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Gene Review

XIRP1  -  xin actin-binding repeat containing 1

Homo sapiens

Synonyms: CMYA1, Cardiomyopathy-associated protein 1, DKFZp451D042, XIN, Xin, ...
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Disease relevance of CMYA1


Psychiatry related information on CMYA1


High impact information on CMYA1


Chemical compound and disease context of CMYA1


Biological context of CMYA1


Anatomical context of CMYA1


Associations of CMYA1 with chemical compounds


Physical interactions of CMYA1


Regulatory relationships of CMYA1

  • These diabetic cardiomyopathy-associated alterations were significantly attenuated (P<0.05) in diabetic transgenic rats expressing the human kallikrein 1 (hKLK1) gene with STZ-induced diabetes [32].

Other interactions of CMYA1


Analytical, diagnostic and therapeutic context of CMYA1


  1. Xin Is a Marker of Skeletal Muscle Damage Severity in Myopathies. Nilsson, M.I., Nissar, A.A., Al-Sajee, D., Tarnopolsky, M.A., Parise, G., Lach, B., Fürst, D.O., van der Ven, P.F., Kley, R.A., Hawke, T.J. Am. J. Pathol. (2013) [Pubmed]
  2. Myocarditis and cardiomyopathy associated with clozapine use in the United States. La Grenade, L., Graham, D., Trontell, A. N. Engl. J. Med. (2001) [Pubmed]
  3. Early antimicrobial treatment of dilated cardiomyopathy associated with Borrelia burgdorferi. Gasser, R., Dusleag, J., Fruhwald, F., Klein, W., Reisinger, E. Lancet (1992) [Pubmed]
  4. Hypertrophic cardiomyopathy associated with hereditary spherocytosis in three generations of one family. Moiseyev, V.S., Korovina, E.A., Polotskaya, E.L., Poliyanskaya, I.S., Yazdovsky, V.V. Lancet (1987) [Pubmed]
  5. Cardiomyopathy associated with the syndrome of amyotrophic chorea and acanthocytosis. Faillace, R.T., Kingston, W.J., Nanda, N.C., Griggs, R.C. Ann. Intern. Med. (1982) [Pubmed]
  6. Cardiomyopathy associated with antiretroviral therapy in patients with HIV infection: a report of six cases. Herskowitz, A., Willoughby, S.B., Baughman, K.L., Schulman, S.P., Bartlett, J.D. Ann. Intern. Med. (1992) [Pubmed]
  7. Marked improvement in left ventricular systolic function 3 months after cessation of excess alcohol intake. Hicks, R.J., Low, R.D., Arkles, L.B. Clinical nuclear medicine. (1993) [Pubmed]
  8. Cardiomyopathy associated with the smoking of crystal methamphetamine. Hong, R., Matsuyama, E., Nur, K. JAMA (1991) [Pubmed]
  9. Reversible cardiomyopathy associated with cocaine intoxication. Chokshi, S.K., Moore, R., Pandian, N.G., Isner, J.M. Ann. Intern. Med. (1989) [Pubmed]
  10. Arrhythmogenic right ventricular dysplasia/cardiomyopathy associated with mutations in the desmosomal gene desmocollin-2. Syrris, P., Ward, D., Evans, A., Asimaki, A., Gandjbakhch, E., Sen-Chowdhry, S., McKenna, W.J. Am. J. Hum. Genet. (2006) [Pubmed]
  11. Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy. Rampazzo, A., Nava, A., Malacrida, S., Beffagna, G., Bauce, B., Rossi, V., Zimbello, R., Simionati, B., Basso, C., Thiene, G., Towbin, J.A., Danieli, G.A. Am. J. Hum. Genet. (2002) [Pubmed]
  12. Dilated cardiomyopathy associated with deficiency of the cytoskeletal protein metavinculin. Maeda, M., Holder, E., Lowes, B., Valent, S., Bies, R.D. Circulation (1997) [Pubmed]
  13. Does treatment influence the natural history of patients with hypertrophic cardiomyopathy? McKenna, W.J. Drugs (1985) [Pubmed]
