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Gene Review

SEMA3A  -  sema domain, immunoglobulin domain (Ig),...

Homo sapiens

Synonyms: COLL1, HH16, Hsema-I, Hsema-III, SEMA1, ...
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Disease relevance of SEMA3A


Psychiatry related information on SEMA3A

  • OBJECTIVE: To identify and compare the patterns of cerebral atrophy associated with two clinical variants of frontotemporal lobar degeneration (FTLD): frontotemporal dementia (FTD) and semantic dementia (SemD) [5].
  • The authors suggest that pathology in the areas of atrophy associated with both FTD and SemD may underlie some the behavioral symptoms seen in the two disorders [5].
  • METHODS: The authors asked patients with progressive nonfluent aphasia (PNFA), patients with semantic dementia (SemD), and nonaphasic patients with a disorder of social comportment and executive functioning (SOC/EXEC) to narrate the story of a wordless children's picture book [6].

High impact information on SEMA3A

  • Both the sema portion and the remainder of the ectodomain of PlexinA1 associate with NP1 in a Sema3A-independent fashion [7].
  • Winberg et al. present evidence that the transmembrane protein Off-track (OTK) interacts biochemically and genetically with Plexin A and is important for Sema 1a repulsive signaling [8].
  • Sema-deleted PlexinA1 is constitutively active, producing cell contraction, growth cone collapse, and inhibition of neurite outgrowth [7].
  • The coagulation factor domains alone are necessary and sufficient for binding of the Sema III immunoglobulin- (Ig-) basic domain and the unrelated ligand, vascular endothelial growth factor (VEGF) [9].
  • Enteroaggregative Escherichia coll and outbreaks of gastroenteritis in UK [10].

Chemical compound and disease context of SEMA3A


Biological context of SEMA3A


Anatomical context of SEMA3A

  • We have employed an expression cloning strategy to search for axon repellents secreted by the notochord, and have identified SEMA3A as a candidate repellent [14].
  • In contrast to most previously described semaphorins, sema K1 is only weakly expressed during development but is present at high levels in postnatal and adult tissues, particularly brain and spinal cord [15].
  • We report that a factor secreted in the umbilical cord induces the collapse of neurite growth cones in vitro and provide evidence that this factor is Sema 3A [16].
  • In summary, our results suggest that the chemorepulsive signals mediated by Sema 3A play an important role in preventing nerve fibers growth in the umbilical cord and in gestational uterine tissues [16].
  • It turns out that paracrine secretion of class 3 SEMA (SEMA3) by nonendothelial tissues cooperates with vascular endothelial growth factor in regulating EC precursor migration and assembly during vasculogenesis and funnels navigating blood vessel through tissue boundaries during sprouting angiogenesis [17].

Associations of SEMA3A with chemical compounds

  • TSA and SAHA upregulated the expression by HUVEC of semaphorin III, a recently described VEGF competitor, at both mRNA and protein levels [18].
  • Indeed, signaling from SEMA-activated plexin receptors negatively regulates cell-ECM adhesive interactions by inhibiting two key integrin activators, such as the small GTPase R-Ras and the focal adhesion protein talin [17].
  • We show that three different GSK-3 antagonists (LiCl, SB-216763, and SB-415286) can inhibit the growth cone collapse response induced by Sema 3A [19].
  • The sema domain was first defined from sequence by Kolodkin and colleagues in the early 1990s, and constitutes the distinctive structural and functional element of semaphorins, their plexin receptors and the receptor tyrosine kinases MET and RON, three protein families with major roles in development, tissue regeneration and cancer [20].
  • Mutation of cysteine 723, one of four conserved cysteine residues in the 33-kDa fragment, revealed its requirement both for the dimerization of SemD and its chemorepulsive activity [21].

Physical interactions of SEMA3A


Other interactions of SEMA3A


Analytical, diagnostic and therapeutic context of SEMA3A

  • To determine whether skeletal unloading also induced resistance to GH, we evaluated the response of the femur and humerus of sham and hypophysectomized rats, control and hind limb elevated, to GH (two doses), measuring mRNA levels of IGF-I, BGP, rat bone alkaline phosphatase (RAP), and alpha 1(1)-procollagen (coll) [24].
  • Retrograde tracing combined with in situ hybridization also revealed that the staining of semaIII/coll-1 within the entorhinal cortex was present in the stellate neurons that project via the perforant path to the molecular layer of the dentate gyrus [25].
  • From the comparison between glass transition (T'g) and collapse (T coll) temperatures, we concluded that the collapse temperature was a more relevant parameter than T'g for freeze-drying cycle development and optimisation [26].
  • Furthermore, human cartilage proteoglycans and II coll, assayed by specific radioimmunoassays, are released into the culture medium and constitute the new matrix of the clusters [27].


