Gene Review:
Rps6kb1 - ribosomal protein S6 kinase, polypeptide 1
Mus musculus
Synonyms:
2610318I15Rik, 4732464A07Rik, 70 kDa ribosomal protein S6 kinase 1, 70kDa, AA959758, ...
- The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. Harrington, L.S., Findlay, G.M., Gray, A., Tolkacheva, T., Wigfield, S., Rebholz, H., Barnett, J., Leslie, N.R., Cheng, S., Shepherd, P.R., Gout, I., Downes, C.P., Lamb, R.F. J. Cell Biol. (2004)
- Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy. McMullen, J.R., Shioi, T., Zhang, L., Tarnavski, O., Sherwood, M.C., Dorfman, A.L., Longnus, S., Pende, M., Martin, K.A., Blenis, J., Thomas, G., Izumo, S. Mol. Cell. Biol. (2004)
- A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Kwiatkowski, D.J., Zhang, H., Bandura, J.L., Heiberger, K.M., Glogauer, M., el-Hashemite, N., Onda, H. Hum. Mol. Genet. (2002)
- Suppression of PI3K/mTOR pathway rescues LLC cells from cell death induced by hypoxia. Hamanaka, Y., Mukai, M., Shimamura, M., Kitagawa, T., Nishida, T., Isohashi, F., Ito, T., Nishizawa, Y., Tatsuta, M., Matsuda, H., Inoue, M. Biochem. Biophys. Res. Commun. (2005)
- Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Um, S.H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P.R., Kozma, S.C., Auwerx, J., Thomas, G. Nature (2004)
- The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1. Chou, M.M., Blenis, J. Cell (1996)
- EGF induces biphasic S6 kinase activation: late phase is protein kinase C-dependent and contributes to mitogenicity. Susa, M., Olivier, A.R., Fabbro, D., Thomas, G. Cell (1989)
- Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice. Pende, M., Kozma, S.C., Jaquet, M., Oorschot, V., Burcelin, R., Le Marchand-Brustel, Y., Klumperman, J., Thorens, B., Thomas, G. Nature (2000)
- Activation of p70/p85 S6 kinase by a pathway independent of p21ras. Ming, X.F., Burgering, B.M., Wennström, S., Claesson-Welsh, L., Heldin, C.H., Bos, J.L., Kozma, S.C., Thomas, G. Nature (1994)
- MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways. Ballou, L.M., Luther, H., Thomas, G. Nature (1991)
- Participation of a MEK-independent pathway in MAP kinase activation and modulation of cell growth in mouse hepatoma cell lines. Saeki, Y., Hazeki, K., Hazeki, O., Ui, M., Itoh, K., Matsumoto, M., Toyoshima, K., Akedo, H., Seya, T. Int. J. Mol. Med. (2000)
- Vascular hypertrophy and increased P70S6 kinase in mice lacking the angiotensin II AT(2) receptor. Brede, M., Hadamek, K., Meinel, L., Wiesmann, F., Peters, J., Engelhardt, S., Simm, A., Haase, A., Lohse, M.J., Hein, L. Circulation (2001)
- Role of S6 phosphorylation and S6 kinase in cell growth. Volarević, S., Thomas, G. Prog. Nucleic Acid Res. Mol. Biol. (2001)
- S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Pende, M., Um, S.H., Mieulet, V., Sticker, M., Goss, V.L., Mestan, J., Mueller, M., Fumagalli, S., Kozma, S.C., Thomas, G. Mol. Cell. Biol. (2004)
- Translational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities. Khaleghpour, K., Pyronnet, S., Gingras, A.C., Sonenberg, N. Mol. Cell. Biol. (1999)
- mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF. Hannan, K.M., Brandenburger, Y., Jenkins, A., Sharkey, K., Cavanaugh, A., Rothblum, L., Moss, T., Poortinga, G., McArthur, G.A., Pearson, R.B., Hannan, R.D. Mol. Cell. Biol. (2003)
- M-CSF, TNFalpha and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase. Glantschnig, H., Fisher, J.E., Wesolowski, G., Rodan, G.A., Reszka, A.A. Cell Death Differ. (2003)
- Mechanism of ribosomal p70S6 kinase activation by granulocyte macrophage colony-stimulating factor in neutrophils: cooperation of a MEK-related, THR421/SER424 kinase and a rapamycin-sensitive, m-TOR-related THR389 kinase. Lehman, J.A., Calvo, V., Gomez-Cambronero, J. J. Biol. Chem. (2003)
