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Gene Review

Scg2  -  secretogranin II

Rattus norvegicus

Synonyms: Chgc, Chromogranin-C, Scg-2, Secretogranin II, Secretogranin-2, ...
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Disease relevance of Scg2


Psychiatry related information on Scg2


High impact information on Scg2

  • The assay reconstitutes homotypic fusion between one population of ISGs containing a [35S]sulfate-labeled substrate, secretogranin II (SgII), and a second population containing the prohormone convertase PC2 [7].
  • Transport via the regulated secretory pathway in semi-intact PC12 cells: role of intra-cisternal calcium and pH in the transport and sorting of secretogranin II [8].
  • Addition of A23187 to release Ca2+ from the TGN had no significant effect on sorting of SgII into immature granules [8].
  • Transport via the regulated pathway, as assayed by the release of secretogranin II (SgII) labeled in the TGN, was inhibited by depletion of ATP, or by the inclusion of 100 microM GTP gamma S, 50 microM AlF3-5 or 5 micrograms/ml BFA [8].
  • Larger immature regulated secretory granules, enriched in sulfated secretogranin II, also escaped from the permeabilized cells in vitro [9].

Chemical compound and disease context of Scg2


Biological context of Scg2


Anatomical context of Scg2


Associations of Scg2 with chemical compounds


Regulatory relationships of Scg2


Other interactions of Scg2


Analytical, diagnostic and therapeutic context of Scg2

  • Age- and cycle-related changes in SgII mRNA content were estimated through cytoplasmic slot blot; SgII content was determined by western blotting; maturation of the protein was controlled through [35S]sulfate labeling [12].
  • SgII, CgA and gonadotropin alpha- and beta-subunit mRNA levels were determined by Northern blotting [14].
  • Moreover, quantitation of the newly synthesized SgII by immunoprecipitation of the 35S-labeled SgII gave evidence for a lack of E2 effect [14].
  • Therefore, pituitaries from untreated male rats were investigated by light- and electron-microscopical immunocytochemistry for the cellular and subcellular localization of CgA, CgB, and SgII [26].
  • The properties and distribution of chromogranins A, B and secretogranin II in rat brain were analyzed by quantitative immunoblotting [27].


