undergo hyperglycemic mediated injury through Bim, Bax and the fission protein Drp1 [8].
  • The analysis implicates agrin and two members of the collapsin response-mediated protein (CRMP) family in the switch from precursors to Schwann cells, and synuclein-1 and alphaB-crystallin in peripheral nerve myelination [9].

Associations of Crmp1 with chemical compounds


Regulatory relationships of Crmp1


Other interactions of Crmp1


  1. The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. Li, Z., Okamoto, K., Hayashi, Y., Sheng, M. Cell (2004) [Pubmed]
  2. A family of rat CRMP genes is differentially expressed in the nervous system. Wang, L.H., Strittmatter, S.M. J. Neurosci. (1996) [Pubmed]
  3. Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo. Cole, A.R., Causeret, F., Yadirgi, G., Hastie, C.J., McLauchlan, H., McManus, E.J., Hernández, F., Eickholt, B.J., Nikolic, M., Sutherland, C. J. Biol. Chem. (2006) [Pubmed]
  4. A novel role for snapin in dendrite patterning: interaction with cypin. Chen, M., Lucas, K.G., Akum, B.F., Balasingam, G., Stawicki, T.M., Provost, J.M., Riefler, G.M., Jörnsten, R.J., Firestein, B.L. Mol. Biol. Cell (2005) [Pubmed]
  5. Brain CRMP forms heterotetramers similar to liver dihydropyrimidinase. Wang, L.H., Strittmatter, S.M. J. Neurochem. (1997) [Pubmed]
  6. The molecular mechanism of dopamine-induced apoptosis: identification and characterization of genes that mediate dopamine toxicity. Barzilai, A., Zilkha-Falb, R., Daily, D., Stern, N., Offen, D., Ziv, I., Melamed, E., Shirvan, A. J. Neural Transm. Suppl. (2000) [Pubmed]
  7. Collapsin response mediator protein-2 accelerates axon regeneration of nerve-injured motor neurons of rat. Suzuki, Y., Nakagomi, S., Namikawa, K., Kiryu-Seo, S., Inagaki, N., Kaibuchi, K., Aizawa, H., Kikuchi, K., Kiyama, H. J. Neurochem. (2003) [Pubmed]
  8. Mitochondria in DRG neurons undergo hyperglycemic mediated injury through Bim, Bax and the fission protein Drp1. Leinninger, G.M., Backus, C., Sastry, A.M., Yi, Y.B., Wang, C.W., Feldman, E.L. Neurobiol. Dis. (2006) [Pubmed]
  9. Gene profiling and bioinformatic analysis of Schwann cell embryonic development and myelination. D'Antonio, M., Michalovich, D., Paterson, M., Droggiti, A., Woodhoo, A., Mirsky, R., Jessen, K.R. Glia (2006) [Pubmed]
  10. Collapsin response mediator proteins of neonatal rat brain interact with chondroitin sulfate. Franken, S., Junghans, U., Rosslenbroich, V., Baader, S.L., Hoffmann, R., Gieselmann, V., Viebahn, C., Kappler, J. J. Biol. Chem. (2003) [Pubmed]
  11. Cellular localization and subcellular distribution of Unc-33-like protein 6, a brain-specific protein of the collapsin response mediator protein family that interacts with the neuronal glycine transporter 2. Horiuchi, M., Loebrich, S., Brandstaetter, J.H., Kneussel, M., Betz, H. J. Neurochem. (2005) [Pubmed]
  12. Expression of axon guidance molecules and their related genes during development and sexual differentiation of the olfactory bulb in rats. Tsim, T.Y., Wong, E.Y., Leung, M.S., Wong, C.C. Neuroscience (2004) [Pubmed]
  13. Phosphoproteome and transcriptome analysis of the neuronal response to a CDK5 inhibitor. Gillardon, F., Steinlein, P., Bürger, E., Hildebrandt, T., Gerner, C. Proteomics (2005) [Pubmed]
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