  1. Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins. Rieger, J., Wick, W., Weller, M. Glia (2003) [Pubmed]
  2. Loss of inhibitory semaphorin 3A (SEMA3A) autocrine loops in bone marrow endothelial cells of patients with multiple myeloma. Vacca, A., Scavelli, C., Serini, G., Di Pietro, G., Cirulli, T., Merchionne, F., Ribatti, D., Bussolino, F., Guidolin, D., Piaggio, G., Bacigalupo, A., Dammacco, F. Blood (2006) [Pubmed]
  3. Expression of semaphorins, vascular endothelial growth factor, and their common receptor neuropilins and alleic loss of semaphorin locus in epithelial ovarian neoplasms: increased ratio of vascular endothelial growth factor to semaphorin is a poor prognostic factor in ovarian carcinomas. Osada, R., Horiuchi, A., Kikuchi, N., Ohira, S., Ota, M., Katsuyama, Y., Konishi, I. Hum. Pathol. (2006) [Pubmed]
  4. Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancer. Xiang, R.H., Hensel, C.H., Garcia, D.K., Carlson, H.C., Kok, K., Daly, M.C., Kerbacher, K., van den Berg, A., Veldhuis, P., Buys, C.H., Naylor, S.L. Genomics (1996) [Pubmed]
  5. Patterns of brain atrophy in frontotemporal dementia and semantic dementia. Rosen, H.J., Gorno-Tempini, M.L., Goldman, W.P., Perry, R.J., Schuff, N., Weiner, M., Feiwell, R., Kramer, J.H., Miller, B.L. Neurology (2002) [Pubmed]
  6. Trying to tell a tale: discourse impairments in progressive aphasia and frontotemporal dementia. Ash, S., Moore, P., Antani, S., McCawley, G., Work, M., Grossman, M. Neurology (2006) [Pubmed]
  7. Plexina1 autoinhibition by the plexin sema domain. Takahashi, T., Strittmatter, S.M. Neuron (2001) [Pubmed]
  8. Plexin signaling via off-track and rho family GTPases. Whitford, K.L., Ghosh, A. Neuron (2001) [Pubmed]
  9. Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity. Giger, R.J., Urquhart, E.R., Gillespie, S.K., Levengood, D.V., Ginty, D.D., Kolodkin, A.L. Neuron (1998) [Pubmed]
  10. Enteroaggregative Escherichia coll and outbreaks of gastroenteritis in UK. Smith, H.R., Cheasty, T., Rowe, B. Lancet (1997) [Pubmed]
  11. Clinical applications of a new parenteral antibiotic in the treatment of severe bacterial infections. Holloway, W.J., Palmer, D. Am. J. Med. (1996) [Pubmed]
  12. Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns. Sekido, Y., Bader, S., Latif, F., Chen, J.Y., Duh, F.M., Wei, M.H., Albanesi, J.P., Lee, C.C., Lerman, M.I., Minna, J.D. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  13. Semaphorin 3C regulates endothelial cell function by increasing integrin activity. Banu, N., Teichman, J., Dunlap-Brown, M., Villegas, G., Tufro, A. FASEB J. (2006) [Pubmed]
  14. Molecular analysis of axon repulsion by the notochord. Anderson, C.N., Ohta, K., Quick, M.M., Fleming, A., Keynes, R., Tannahill, D. Development (2003) [Pubmed]
  15. Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins. Xu, X., Ng, S., Wu, Z.L., Nguyen, D., Homburger, S., Seidel-Dugan, C., Ebens, A., Luo, Y. J. Biol. Chem. (1998) [Pubmed]
  16. Restricted innervation of uterus and placenta during pregnancy: evidence for a role of the repelling signal Semaphorin 3A. Marzioni, D., Tamagnone, L., Capparuccia, L., Marchini, C., Amici, A., Todros, T., Bischof, P., Neidhart, S., Grenningloh, G., Castellucci, M. Dev. Dyn. (2004) [Pubmed]
  17. Semaphoring vascular morphogenesis. Bussolino, F., Valdembri, D., Caccavari, F., Serini, G. Endothelium (2006) [Pubmed]
  18. Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. Deroanne, C.F., Bonjean, K., Servotte, S., Devy, L., Colige, A., Clausse, N., Blacher, S., Verdin, E., Foidart, J.M., Nusgens, B.V., Castronovo, V. Oncogene (2002) [Pubmed]
  19. An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling. Eickholt, B.J., Walsh, F.S., Doherty, P. J. Cell Biol. (2002) [Pubmed]
  20. The sema domain. Gherardi, E., Love, C.A., Esnouf, R.M., Jones, E.Y. Curr. Opin. Struct. Biol. (2004) [Pubmed]
  21. The chemorepulsive activity of the axonal guidance signal semaphorin D requires dimerization. Klostermann, A., Lohrum, M., Adams, R.H., Püschel, A.W. J. Biol. Chem. (1998) [Pubmed]
  22. Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regeneration. Sandvig, A., Berry, M., Barrett, L.B., Butt, A., Logan, A. Glia (2004) [Pubmed]
  23. Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells. Bachelder, R.E., Lipscomb, E.A., Lin, X., Wendt, M.A., Chadborn, N.H., Eickholt, B.J., Mercurio, A.M. Cancer Res. (2003) [Pubmed]
  24. The molecular response of bone to growth hormone during skeletal unloading: regional differences. Bikle, D.D., Harris, J., Halloran, B.P., Currier, P.A., Tanner, S., Morey-Holton, E. Endocrinology (1995) [Pubmed]
  25. Anatomical distribution of the chemorepellent semaphorin III/collapsin-1 in the adult rat and human brain: predominant expression in structures of the olfactory-hippocampal pathway and the motor system. Giger, R.J., Pasterkamp, R.J., Heijnen, S., Holtmaat, A.J., Verhaagen, J. J. Neurosci. Res. (1998) [Pubmed]
  26. Physical characterisation of formulations for the development of two stable freeze-dried proteins during both dried and liquid storage. Passot, S., Fonseca, F., Alarcon-Lorca, M., Rolland, D., Marin, M. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V. (2005) [Pubmed]
  27. Effects of hormones and drugs on cartilage repair. Franchimont, P., Bassleer, C., Henrotin, Y. The Journal of rheumatology. Supplement. (1989) [Pubmed]
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