  1. Receptor for advanced glycation end products (RAGE) signaling induces CREB-dependent chromogranin expression during neuronal differentiation. Huttunen, H.J., Kuja-Panula, J., Rauvala, H. J. Biol. Chem. (2002) [Pubmed]
  2. Distribution of chromogranins A and B and secretogranin II (secretoneurin) in rat pelvic neurons and vas deferens. Li, J.Y., Leitner, B., Winkler, H., Dahlström, A. Neuroscience (1998) [Pubmed]
  3. Expression of chromogranin/secretogranin mRNA in spontaneous mammary tumors in aging Fischer-344 rats. Umemura, S., Iwasaka, T., Osamura, R.Y. Pathol. Int. (2001) [Pubmed]
  4. A regulated secretory pathway in cultured hippocampal astrocytes. Calegari, F., Coco, S., Taverna, E., Bassetti, M., Verderio, C., Corradi, N., Matteoli, M., Rosa, P. J. Biol. Chem. (1999) [Pubmed]
  5. Immunolocalization of secretogranin II and insulin in a nerve growth factor-differentiated insulinoma cell line. Sher, E., Rosa, P., Bassetti, M., Zanini, A. Eur. J. Cell Biol. (1995) [Pubmed]
  6. Chromogranin mRNA levels in the brain as a marker for acute and chronic changes in neuronal activity: effect of treatments including seizures, osmotic stimulation and axotomy in the rat. Shen, P.J., Gundlach, A.L. Eur. J. Neurosci. (1996) [Pubmed]
  7. Homotypic fusion of immature secretory granules during maturation in a cell-free assay. Urbé, S., Page, L.J., Tooze, S.A. J. Cell Biol. (1998) [Pubmed]
  8. Transport via the regulated secretory pathway in semi-intact PC12 cells: role of intra-cisternal calcium and pH in the transport and sorting of secretogranin II. Carnell, L., Moore, H.P. J. Cell Biol. (1994) [Pubmed]
  9. Intermediates in the constitutive and regulated secretory pathways released in vitro from semi-intact cells. Grimes, M., Kelly, R.B. J. Cell Biol. (1992) [Pubmed]
  10. Transcriptional regulation of secretogranin II and chromogranin B by cyclic AMP in a rat pheochromocytoma cell line. Thompson, M.E., Valentine, D.L., Strada, S.J., Wagner, J.A., Scammell, J.G. Mol. Pharmacol. (1994) [Pubmed]
  11. Polyethylene glycol-induced hypovolemia affects the expression of MCH mRNA, but not dynorphin or secretogranin II mRNAs, in the rat lateral hypothalamus. Hervé, C., Colard, C., Grillon, S., Fellmann, D., Griffond, B. Neurosci. Lett. (1998) [Pubmed]
  12. Differential expression of secretogranin II and chromogranin A genes in the female rat pituitary through sexual maturation and estrous cycle. Anouar, Y., Duval, J. Endocrinology (1991) [Pubmed]
  13. Differential regulation of chromogranin A, chromogranin B and secretogranin II in rat brain by phencyclidine treatment. Marksteiner, J., Weiss, U., Weis, C., Laslop, A., Fischer-Colbrie, R., Humpel, C., Feldon, J., Fleischhacker, W.W. Neuroscience (2001) [Pubmed]
  14. Direct estradiol down-regulation of secretogranin II and chromogranin A mRNA levels in rat pituitary cells. Anouar, Y., Duval, J. Mol. Cell. Endocrinol. (1992) [Pubmed]
  15. Estradiol negatively regulates secretogranin II and chromogranin A messenger ribonucleic acid levels in the female rat pituitary but not in the adrenal. Anouar, Y., Benie, T., De Monti, M., Counis, R., Duval, J. Endocrinology (1991) [Pubmed]
  16. Differential increases in chromogranins, but not synapsin I, in cortical neurons following spreading depression: implications for functional roles and transmitter peptide release. Shen, P.J., Gundlach, A.L. Eur. J. Neurosci. (1998) [Pubmed]
  17. Differential effects of phencyclidine application on secretogranin II expression in organotypic slices of rat prefrontal cortex. Hinterhoelzl, J.K., Salimi, K., Humpel, C., Singewald, N., Adlassnig, C., Fischer-Colbrie, R., Fleischhacker, W.W., Marksteiner, J. J. Neurochem. (2003) [Pubmed]
  18. Chromogranins in temporal lobe epilepsy. Kandlhofer, S., Hoertnagl, B., Czech, T., Baumgartner, C., Maier, H., Novak, K., Sperk, G. Epilepsia (2000) [Pubmed]
  19. Secretory granules and granins in hyperstimulated male rat gonadotropes. Watanabe, T., Jeziorowski, T., Wuttke, W., Grube, D. J. Histochem. Cytochem. (1993) [Pubmed]
  20. Further evidence that behavioral tests and neuropeptide mRNA and tissue level alterations can differentiate between typical and atypical antipsychotic drugs. Bauer, R., Mayr, A., Lederer, W., Needham, P.L., Kilpatrick, I.C., Fleischhacker, W.W., Marksteiner, J. Neuropsychopharmacology (2000) [Pubmed]
  21. Gonadotropin-releasing hormone-induced stimulation of the rat secretogranin II promoter involves activation of CREB. Song, S.B., Rhee, M., Roberson, M.S., Maurer, R.A., Kim, K.E. Mol. Cell. Endocrinol. (2003) [Pubmed]
  22. Real-time imaging of the axonal transport of granules containing a tissue plasminogen activator/green fluorescent protein hybrid. Lochner, J.E., Kingma, M., Kuhn, S., Meliza, C.D., Cutler, B., Scalettar, B.A. Mol. Biol. Cell (1998) [Pubmed]
  23. Alteration of dynorphin and secretogranin II in the prolactin immunoreactive neurons of the rat lateral hypothalamus upon osmotic stimulation. Grillon, S., Griffond, B., Fellmann, D. Neurosci. Lett. (1996) [Pubmed]
  24. Regulation of expression of secretogranin II mRNA in female rat pituitary and hypothalamus. Kakar, S.S., Wei, N., Mulchahey, J.J., LeBoeuf, R.D., Neill, J.D. Neuroendocrinology (1993) [Pubmed]
  25. Effects of nerve growth factor on the biosynthesis of chromogranin A and B, secretogranin II and carboxypeptidase H in rat PC12 cells. Laslop, A., Tschernitz, C. Neuroscience (1992) [Pubmed]
  26. Topology of chromogranin A and secretogranin II in the rat anterior pituitary: potential marker proteins for distinct secretory pathways in gonadotrophs. Watanabe, T., Uchiyama, Y., Grube, D. Histochemistry (1991) [Pubmed]
  27. Chromogranins in rat brain: characterization, topographical distribution and regulation of synthesis. Weiler, R., Marksteiner, J., Bellmann, R., Wohlfarter, T., Schober, M., Fischer-Colbrie, R., Sperk, G., Winkler, H. Brain Res. (1990) [Pubmed]
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