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Gene Review

Fanca  -  Fanconi anemia, complementation group A

Mus musculus

Synonyms: AW208693, FACA, Fanconi anemia group A protein homolog, Protein FACA
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Disease relevance of Fanca


High impact information on Fanca

  • Fanca(tm1.1Hsc) homozygotes display FA-like phenotypes including growth retardation, microphthalmia and craniofacial malformations that are not found in other Fanca mouse models, and the genetic background affects manifestation of certain phenotypes [2].
  • Fanca(tm1Hsc) homozygous males exhibited an elevated frequency of mispaired meiotic chromosomes and increased apoptosis in germ cells, implicating a role for Fanca in meiotic recombination [2].
  • To study the in vivo role of the FA group A gene (Fanca), gene-targeting techniques were used to generate Fanca(tm1Hsc) mice in which Fanca exons 1-6 were replaced by a beta-galactosidase reporter construct [2].
  • We also found a high level of Fanca expression in pachytene spermatocytes [2].
  • The characteristics of the Fancg(-/-) mice closely resemble those reported for Fancc and Fanca null mice, supporting a tight interdependence of the corresponding gene products in a common pathway [6].

Biological context of Fanca


Anatomical context of Fanca


Other interactions of Fanca

  • We show that the targeted deletion of Fanca exons 37-39 generates a null for Fanca in mice and abolishes ubiquitination of Fancd2, the downstream effector of the FA complex [3].

Analytical, diagnostic and therapeutic context of Fanca

  • By in situ hybridization, Fanca transcripts were found in the whisker follicles, teeth, brain, retina, kidney, liver, and limbs [7].
  • In addition, mouse Fancg and Fanca proteins co-purify by immunoprecipitation [10].
  • We confirmed expression and hormonal regulation of Fanca mRNA by quantitative RT-PCR, which showed that GnRH induced a rapid, transient increase in Fanca mRNA [4].
  • Finally, when animals were exposed to a fractionated total-body irradiation of 5 Gy, a similar hematopoietic syndrome was observed in wild-type and Fanca-/- mice [12].


  1. Mice with a targeted disruption of the Fanconi anemia homolog Fanca. Cheng, N.C., van de Vrugt, H.J., van der Valk, M.A., Oostra, A.B., Krimpenfort, P., de Vries, Y., Joenje, H., Berns, A., Arwert, F. Hum. Mol. Genet. (2000) [Pubmed]
  2. Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia. Wong, J.C., Alon, N., Mckerlie, C., Huang, J.R., Meyn, M.S., Buchwald, M. Hum. Mol. Genet. (2003) [Pubmed]
  3. The Fanconi anemia group A protein modulates homologous repair of DNA double-strand breaks in mammalian cells. Yang, Y.G., Herceg, Z., Nakanishi, K., Demuth, I., Piccoli, C., Michelon, J., Hildebrand, G., Jasin, M., Digweed, M., Wang, Z.Q. Carcinogenesis (2005) [Pubmed]
  4. Gonadotropin-releasing hormone regulates expression of the DNA damage repair gene, Fanconi anemia A, in pituitary gonadotroph cells. Larder, R., Chang, L., Clinton, M., Brown, P. Biol. Reprod. (2004) [Pubmed]
  5. Chemosensitizing tumor cells by targeting the Fanconi anemia pathway with an adenovirus overexpressing dominant-negative FANCA. Ferrer, M., de Winter, J.P., Mastenbroek, D.C., Curiel, D.T., Gerritsen, W.R., Giaccone, G., Kruyt, F.A. Cancer Gene Ther. (2004) [Pubmed]
  6. Reduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice. Koomen, M., Cheng, N.C., van de Vrugt, H.J., Godthelp, B.C., van der Valk, M.A., Oostra, A.B., Zdzienicka, M.Z., Joenje, H., Arwert, F. Hum. Mol. Genet. (2002) [Pubmed]
  7. Expression of the Fanconi anemia group A gene (Fanca) during mouse embryogenesis. Abu-Issa, R., Eichele, G., Youssoufian, H. Blood (1999) [Pubmed]
  8. Hematopoietic dysfunction in a mouse model for fanconi anemia group d1. Navarro, S., Meza, N.W., Quintana-Bustamante, O., Casado, J.A., Jacome, A., McAllister, K., Puerto, S., Surrallés, J., Segovia, J.C., Bueren, J.A. Mol. Ther. (2006) [Pubmed]
  9. Cloning and analysis of the mouse Fanconi anemia group A cDNA and an overlapping penta zinc finger cDNA. Wong, J.C., Alon, N., Norga, K., Kruyt, F.A., Youssoufian, H., Buchwald, M. Genomics (2000) [Pubmed]
  10. Characterization, expression and complex formation of the murine Fanconi anaemia gene product Fancg. van de Vrugt, H.J., Koomen, M., Berns, M.A., de Vries, Y., Rooimans, M.A., van der Weel, L., Blom, E., de Groot, J., Schepers, R.J., Stone, S., Hoatlin, M.E., Cheng, N.C., Joenje, H., Arwert, F. Genes Cells (2002) [Pubmed]
  11. Cloning and characterization of murine fanconi anemia group A gene: Fanca protein is expressed in lymphoid tissues, testis, and ovary. van de Vrugt, H.J., Cheng, N.C., de Vries, Y., Rooimans, M.A., de Groot, J., Scheper, R.J., Zhi, Y., Hoatlin, M.E., Joenje, H., Arwert, F. Mamm. Genome (2000) [Pubmed]
  12. Non-homologous end-joining defect in fanconi anemia hematopoietic cells exposed to ionizing radiation. Casado, J.A., Núñez, M.I., Segovia, J.C., Ruiz de Almodóvar, J.M., Bueren, J.A. Radiat. Res. (2005) [Pubmed]
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