  14. Hypertrophic cardiomyopathy associated with dexamethasone therapy for bronchopulmonary dysplasia. Werner, J.C., Sicard, R.E., Hansen, T.W., Solomon, E., Cowett, R.M., Oh, W. J. Pediatr. (1992) [Pubmed]
  15. Chelation therapy in cardiovascular disease: ethylenediaminetetraacetic acid, deferoxamine, and dexrazoxane. Elihu, N., Anandasbapathy, S., Frishman, W.H. Journal of clinical pharmacology. (1998) [Pubmed]
  16. Fatal cardiomyopathy associated with pegylated interferon/ribavirin in a patient with chronic hepatitis C. Condat, B., Asselah, T., Zanditenas, D., Estampes, B., Cohen, A., O'Toole, D., Bonnet, J., Ngo, Y., Marcellin, P., Blazquez, M. European journal of gastroenterology & hepatology. (2006) [Pubmed]
  17. Mitochondrial complex I activity is significantly decreased in a patient with maternally inherited type 2 diabetes mellitus and hypertrophic cardiomyopathy associated with mitochondrial DNA C3310T mutation: A cybrid study. Chen, J., Hattori, Y., Nakajima, K., Eizawa, T., Ehara, T., Koyama, M., Hirai, T., Fukuda, Y., Kinoshita, M., Sugiyama, A., Hayashi, J., Onaya, T., Kobayashi, T., Tawata, M. Diabetes Res. Clin. Pract. (2006) [Pubmed]
  18. Xin repeats define a novel actin-binding motif. Pacholsky, D., Vakeel, P., Himmel, M., Löwe, T., Stradal, T., Rottner, K., Fürst, D.O., van der Ven, P.F. J. Cell. Sci. (2004) [Pubmed]
  19. Differences in clinical expression of hypertrophic cardiomyopathy associated with two distinct mutations in the beta-myosin heavy chain gene. A 908Leu----Val mutation and a 403Arg----Gln mutation. Epstein, N.D., Cohn, G.M., Cyran, F., Fananapazir, L. Circulation (1992) [Pubmed]
  20. Familial hypertrophic cardiomyopathy associated with a novel missense mutation affecting the ATP-binding region of the cardiac beta-myosin heavy chain. Bundgaard, H., Havndrup, O., Andersen, P.S., Larsen, L.A., Brandt, N.J., Vuust, J., Kjeldsen, K., Christiansen, M. J. Mol. Cell. Cardiol. (1999) [Pubmed]
  21. A high risk phenotype of hypertrophic cardiomyopathy associated with a compound genotype of two mutated beta-myosin heavy chain genes. Jeschke, B., Uhl, K., Weist, B., Schröder, D., Meitinger, T., Döhlemann, C., Vosberg, H.P. Hum. Genet. (1998) [Pubmed]
  22. External Qi of Yan Xin Qigong differentially regulates the Akt and extracellular signal-regulated kinase pathways and is cytotoxic to cancer cells but not to normal cells. Yan, X., Shen, H., Jiang, H., Zhang, C., Hu, D., Wang, J., Wu, X. Int. J. Biochem. Cell Biol. (2006) [Pubmed]
  23. Beneficial effects of metoprolol in heart failure associated with coronary artery disease: a randomized trial. Fisher, M.L., Gottlieb, S.S., Plotnick, G.D., Greenberg, N.L., Patten, R.D., Bennett, S.K., Hamilton, B.P. J. Am. Coll. Cardiol. (1994) [Pubmed]
  24. Changes at P183 of emerin weaken its protein-protein interactions resulting in X-linked Emery-Dreifuss muscular dystrophy. Ellis, J.A., Yates, J.R., Kendrick-Jones, J., Brown, C.A. Hum. Genet. (1999) [Pubmed]
  25. Expansion of specific alphabeta+ T-cell subsets in the myocardium of patients with myocarditis and idiopathic dilated cardiomyopathy associated with Coxsackievirus B infection. Luppi, P., Rudert, W., Licata, A., Riboni, S., Betters, D., Cotrufo, M., Frati, G., Condorelli, G., Trucco, M. Hum. Immunol. (2003) [Pubmed]
