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Gene Review

Ubtf  -  upstream binding transcription factor, RNA...

Mus musculus

Synonyms: A930005G04Rik, NOR-90, Nucleolar transcription factor 1, Tcfubf, UBF, ...
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Disease relevance of Ubtf


High impact information on Ubtf


Biological context of Ubtf


Anatomical context of Ubtf

  • In contrast, PES1 and UBF1 can transform mouse embryo fibroblasts that have high levels of endogenous IRS-1 and are not prone to differentiation [8].
  • We have investigated the effects of PES1 and UBF1 on the growth and differentiation of cell lines derived from 32D cells, an interleukin-3 (IL-3)-dependent murine myeloid cell line [8].
  • 32D IGF-IR cells expressing PES1 or UBF1 differentiate into granulocytes like their parental cells [8].
  • We show that rDNA transcription, rRNA synthesis and UBF expression in left ventricular myocytes isolated from mice 1-6 weeks following transverse aortic constriction were significantly increased (2.5-3.5-fold) compared to the levels in myocytes from the left ventricle of sham-operated mice [1].
  • To assess the role of acetylation in regulation of UBF activity, we have established an NIH3T3 cell line that inducibly overexpresses HDAC1 [10].

Associations of Ubtf with chemical compounds

  • NDH II migrated out of the nucleolus after administration of 0.05 microg/ml actinomycin D, while nucleolin and the upstream binding factor (UBF) remained there [11].
  • Phosphorylation occurs on a number of UBF1 peptides, most prominently on the highly acidic, serine-rich C terminus [12].

Physical interactions of Ubtf


Other interactions of Ubtf


Analytical, diagnostic and therapeutic context of Ubtf

  • These findings demonstrate that IGF-IR signaling can increase the activity of UBF1 and transcription from the rDNA promoter, providing one explanation for the reported effects of the IGF/IRS-1 axis on cell and body size in animals and cells in culture [12].
  • Nuclear run-on assays and Northern blot analyses demonstrated that the UBF gene was a primary response gene, exhibiting characteristics similar to those of c-myc and SRF [13].


  1. Cardiac hypertrophy in vivo is associated with increased expression of the ribosomal gene transcription factor UBF. Brandenburger, Y., Arthur, J.F., Woodcock, E.A., Du, X.J., Gao, X.M., Autelitano, D.J., Rothblum, L.I., Hannan, R.D. FEBS Lett. (2003) [Pubmed]
  2. Growth factor signaling regulates elongation of RNA polymerase I transcription in mammals via UBF phosphorylation and r-chromatin remodeling. Stefanovsky, V., Langlois, F., Gagnon-Kugler, T., Rothblum, L.I., Moss, T. Mol. Cell (2006) [Pubmed]
  3. Molecular mechanisms mediating methylation-dependent silencing of ribosomal gene transcription. Santoro, R., Grummt, I. Mol. Cell (2001) [Pubmed]
  4. Functional differences between the two splice variants of the nucleolar transcription factor UBF: the second HMG box determines specificity of DNA binding and transcriptional activity. Kuhn, A., Voit, R., Stefanovsky, V., Evers, R., Bianchi, M., Grummt, I. EMBO J. (1994) [Pubmed]
  5. The HMG box-containing nucleolar transcription factor UBF interacts with a specific subunit of RNA polymerase I. Schnapp, G., Santori, F., Carles, C., Riva, M., Grummt, I. EMBO J. (1994) [Pubmed]
  6. Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase. Drakas, R., Tu, X., Baserga, R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  7. mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF. Hannan, K.M., Brandenburger, Y., Jenkins, A., Sharkey, K., Cavanaugh, A., Rothblum, L., Moss, T., Poortinga, G., McArthur, G.A., Pearson, R.B., Hannan, R.D. Mol. Cell. Biol. (2003) [Pubmed]
  8. Role of pescadillo and upstream binding factor in the proliferation and differentiation of murine myeloid cells. Prisco, M., Maiorana, A., Guerzoni, C., Calin, G., Calabretta, B., Voit, R., Grummt, I., Baserga, R. Mol. Cell. Biol. (2004) [Pubmed]
  9. Functional and molecular reorganization of the nucleolar apparatus in maturing mouse oocytes. Zatsepina, O.V., Bouniol-Baly, C., Amirand, C., Debey, P. Dev. Biol. (2000) [Pubmed]
  10. Acetylation of UBF changes during the cell cycle and regulates the interaction of UBF with RNA polymerase I. Meraner, J., Lechner, M., Loidl, A., Goralik-Schramel, M., Voit, R., Grummt, I., Loidl, P. Nucleic Acids Res. (2006) [Pubmed]
  11. Nuclear DNA helicase II (RNA helicase A) binds to an F-actin containing shell that surrounds the nucleolus. Zhang, S., Köhler, C., Hemmerich, P., Grosse, F. Exp. Cell Res. (2004) [Pubmed]
  12. Regulation of upstream binding factor 1 activity by insulin-like growth factor I receptor signaling. Wu, A., Tu, X., Prisco, M., Baserga, R. J. Biol. Chem. (2005) [Pubmed]
  13. The RNA polymerase I transcription factor UBF is the product of a primary response gene. Glibetic, M., Taylor, L., Larson, D., Hannan, R., Sells, B., Rothblum, L. J. Biol. Chem. (1995) [Pubmed]
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