Gene Review:
Irs1 - insulin receptor substrate 1
Mus musculus
Synonyms:
G972R, IRS-1, Insulin receptor substrate 1, Irs-1
- Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. Dong, X., Park, S., Lin, X., Copps, K., Yi, X., White, M.F. J. Clin. Invest. (2006)
- Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover. Ogata, N., Chikazu, D., Kubota, N., Terauchi, Y., Tobe, K., Azuma, Y., Ohta, T., Kadowaki, T., Nakamura, K., Kawaguchi, H. J. Clin. Invest. (2000)
- Suppression of Insulin Receptor Substrate 1 (IRS-1) Promotes Mammary Tumor Metastasis. Ma, Z., Gibson, S.L., Byrne, M.A., Zhang, J., White, M.F., Shaw, L.M. Mol. Cell. Biol. (2006)
- Nuclear translocation of insulin receptor substrate-1 by oncogenes and Igf-I. Effect on ribosomal RNA synthesis. Tu, X., Batta, P., Innocent, N., Prisco, M., Casaburi, I., Belletti, B., Baserga, R. J. Biol. Chem. (2002)
- Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Withers, D.J., Burks, D.J., Towery, H.H., Altamuro, S.L., Flint, C.L., White, M.F. Nat. Genet. (1999)
- Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Brüning, J.C., Winnay, J., Bonner-Weir, S., Taylor, S.I., Accili, D., Kahn, C.R. Cell (1997)
- Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. Bard-Chapeau, E.A., Hevener, A.L., Long, S., Zhang, E.E., Olefsky, J.M., Feng, G.S. Nat. Med. (2005)
- Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Araki, E., Lipes, M.A., Patti, M.E., Brüning, J.C., Haag, B., Johnson, R.S., Kahn, C.R. Nature (1994)
- IRS1 degradation and increased serine phosphorylation cannot predict the degree of metabolic insulin resistance induced by oxidative stress. Potashnik, R., Bloch-Damti, A., Bashan, N., Rudich, A. Diabetologia (2003)
- Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance. Shintani, Y., Fujie, H., Miyoshi, H., Tsutsumi, T., Tsukamoto, K., Kimura, S., Moriya, K., Koike, K. Gastroenterology (2004)
- Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction. Sakoda, H., Ogihara, T., Anai, M., Funaki, M., Inukai, K., Katagiri, H., Fukushima, Y., Onishi, Y., Ono, H., Fujishiro, M., Kikuchi, M., Oka, Y., Asano, T. Diabetes (2000)
- Heterozygous knockout of the IRS-1 gene in mice enhances obesity-linked insulin resistance: a possible model for the development of type 2 diabetes. Shirakami, A., Toyonaga, T., Tsuruzoe, K., Shirotani, T., Matsumoto, K., Yoshizato, K., Kawashima, J., Hirashima, Y., Miyamura, N., Kahn, C.R., Araki, E. J. Endocrinol. (2002)
- Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. Laustsen, P.G., Michael, M.D., Crute, B.E., Cohen, S.E., Ueki, K., Kulkarni, R.N., Keller, S.R., Lienhard, G.E., Kahn, C.R. Genes Dev. (2002)
- Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Tamemoto, H., Kadowaki, T., Tobe, K., Yagi, T., Sakura, H., Hayakawa, T., Terauchi, Y., Ueki, K., Kaburagi, Y., Satoh, S. Nature (1994)
- Caspase-mediated Cleavage of Insulin Receptor Substrate. Green, K.A., Naylor, M.J., Lowe, E.T., Wang, P., Marshman, E., Streuli, C.H. J. Biol. Chem. (2004)
- Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin receptor substrate 1. Hennige, A.M., Stefan, N., Kapp, K., Lehmann, R., Weigert, C., Beck, A., Moeschel, K., Mushack, J., Schleicher, E., Häring, H.U. FASEB J. (2006)
- Estradiol stimulates tyrosine phosphorylation of the insulin-like growth factor-1 receptor and insulin receptor substrate-1 in the uterus. Richards, R.G., DiAugustine, R.P., Petrusz, P., Clark, G.C., Sebastian, J. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice. Kushner, J.A., Haj, F.G., Klaman, L.D., Dow, M.A., Kahn, B.B., Neel, B.G., White, M.F. Diabetes (2004)
