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Gene Review

Tmod1  -  tropomodulin 1

Mus musculus

Synonyms: E-Tmod, Erythrocyte tropomodulin, Tmod, Tropomodulin-1, erythrocyte tropomodulin
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Disease relevance of Tmod1


High impact information on Tmod1


Biological context of Tmod1


Anatomical context of Tmod1


Physical interactions of Tmod1


Regulatory relationships of Tmod1


Other interactions of Tmod1


Analytical, diagnostic and therapeutic context of Tmod1


  1. Pathogenesis of dilated cardiomyopathy: molecular, structural, and population analyses in tropomodulin-overexpressing transgenic mice. Sussman, M.A., Welch, S., Gude, N., Khoury, P.R., Daniels, S.R., Kirkpatrick, D., Walsh, R.A., Price, R.L., Lim, H.W., Molkentin, J.D. Am. J. Pathol. (1999) [Pubmed]
  2. Activation of pyk2/related focal adhesion tyrosine kinase and focal adhesion kinase in cardiac remodeling. Melendez, J., Welch, S., Schaefer, E., Moravec, C.S., Avraham, S., Avraham, H., Sussman, M.A. J. Biol. Chem. (2002) [Pubmed]
  3. Hypertrophic defect unmasked by calcineurin expression in asymptomatic tropomodulin overexpressing transgenic mice. Sussman, M.A., Welch, S., Walker, A., Klevitsky, R., Hewett, T.E., Witt, S.A., Kimball, T.R., Price, R., Lim, H.W., Molkentin, J.D. Cardiovasc. Res. (2000) [Pubmed]
  4. Calcineurin transgenic mice have mitochondrial dysfunction and elevated superoxide production. Sayen, M.R., Gustafsson, A.B., Sussman, M.A., Molkentin, J.D., Gottlieb, R.A. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  5. Prevention of cardiac hypertrophy in mice by calcineurin inhibition. Sussman, M.A., Lim, H.W., Gude, N., Taigen, T., Olson, E.N., Robbins, J., Colbert, M.C., Gualberto, A., Wieczorek, D.F., Molkentin, J.D. Science (1998) [Pubmed]
  6. Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice. Sussman, M.A., Welch, S., Cambon, N., Klevitsky, R., Hewett, T.E., Price, R., Witt, S.A., Kimball, T.R. J. Clin. Invest. (1998) [Pubmed]
  7. Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality. Fritz-Six, K.L., Cox, P.R., Fischer, R.S., Xu, B., Gregorio, C.C., Zoghbi, H.Y., Fowler, V.M. J. Cell Biol. (2003) [Pubmed]
  8. Disruption in the tropomodulin1 (Tmod1) gene compromises cardiomyocyte development in murine embryonic stem cells by arresting myofibril maturation. Ono, Y., Schwach, C., Antin, P.B., Gregorio, C.C. Dev. Biol. (2005) [Pubmed]
  9. The tropomodulin (Tmod) gene maps to chromosome 4, closely linked to Mup1. White, R.A., Dowler, L.L., Woo, M., Adkison, L.R., Pal, S., Gershon, D., Fowler, V.M. Mamm. Genome (1995) [Pubmed]
  10. Cloning of tropomodulin cDNA and localization of gene transcripts during mouse embryogenesis. Ito, M., Swanson, B., Sussman, M.A., Kedes, L., Lyons, G. Dev. Biol. (1995) [Pubmed]
  11. E-Tmod capping of actin filaments at the slow-growing end is required to establish mouse embryonic circulation. Chu, X., Chen, J., Reedy, M.C., Vera, C., Sung, K.L., Sung, L.A. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  12. Cardiac-specific IGF-1 expression attenuates dilated cardiomyopathy in tropomodulin-overexpressing transgenic mice. Welch, S., Plank, D., Witt, S., Glascock, B., Schaefer, E., Chimenti, S., Andreoli, A.M., Limana, F., Leri, A., Kajstura, J., Anversa, P., Sussman, M.A. Circ. Res. (2002) [Pubmed]
  13. Genomic organization of mouse and human erythrocyte tropomodulin genes encoding the pointed end capping protein for the actin filaments. Chu, X., Thompson, D., Yee, L.J., Sung, L.A. Gene (2000) [Pubmed]
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