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Gene Review

FGL1  -  fibrinogen-like 1

Homo sapiens

Synonyms: Fibrinogen-like protein 1, HFREP-1, HFREP1, HP-041, Hepassocin, ...
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Disease relevance of FGL1


High impact information on FGL1

  • The ficolin 1, 2 and 3 (derived from the FCN1, 2 and 3 genes, respectively) are homologous soluble pattern recognition molecules of importance for innate immunity, comprising collagen-like and fibrinogen-like domains, binding to sugar groups on different types of microorganisms [3].
  • FCN2 promoter polymorphisms were associated with marked changes in the Ficolin-2 serum concentration, whereas two polymorphisms clustered in the exon encoding the fibrinogen-like domain were associated with increased and decreased GlcNAc binding, respectively [3].
  • Genes that were overexpressed in NASH included complement component C3 and hepatocyte-derived fibrinogen-related protein, potentially contributing to impaired insulin sensitivity [4].
  • A truncated monomeric Ang1 variant (i.e. DeltaAng1) containing the isolated fibrinogen-like receptor-binding domain of Ang1 was created and recombinantly produced in insect cells [5].
  • These data demonstrate that the epididymis possesses a specific mechanism to identify and envelop defective spermatozoa with a protein complex containing the fibrinogen-like protein fgl2 [6].

Biological context of FGL1


Anatomical context of FGL1


Associations of FGL1 with chemical compounds


Other interactions of FGL1

  • We previously cloned a novel human lectin, designated P35, with both collagen-like and fibrinogen-like domains [18].
  • Significant downregulations of FGG, FGL1 and SERPINF2 were also suggested in 30, 23 and 33% of cases, respectively, compared to their nonmalignant counterparts (P<0.016) [19].
  • LFIRE-1/HFREP-1, a liver-specific gene, is frequently downregulated and has growth suppressor activity in hepatocellular carcinoma [8].
  • The mutagenesis study indicated the domain that is responsible for the ECM association of Ang-1 is the linker peptide region between the coiled-coil and the fibrinogen-like domains [20].
  • The vascular walls undergoing fibrinoid necrosis did not show any beta/A4 or cystatin C but presented with fibrinogen-like immunoreactivities, indicating invasion of plasma components [21].

