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Xirp1  -  xin actin-binding repeat containing 1

Mus musculus

Synonyms: AI415219, Cardiomyopathy-associated protein 1, Cmya1, Xin, Xin actin-binding repeat-containing protein 1, ...
 
 
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Disease relevance of Cmya1

 

High impact information on Cmya1

 

Biological context of Cmya1

  • Requirement of a novel gene, Xin, in cardiac morphogenesis [9].
  • Both cloned cDNAs have a single open reading frame, encoding proteins with 2,562 and 1,677 amino acids for cXin and mXin, respectively [9].
  • Furthermore, temporal and spatial expressions of Xin in relation to intercalated disc proteins and thin filament proteins suggest roles for Xin in the formation of cell-cell contacts and possibly in myofibrillogenesis [10].
  • Colocalization of Xin with both beta-catenin and N-cadherin is observed throughout embryogenesis and into adulthood [10].
 

Anatomical context of Cmya1

 

Associations of Cmya1 with chemical compounds

  • The overall domain structures of the predicted cXin and mXin proteins, including proline-rich regions, 16 amino acid repeats, DNA-binding domains, SH3-binding motifs and nuclear localization signals, are highly conserved [9].
  • In an attempt to induce in mice the cardiomyopathy associated with daunomycin treatment and to ameliorate this disorder by a protective pretreatment with ICRF-159 (razoxane), young male BDF 1 mice were injected with daunomycin, 6 mg/kg, in multiple doses [11].
 

Other interactions of Cmya1

References

  1. Prevention of cardiomyopathy in mouse models lacking the smooth muscle sarcoglycan-sarcospan complex. Cohn, R.D., Durbeej, M., Moore, S.A., Coral-Vazquez, R., Prouty, S., Campbell, K.P. J. Clin. Invest. (2001) [Pubmed]
  2. Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy. Redfern, C.H., Degtyarev, M.Y., Kwa, A.T., Salomonis, N., Cotte, N., Nanevicz, T., Fidelman, N., Desai, K., Vranizan, K., Lee, E.K., Coward, P., Shah, N., Warrington, J.A., Fishman, G.I., Bernstein, D., Baker, A.J., Conklin, B.R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. The cardiac-specific nuclear delta(B) isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity. Zhang, T., Johnson, E.N., Gu, Y., Morissette, M.R., Sah, V.P., Gigena, M.S., Belke, D.D., Dillmann, W.H., Rogers, T.B., Schulman, H., Ross, J., Brown, J.H. J. Biol. Chem. (2002) [Pubmed]
  4. Quantifying cell death in the myocardium: myosin specific antibody in the evaluation of membrane defects. Haber, E. J. Mol. Cell. Cardiol. (1985) [Pubmed]
  5. Compromised microcirculation in acute murine Trypanosoma cruzi infection. Tanowitz, H.B., Kaul, D.K., Chen, B., Morris, S.A., Factor, S.M., Weiss, L.M., Wittner, M. J. Parasitol. (1996) [Pubmed]
  6. PKC-alpha regulates cardiac contractility and propensity toward heart failure. Braz, J.C., Gregory, K., Pathak, A., Zhao, W., Sahin, B., Klevitsky, R., Kimball, T.F., Lorenz, J.N., Nairn, A.C., Liggett, S.B., Bodi, I., Wang, S., Schwartz, A., Lakatta, E.G., DePaoli-Roach, A.A., Robbins, J., Hewett, T.E., Bibb, J.A., Westfall, M.V., Kranias, E.G., Molkentin, J.D. Nat. Med. (2004) [Pubmed]
  7. Adiponectin-mediated modulation of hypertrophic signals in the heart. Shibata, R., Ouchi, N., Ito, M., Kihara, S., Shiojima, I., Pimentel, D.R., Kumada, M., Sato, K., Schiekofer, S., Ohashi, K., Funahashi, T., Colucci, W.S., Walsh, K. Nat. Med. (2004) [Pubmed]
  8. Distinct functions of junD in cardiac hypertrophy and heart failure. Ricci, R., Eriksson, U., Oudit, G.Y., Eferl, R., Akhmedov, A., Sumara, I., Sumara, G., Kassiri, Z., David, J.P., Bakiri, L., Sasse, B., Idarraga, M.H., Rath, M., Kurz, D., Theussl, H.C., Perriard, J.C., Backx, P., Penninger, J.M., Wagner, E.F. Genes Dev. (2005) [Pubmed]
  9. Requirement of a novel gene, Xin, in cardiac morphogenesis. Wang, D.Z., Reiter, R.S., Lin, J.L., Wang, Q., Williams, H.S., Krob, S.L., Schultheiss, T.M., Evans, S., Lin, J.J. Development (1999) [Pubmed]
  10. Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development. Sinn, H.W., Balsamo, J., Lilien, J., Lin, J.J. Dev. Dyn. (2002) [Pubmed]
  11. Mitigating effects of ICRF-159 (razoxane) on a daunomycin-induced cardiomyopathy in mice. Fischer, V.W., LaRose, L.S., Wang, G.M. Drug and chemical toxicology. (1982) [Pubmed]
  12. Cardiomyopathic features associated with muscular dystrophy are independent of dystrophin absence in cardiovasculature. Hainsey, T.A., Senapati, S., Kuhn, D.E., Rafael, J.A. Neuromuscul. Disord. (2003) [Pubmed]
  13. Overexpression of the serotonin 5-HT2B receptor in heart leads to abnormal mitochondrial function and cardiac hypertrophy. Nebigil, C.G., Jaffré, F., Messaddeq, N., Hickel, P., Monassier, L., Launay, J.M., Maroteaux, L. Circulation (2003) [Pubmed]
  14. Activation of pyk2/related focal adhesion tyrosine kinase and focal adhesion kinase in cardiac remodeling. Melendez, J., Welch, S., Schaefer, E., Moravec, C.S., Avraham, S., Avraham, H., Sussman, M.A. J. Biol. Chem. (2002) [Pubmed]
  15. Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice. Potenza, N., Vecchione, C., Notte, A., De Rienzo, A., Rosica, A., Bauer, L., Affuso, A., De Felice, M., Russo, T., Poulet, R., Cifelli, G., De Vita, G., Lembo, G., Di Lauro, R. EMBO Rep. (2005) [Pubmed]
 
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