- Role of the p70(S6K) pathway in regulating the actin cytoskeleton and cell migration. Berven, L.A., Willard, F.S., Crouch, M.F. Exp. Cell Res. (2004)
- Signaling in lipopolysaccharide-induced stabilization of formyl Peptide receptor 1 mRNA in mouse peritoneal macrophages. Mandal, P., Hamilton, T. J. Immunol. (2007)
- mu-Opioid receptor activates signaling pathways implicated in cell survival and translational control. Polakiewicz, R.D., Schieferl, S.M., Gingras, A.C., Sonenberg, N., Comb, M.J. J. Biol. Chem. (1998)
- Glutamatergic regulation of the p70S6 kinase in primary mouse neurons. Lenz, G., Avruch, J. J. Biol. Chem. (2005)
- Selective inhibition of p70 S6 kinase activation by phosphatidylinositol 3-kinase inhibitors. Petritsch, C., Woscholski, R., Edelmann, H.M., Parker, P.J., Ballou, L.M. Eur. J. Biochem. (1995)
- Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation. Uhlmann, E.J., Li, W., Scheidenhelm, D.K., Gau, C.L., Tamanoi, F., Gutmann, D.H. Glia (2004)
- Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes. MacKenzie, S.J., Yarwood, S.J., Peden, A.H., Bolger, G.B., Vernon, R.G., Houslay, M.D. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Involvement of p70 S6 kinase in bone morphogenetic protein signaling: vascular endothelial growth factor synthesis by bone morphogenetic protein-4 in osteoblasts. Kozawa, O., Matsuno, H., Uematsu, T. J. Cell. Biochem. (2001)
- Cdc42 promotes G1 progression through p70 S6 kinase-mediated induction of cyclin E expression. Chou, M.M., Masuda-Robens, J.M., Gupta, M.L. J. Biol. Chem. (2003)
- The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase. Ganesan, L.P., Wei, G., Pengal, R.A., Moldovan, L., Moldovan, N., Ostrowski, M.C., Tridandapani, S. J. Biol. Chem. (2004)
- Impact of Src homology 2-containing inositol 5'-phosphatase 2 on the regulation of insulin signaling leading to protein synthesis in 3T3-L1 adipocytes cultured with excess amino acids. Murakami, S., Sasaoka, T., Wada, T., Fukui, K., Nagira, K., Ishihara, H., Usui, I., Kobayashi, M. Endocrinology (2004)
- Involvement of the Akt/mTOR pathway on EGF-induced cell transformation. Nomura, M., He, Z., Koyama, I., Ma, W.Y., Miyamoto, K., Dong, Z. Mol. Carcinog. (2003)
- Requirement of phosphatidylinositol 3-kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival activities in NIH 3T3 fibroblasts. Goruppi, S., Ruaro, E., Varnum, B., Schneider, C. Mol. Cell. Biol. (1997)
- In vivo role of the phosphate groove of PDK1 defined by knockin mutation. Collins, B.J., Deak, M., Murray-Tait, V., Storey, K.G., Alessi, D.R. J. Cell. Sci. (2005)
- Inhibition of insulin signaling and adipogenesis by rapamycin: effect on phosphorylation of p70 S6 kinase vs eIF4E-BP1. El-Chaâr, D., Gagnon, A., Sorisky, A. Int. J. Obes. Relat. Metab. Disord. (2004)
- Protein kinase A-dependent and -independent signaling pathways contribute to cyclic AMP-stimulated proliferation. Cass, L.A., Summers, S.A., Prendergast, G.V., Backer, J.M., Birnbaum, M.J., Meinkoth, J.L. Mol. Cell. Biol. (1999)
- Requirement for phosphoinositide 3-OH kinase in growth hormone signalling to the mitogen-activated protein kinase and p70s6k pathways. Kilgour, E., Gout, I., Anderson, N.G. Biochem. J. (1996)
- Functional analysis of PIK3CA gene mutations in human colorectal cancer. Ikenoue, T., Kanai, F., Hikiba, Y., Obata, T., Tanaka, Y., Imamura, J., Ohta, M., Jazag, A., Guleng, B., Tateishi, K., Asaoka, Y., Matsumura, M., Kawabe, T., Omata, M. Cancer Res. (2005)
- Differential effects of des IGF-1 on Erks, AKT-1 and P70 S6K activation in mouse skeletal and cardiac muscle. Li, M., Li, C., Parkhouse, W.S. Mol. Cell. Biochem. (2002)