Analytical, diagnostic and therapeutic context of FGL1


  1. Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1. Yamamoto, T., Gotoh, M., Sasaki, H., Terada, M., Kitajima, M., Hirohashi, S. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  2. Specific expression and regulation of hepassocin in the liver and down-regulation of the correlation of HNF1alpha with decreased levels of hepassocin in human hepatocellular carcinoma. Yu, H.T., Yu, M., Li, C.Y., Zhan, Y.Q., Xu, W.X., Li, Y.H., Li, W., Wang, Z.D., Ge, C.H., Yang, X.M. J. Biol. Chem. (2009) [Pubmed]
  3. Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2. Hummelshoj, T., Munthe-Fog, L., Madsen, H.O., Fujita, T., Matsushita, M., Garred, P. Hum. Mol. Genet. (2005) [Pubmed]
  4. Hepatic gene expression in histologically progressive nonalcoholic steatohepatitis. Sreekumar, R., Rosado, B., Rasmussen, D., Charlton, M. Hepatology (2003) [Pubmed]
  5. Effects of protein and gene transfer of the angiopoietin-1 fibrinogen-like receptor-binding domain on endothelial and vessel organization. Weber, C.C., Cai, H., Ehrbar, M., Kubota, H., Martiny-Baron, G., Weber, W., Djonov, V., Weber, E., Mallik, A.S., Fussenegger, M., Frei, K., Hubbell, J.A., Zisch, A.H. J. Biol. Chem. (2005) [Pubmed]
  6. Region-specific expression and secretion of the fibrinogen-related protein, fgl2, by epithelial cells of the hamster epididymis and its role in disposal of defective spermatozoa. Olson, G.E., Winfrey, V.P., NagDas, S.K., Melner, M.H. J. Biol. Chem. (2004) [Pubmed]
  7. Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains. Ichijo, H., Hellman, U., Wernstedt, C., Gonez, L.J., Claesson-Welsh, L., Heldin, C.H., Miyazono, K. J. Biol. Chem. (1993) [Pubmed]
  8. LFIRE-1/HFREP-1, a liver-specific gene, is frequently downregulated and has growth suppressor activity in hepatocellular carcinoma. Yan, J., Yu, Y., Wang, N., Chang, Y., Ying, H., Liu, W., He, J., Li, S., Jiang, W., Li, Y., Liu, H., Wang, H., Xu, Y. Oncogene (2004) [Pubmed]
  9. Molecular cloning and functional expression analysis of a cDNA for human hepassocin, a liver-specific protein with hepatocyte mitogenic activity. Hara, H., Yoshimura, H., Uchida, S., Toyoda, Y., Aoki, M., Sakai, Y., Morimoto, S., Shiokawa, K. Biochim. Biophys. Acta (2001) [Pubmed]
  10. Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes. Marazzi, S., Blum, S., Hartmann, R., Gundersen, D., Schreyer, M., Argraves, S., von Fliedner, V., Pytela, R., Rüegg, C. J. Immunol. (1998) [Pubmed]
  11. Coagulation in the crayfish, Astacus leptodactylus: attempts to identify a fibrinogen-like factor in the hemolymph. Durliat, M., Vranckx, R. Biol. Bull. (1976) [Pubmed]
  12. Fibrinogen-like substance and thrombin-like enzyme in seminal plasma: coagulation system of human semen. Park, J.Y., Yoshimura, Y., Nozawa, S., Umeda, T., Akihama, S., Matsuda, Y. Arch. Androl. (1997) [Pubmed]
  13. High-resolution NMR studies of fibrinogen-like peptides in solution: interaction of thrombin with residues 1-23 of the A alpha chain of human fibrinogen. Ni, F., Konishi, Y., Frazier, R.B., Scheraga, H.A., Lord, S.T. Biochemistry (1989) [Pubmed]
  14. Nuclear magnetic resonance study of fibrinogen-like peptides and their structure in dimethyl sulfoxide and water. von Dreele, P.H., Rae, I.D., Scheraga, H.A. Biochemistry (1978) [Pubmed]
  15. Binding of a fibrinogen mimetic stabilizes integrin alphaIIbbeta3's open conformation. Hantgan, R.R., Rocco, M., Nagaswami, C., Weisel, J.W. Protein Sci. (2001) [Pubmed]
  16. The role of ficolins in innate immunity. Matsushita, M., Fujita, T. Immunobiology (2002) [Pubmed]
  17. Serum concentration of Hakata antigen, a member of the ficolins, is linked with inhibition of Aerococcus viridans growth. Tsujimura, M., Miyazaki, T., Kojima, E., Sagara, Y., Shiraki, H., Okochi, K., Maeda, Y. Clin. Chim. Acta (2002) [Pubmed]
  18. Cloning and characterization of the human lectin P35 gene and its related gene. Endo, Y., Sato, Y., Matsushita, M., Fujita, T. Genomics (1996) [Pubmed]
  19. Positional expression profiling indicates candidate genes in deletion hotspots of hepatocellular carcinoma. Chan, K.Y., Lai, P.B., Squire, J.A., Beheshti, B., Wong, N.L., Sy, S.M., Wong, N. Mod. Pathol. (2006) [Pubmed]
  20. Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region. Xu, Y., Yu, Q. J. Biol. Chem. (2001) [Pubmed]
  21. Computer-assisted three-dimensional image analysis of cerebral amyloid angiopathy. Maeda, A., Yamada, M., Itoh, Y., Otomo, E., Hayakawa, M., Miyatake, T. Stroke (1993) [Pubmed]
  22. A (1-->3)-beta-D-glucan recognition protein from the sponge Suberites domuncula. Mediated activation of fibrinogen-like protein and epidermal growth factor gene expression. Perović-Ottstadt, S., Adell, T., Proksch, P., Wiens, M., Korzhev, M., Gamulin, V., Müller, I.M., Müller, W.E. Eur. J. Biochem. (2004) [Pubmed]
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