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Gene Review

Mn1  -  meningioma 1

Mus musculus

Synonyms: AA003644, AA009236
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Disease relevance of Mn1


High impact information on Mn1

  • We show that, beginning at four months of age, thirty percent of mice with arachnoidal cell Cre-mediated excision of Nf2 exon 2 developed a range of meningioma subtypes histologically similar to the human tumors [6].
  • Meningioma, a tumor of the meninges covering the central nervous system, shows frequent loss of material from human chromosome 22 [7].
  • Mouse antisera specific for desmosomal adhesion molecules of suprabasal skin cells, meninges, and meningioma [8].
  • In conclusion, our data suggest MN1 overexpression as a new prognostic marker in AML with normal cytogenetics [2].
  • Targeted disruption of the Mn1 oncogene results in severe defects in development of membranous bones of the cranial skeleton [1].

Chemical compound and disease context of Mn1


Biological context of Mn1


Anatomical context of Mn1


Associations of Mn1 with chemical compounds


Other interactions of Mn1


Analytical, diagnostic and therapeutic context of Mn1


  1. Targeted disruption of the Mn1 oncogene results in severe defects in development of membranous bones of the cranial skeleton. Meester-Smoor, M.A., Vermeij, M., van Helmond, M.J., Molijn, A.C., van Wely, K.H., Hekman, A.C., Vermey-Keers, C., Riegman, P.H., Zwarthoff, E.C. Mol. Cell. Biol. (2005) [Pubmed]
  2. High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics. Heuser, M., Beutel, G., Krauter, J., D??hner, K., von Neuhoff, N., Schlegelberger, B., Ganser, A. Blood (2006) [Pubmed]
  3. Detection and analysis of a glucose 6-phosphate dehydrogenase phenotype B cell line contamination. Lelbovitz, A., Wright, W.C., Pathak, S., Siciliano, M.J., Daniels, W.P. J. Natl. Cancer Inst. (1979) [Pubmed]
  4. Functional significance of S6K overexpression in meningioma progression. Surace, E.I., Lusis, E., Haipek, C.A., Gutmann, D.H. Ann. Neurol. (2004) [Pubmed]
  5. Erbin regulates mitogen-activated protein (MAP) kinase activation and MAP kinase-dependent interactions between Merlin and adherens junction protein complexes in Schwann cells. Rangwala, R., Banine, F., Borg, J.P., Sherman, L.S. J. Biol. Chem. (2005) [Pubmed]
  6. Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse. Kalamarides, M., Niwa-Kawakita, M., Leblois, H., Abramowski, V., Perricaudet, M., Janin, A., Thomas, G., Gutmann, D.H., Giovannini, M. Genes Dev. (2002) [Pubmed]
  7. The human LARGE gene from 22q12.3-q13.1 is a new, distinct member of the glycosyltransferase gene family. Peyrard, M., Seroussi, E., Sandberg-Nordqvist, A.C., Xie, Y.G., Han, F.Y., Fransson, I., Collins, J., Dunham, I., Kost-Alimova, M., Imreh, S., Dumanski, J.P. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  8. Mouse antisera specific for desmosomal adhesion molecules of suprabasal skin cells, meninges, and meningioma. Parrish, E.P., Garrod, D.R., Mattey, D.L., Hand, L., Steart, P.V., Weller, R.O. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  9. Growth inhibition of androgen-insensitive human prostate carcinoma cells by a 19-norsteroid derivative agent, mifepristone. Lin, M.F., Kawachi, M.H., Stallcup, M.R., Grunberg, S.M., Lin, F.F. Prostate (1995) [Pubmed]