  26. Myomaxin Is a Novel Transcriptional Target of MEF2A That Encodes a Xin-related {alpha}-Actinin-interacting Protein. Huang, H.T., Brand, O.M., Mathew, M., Ignatiou, C., Ewen, E.P., McCalmon, S.A., Naya, F.J. J. Biol. Chem. (2006) [Pubmed]
  27. Cardiac manifestations in disorders of fat and carnitine metabolism in infancy. Ino, T., Sherwood, W.G., Benson, L.N., Wilson, G.J., Freedom, R.M., Rowe, R.D. J. Am. Coll. Cardiol. (1988) [Pubmed]
  28. Xin-repeats and nebulin-like repeats bind to F-actin in a similar manner. Cherepanova, O., Orlova, A., Galkin, V.E., van der Ven, P.F., Fürst, D.O., Jin, J.P., Egelman, E.H. J. Mol. Biol. (2006) [Pubmed]
  29. Use of dexrazoxane and other strategies to prevent cardiomyopathy associated with doxorubicin-taxane combinations. Sparano, J.A. Semin. Oncol. (1998) [Pubmed]
  30. Dilated cardiomyopathy associated with chronic consumption of phendimetrazine. Rostagno, C., Caciolli, S., Felici, M., Gori, F., Neri Serneri, G.G. Am. Heart J. (1996) [Pubmed]
  31. Functional analysis of titin/connectin N2-B mutations found in cardiomyopathy. Matsumoto, Y., Hayashi, T., Inagaki, N., Takahashi, M., Hiroi, S., Nakamura, T., Arimura, T., Nakamura, K., Ashizawa, N., Yasunami, M., Ohe, T., Yano, K., Kimura, A. J. Muscle Res. Cell. Motil. (2005) [Pubmed]
  32. Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction and oxidative stress in experimental diabetic cardiomyopathy. Tschöpe, C., Walther, T., Escher, F., Spillmann, F., Du, J., Altmann, C., Schimke, I., Bader, M., Sanchez-Ferrer, C.F., Schultheiss, H.P., Noutsias, M. FASEB J. (2005) [Pubmed]
  33. A missense mutation in a ubiquitously expressed protein, vinculin, confers susceptibility to hypertrophic cardiomyopathy. Vasile, V.C., Ommen, S.R., Edwards, W.D., Ackerman, M.J. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  34. Clinical and molecular genetic spectrum of autosomal dominant Emery-Dreifuss muscular dystrophy due to mutations of the lamin A/C gene. Bonne, G., Mercuri, E., Muchir, A., Urtizberea, A., Bécane, H.M., Recan, D., Merlini, L., Wehnert, M., Boor, R., Reuner, U., Vorgerd, M., Wicklein, E.M., Eymard, B., Duboc, D., Penisson-Besnier, I., Cuisset, J.M., Ferrer, X., Desguerre, I., Lacombe, D., Bushby, K., Pollitt, C., Toniolo, D., Fardeau, M., Schwartz, K., Muntoni, F. Ann. Neurol. (2000) [Pubmed]
  35. A novel mtDNA point mutation in tRNA(Val) is associated with hypertrophic cardiomyopathy and MELAS. Menotti, F., Brega, A., Diegoli, M., Grasso, M., Modena, M.G., Arbustini, E. Italian heart journal : official journal of the Italian Federation of Cardiology. (2004) [Pubmed]
  36. Clinical features of arrhythmogenic right ventricular dysplasia/cardiomyopathy associated with mutations in plakophilin-2. Dalal, D., Molin, L.H., Piccini, J., Tichnell, C., James, C., Bomma, C., Prakasa, K., Towbin, J.A., Marcus, F.I., Spevak, P.J., Bluemke, D.A., Abraham, T., Russell, S.D., Calkins, H., Judge, D.P. Circulation (2006) [Pubmed]
  37. Echocardiographic-determined septal morphology in Z-disc hypertrophic cardiomyopathy. Theis, J.L., Martijn Bos, J., Bartleson, V.B., Will, M.L., Binder, J., Vatta, M., Towbin, J.A., Gersh, B.J., Ommen, S.R., Ackerman, M.J. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  38. Obesity and idiopathic dilated cardiomyopathy. Coughlin, S.S., Rice, J.C. Epidemiology (Cambridge, Mass.) (1996) [Pubmed]
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