- The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex. Luo, J., Field, S.J., Lee, J.Y., Engelman, J.A., Cantley, L.C. J. Cell Biol. (2005)
- Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin. Takano, A., Usui, I., Haruta, T., Kawahara, J., Uno, T., Iwata, M., Kobayashi, M. Mol. Cell. Biol. (2001)
- Regulation of upstream binding factor 1 activity by insulin-like growth factor I receptor signaling. Wu, A., Tu, X., Prisco, M., Baserga, R. J. Biol. Chem. (2005)
- Increased insulin sensitivity in IGF-I receptor--deficient brown adipocytes. Mur, C., Valverde, A.M., Kahn, C.R., Benito, M. Diabetes (2002)
- Insulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cells. Borge, P.D., Wolf, B.A. J. Biol. Chem. (2003)
- Effect of receptor phosphorylation on the binding between IRS-1 and IGF-1R as revealed by surface plasmon resonance biosensor. Huang, M., Lai, W.P., Wong, M.S., Yang, M. FEBS Lett. (2001)
- Myosin motor Myo1c and its receptor NEMO/IKK-gamma promote TNF-alpha-induced serine307 phosphorylation of IRS-1. Nakamori, Y., Emoto, M., Fukuda, N., Taguchi, A., Okuya, S., Tajiri, M., Miyagishi, M., Taira, K., Wada, Y., Tanizawa, Y. J. Cell Biol. (2006)
- Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction. Stephens, J.M., Lee, J., Pilch, P.F. J. Biol. Chem. (1997)
- An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Jaeschke, A., Czech, M.P., Davis, R.J. Genes Dev. (2004)
- Impairment of bone healing by insulin receptor substrate-1 deficiency. Shimoaka, T., Kamekura, S., Chikuda, H., Hoshi, K., Chung, U.I., Akune, T., Maruyama, Z., Komori, T., Matsumoto, M., Ogawa, W., Terauchi, Y., Kadowaki, T., Nakamura, K., Kawaguchi, H. J. Biol. Chem. (2004)
- Nuclear translocation of insulin receptor substrate-1 by the insulin receptor in mouse embryo fibroblasts. Wu, A., Sciacca, L., Baserga, R. J. Cell. Physiol. (2003)
- Interruption of growth hormone signaling via SHC and ERK in 3T3-F442A preadipocytes upon knockdown of insulin receptor substrate-1. Wang, X., Yang, N., Deng, L., Li, X., Jiang, J., Gan, Y., Frank, S.J. Mol. Endocrinol. (2009)
- Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis. Valverde, A.M., Kahn, C.R., Benito, M. Diabetes (1999)
- Interleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinases. Yin, T., Keller, S.R., Quelle, F.W., Witthuhn, B.A., Tsang, M.L., Lienhard, G.E., Ihle, J.N., Yang, Y.C. J. Biol. Chem. (1995)
- Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes. He, J., Usui, I., Ishizuka, K., Kanatani, Y., Hiratani, K., Iwata, M., Bukhari, A., Haruta, T., Sasaoka, T., Kobayashi, M. Mol. Endocrinol. (2006)
- Low insulin-like growth factor binding protein-2 expression is responsible for increased insulin receptor substrate-1 phosphorylation in mesangial cells from mice susceptible to glomerulosclerosis. Fornoni, A., Rosenzweig, S.A., Lenz, O., Rivera, A., Striker, G.E., Elliot, S.J. Endocrinology (2006)
- Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase. Drakas, R., Tu, X., Baserga, R. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302. Werner, E.D., Lee, J., Hansen, L., Yuan, M., Shoelson, S.E. J. Biol. Chem. (2004)
- Castration rapidly decreases local insulin-like growth factor-1 levels and inhibits its effects in the ventral prostate in mice. Ohlson, N., Bergh, A., Persson, M.L., Wikstr??m, P. Prostate (2006)