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Gene Review

Mtpn  -  myotrophin

Mus musculus

Synonyms: 5033418D15Rik, Gcdp, Granule cell differentiation protein, Myotrophin, Protein V-1, ...
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Disease relevance of Mtpn


High impact information on Mtpn

  • The anti-PC Abs in V1(-/-) mice were heteroclitic, binding to nitrophenyl-PC better than to PC [3].
  • None of nine hybridomas produced from V1(-/-) mice provided passive protection [3].
  • Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway [5].
  • Mouse cerebellar granule cell differentiation: electrical activity regulates the GABAA receptor alpha 6 subunit gene [6].
  • (The ostensibly 'normal' meander tail posterior lobe also benefited from repletion of a more subtle granule cell deficiency.) Donor-derived neurons were well-integrated within the neuropil, suggesting that these progenitors' developmental programs for granule cell differentiation were unperturbed [7].

Chemical compound and disease context of Mtpn


Biological context of Mtpn


Anatomical context of Mtpn

  • The V-1.CP complex was detected not only in cultured cells transfected with the V-1 cDNA but also endogenously in cells as well as in murine cerebellar extracts [10].
  • In situ hybridization histochemistry revealed that the expression of the V-1 gene is transiently increased in postmigratory granule cells during postnatal rat cerebellar development and thereafter is markedly suppressed, whereas Purkinje cells constitutively express V-1 mRNA [12].
  • When rat neonatal cardiac myocytes maintained in culture were incubated with myotrophin for 30 minutes, they showed a marked increase in c-myc, c-fos, and c-jun messenger RNA levels [11].
  • Myotrophin may be involved in the upregulation of myofibrillar protein and the activation of cardiac gene transcription during growth and hypertrophy of the myocardium, and the induction of early response gene expression may be linked to this response [11].
  • In the present study we examined the distribution of V-1 mRNA in the murine central nervous system (CNS) [13].

Other interactions of Mtpn


Analytical, diagnostic and therapeutic context of Mtpn

  • An analysis of the V-1/CP interaction by surface plasmon resonance spectroscopy showed that V-1 formed a stable complex with the CP heterodimer with a dissociation constant of 1.2 x 10(-7) m and a molecular stoichiometry of approximately 1:1 [10].
  • Co-immunoprecipitation studies reveal that myotrophin/V-1 interacts with NFkappaB proteins in vitro; however, it remains physically associated only with p65 and c-Rel proteins in vivo during NFkappaB activation [16].
  • Analysis of DNA by Southern blot hybridization revealed that none of the hybridomas utilized the T15 V1 gene segment, nor did they share use of a common VDJ gene product [17].


  1. Cardiac overexpression of myotrophin triggers myocardial hypertrophy and heart failure in transgenic mice. Sarkar, S., Leaman, D.W., Gupta, S., Sil, P., Young, D., Morehead, A., Mukherjee, D., Ratliff, N., Sun, Y., Rayborn, M., Hollyfield, J., Sen, S. J. Biol. Chem. (2004) [Pubmed]
  2. Isolation of cDNA clones encoding the mouse protein V-1. Pennica, D., Shaw, K.J., Luoh, S.M., Wood, W.I. Gene (1995) [Pubmed]
  3. Highly reduced protection against Streptococcus pneumoniae after deletion of a single heavy chain gene in mouse. Mi, Q.S., Zhou, L., Schulze, D.H., Fischer, R.T., Lustig, A., Rezanka, L.J., Donovan, D.M., Longo, D.L., Kenny, J.J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice. Kim, J.Y., Nelson, A.L., Algon, S.A., Graves, O., Sturla, L.M., Goumnerova, L.C., Rowitch, D.H., Segal, R.A., Pomeroy, S.L. Dev. Biol. (2003) [Pubmed]
  5. Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway. Gazit, R., Krizhanovsky, V., Ben-Arie, N. Development (2004) [Pubmed]
  6. Mouse cerebellar granule cell differentiation: electrical activity regulates the GABAA receptor alpha 6 subunit gene. Mellor, J.R., Merlo, D., Jones, A., Wisden, W., Randall, A.D. J. Neurosci. (1998) [Pubmed]
  7. Differentiation of engrafted multipotent neural progenitors towards replacement of missing granule neurons in meander tail cerebellum may help determine the locus of mutant gene action. Rosario, C.M., Yandava, B.D., Kosaras, B., Zurakowski, D., Sidman, R.L., Snyder, E.Y. Development (1997) [Pubmed]
  8. Biological activities of the structural proteins of Japanese encephalitis virus. Takegami, T., Miyamoto, H., Nakamura, H., Yasui, K. Acta Virol. (1982) [Pubmed]
  9. A pancreatic islet-specific microRNA regulates insulin secretion. Poy, M.N., Eliasson, L., Krutzfeldt, J., Kuwajima, S., Ma, X., Macdonald, P.E., Pfeffer, S., Tuschl, T., Rajewsky, N., Rorsman, P., Stoffel, M. Nature (2004) [Pubmed]
  10. V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein. Taoka, M., Ichimura, T., Wakamiya-Tsuruta, A., Kubota, Y., Araki, T., Obinata, T., Isobe, T. J. Biol. Chem. (2003) [Pubmed]
  11. Myotrophin induces early response genes and enhances cardiac gene expression. Mukherjee, D.P., McTiernan, C.F., Sen, S. Hypertension (1993) [Pubmed]
  12. Murine cerebellar neurons express a novel gene encoding a protein related to cell cycle control and cell fate determination proteins. Taoka, M., Isobe, T., Okuyama, T., Watanabe, M., Kondo, H., Yamakawa, Y., Ozawa, F., Hishinuma, F., Kubota, M., Minegishi, A. J. Biol. Chem. (1994) [Pubmed]
  13. Murine central neurons express a novel member of the cdc10/SWI6 motif-containing protein superfamily. Fujigasaki, H., Song, S.Y., Kobayashi, T., Yamakuni, T. Brain Res. Mol. Brain Res. (1996) [Pubmed]
  14. Laminar organization of the mouse dentate gyrus: insights from BETA2/Neuro D mutant mice. Del Turco, D., Gebhardt, C., Burbach, G.J., Pleasure, S.J., Lowenstein, D.H., Deller, T. J. Comp. Neurol. (2004) [Pubmed]
  15. Differential expression and co-assembly of NMDA zeta 1 and epsilon subunits in the mouse cerebellum during postnatal development. Didier, M., Xu, M., Berman, S.A., Bursztajn, S. Neuroreport (1995) [Pubmed]
  16. Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. Knuefermann, P., Chen, P., Misra, A., Shi, S.P., Abdellatif, M., Sivasubramanian, N. J. Biol. Chem. (2002) [Pubmed]
  17. Immunologic memory to phosphocholine. VII. Lack of T15 V1 gene utilization in Xid anti-PC hybridomas. Brown, M., Stenzel-Poore, M., Rittenberg, M.B. J. Immunol. (1985) [Pubmed]
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