  10. Hydroxyurea for treatment of unresectable and recurrent meningiomas. I. Inhibition of primary human meningioma cells in culture and in meningioma transplants by induction of the apoptotic pathway. Schrell, U.M., Rittig, M.G., Anders, M., Kiesewetter, F., Marschalek, R., Koch, U.H., Fahlbusch, R. J. Neurosurg. (1997) [Pubmed]
  11. Merlin: the neurofibromatosis 2 tumor suppressor. Gusella, J.F., Ramesh, V., MacCollin, M., Jacoby, L.B. Biochim. Biophys. Acta (1999) [Pubmed]
  12. Detailed mapping of the ERG-ETS2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16. Owczarek, C.M., Portbury, K.J., Hardy, M.P., O'Leary, D.A., Kudoh, J., Shibuya, K., Shimizu, N., Kola, I., Hertzog, P.J. Gene (2004) [Pubmed]
  13. Establishment of a benign meningioma cell line by hTERT-mediated immortalization. Püttmann, S., Senner, V., Braune, S., Hillmann, B., Exeler, R., Rickert, C.H., Paulus, W. Lab. Invest. (2005) [Pubmed]
  14. Enhanced expression of the sis and c-myc oncogenes in human meningiomas. Kazumoto, K., Tamura, M., Hoshino, H., Yuasa, Y. J. Neurosurg. (1990) [Pubmed]
  15. A follistatin-like gene, mac25, may act as a growth suppressor of osteosarcoma cells. Kato, M.V., Sato, H., Tsukada, T., Ikawa, Y., Aizawa, S., Nagayoshi, M. Oncogene (1996) [Pubmed]
  16. Hydroxyurea for treatment of unresectable and recurrent meningiomas. II. Decrease in the size of meningiomas in patients treated with hydroxyurea. Schrell, U.M., Rittig, M.G., Anders, M., Koch, U.H., Marschalek, R., Kiesewetter, F., Fahlbusch, R. J. Neurosurg. (1997) [Pubmed]
  17. Intracranial injection of human meningioma cells in athymic mice: an orthotopic model for meningioma growth. McCutcheon, I.E., Friend, K.E., Gerdes, T.M., Zhang, B.M., Wildrick, D.M., Fuller, G.N. J. Neurosurg. (2000) [Pubmed]
  18. Effect of the antiprogesterone RU-38486 on meningioma implanted into nude mice. Olson, J.J., Beck, D.W., Schlechte, J.A., Loh, P.M. J. Neurosurg. (1987) [Pubmed]
  19. Celecoxib inhibits meningioma tumor growth in a mouse xenograft model. Ragel, B.T., Jensen, R.L., Gillespie, D.L., Prescott, S.M., Couldwell, W.T. Cancer (2007) [Pubmed]
  20. Calcium channel antagonists augment hydroxyurea- and ru486-induced inhibition of meningioma growth in vivo and in vitro. Ragel, B.T., Gillespie, D.L., Kushnir, V., Polevaya, N., Kelly, D., Jensen, R.L. Neurosurgery (2006) [Pubmed]
  21. Antitumor activity of the growth hormone receptor antagonist pegvisomant against human meningiomas in nude mice. McCutcheon, I.E., Flyvbjerg, A., Hill, H., Li, J., Bennett, W.F., Scarlett, J.A., Friend, K.E. J. Neurosurg. (2001) [Pubmed]
  22. Characterisation of a new mouse monoclonal antibody (ONS-M21) reactive with both medulloblastomas and gliomas. Moriuchi, S., Shimizu, K., Miyao, Y., Hayakawa, T. Br. J. Cancer (1993) [Pubmed]
  23. Distribution of cells labelled by a monoclonal antibody (A3) against a cloned cell line derived from a rat malignant fibrous histiocytoma. Kumagai, D., Yamate, J., Tajima, T., Tsukamoto, Y., Yasui, H., Kuwamura, M., Kotani, T., Sakuma, S. J. Comp. Pathol. (2000) [Pubmed]
  24. Matrigel augments xenograft transplantation of meningioma cells into athymic mice. Jensen, R.L., Leppla, D., Rokosz, N., Wurster, R.D. Neurosurgery (1998) [Pubmed]
  25. Implantation of human meningiomas into the subrenal capsule of the nude mouse. A model for studies of tumor growth. Medhkour, A., Van Roey, M., Sobel, R.A., Fingert, H.J., Lee, J., Martuza, R.L. J. Neurosurg. (1989) [Pubmed]
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