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Gene Review

Fgfr2  -  fibroblast growth factor receptor 2

Rattus norvegicus

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Disease relevance of Fgfr2


High impact information on Fgfr2


Biological context of Fgfr2


Anatomical context of Fgfr2


Other interactions of Fgfr2

  • This is in addition to the irreversible loss by splice switching of the FGFR2 ectodomain that abrogates response to FGF-7 and homologues from the stroma [8].

Analytical, diagnostic and therapeutic context of Fgfr2

  • Immunoprecipitation of FGFR2 led to coprecipitation of alpha 1D Ca(2+) channel subunits and precipitation of alpha 1D subunits led to coprecipitation of FGFR2 [6].
  • The signaling cascade of FGFR2 was studied using the perforated patch configuration of the patch-clamp technique in cultured rat retinal pigment epithelial (RPE) cells that express both FGFR1 and FGFR2 [6].


  1. An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing. Carstens, R.P., McKeehan, W.L., Garcia-Blanco, M.A. Mol. Cell. Biol. (1998) [Pubmed]
  2. Aberrant fibroblast growth factor receptor 2 signalling in esophageal atresia with tracheoesophageal fistula. Spilde, T.L., Bhatia, A.M., Mehta, S.S., Hembree, M.J., Preuett, B.L., Ostlie, D.J., Prasadan, K., Li, Z., Snyder, C.L., Gittes, G.K. J. Pediatr. Surg. (2004) [Pubmed]
  3. A novel intronic cis element, ISE/ISS-3, regulates rat fibroblast growth factor receptor 2 splicing through activation of an upstream exon and repression of a downstream exon containing a noncanonical branch point sequence. Hovhannisyan, R.H., Carstens, R.P. Mol. Cell. Biol. (2005) [Pubmed]
  4. A stem structure in fibroblast growth factor receptor 2 transcripts mediates cell-type-specific splicing by approximating intronic control elements. Baraniak, A.P., Lasda, E.L., Wagner, E.J., Garcia-Blanco, M.A. Mol. Cell. Biol. (2003) [Pubmed]
  5. An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein. Carstens, R.P., Wagner, E.J., Garcia-Blanco, M.A. Mol. Cell. Biol. (2000) [Pubmed]
  6. Fibroblast growth factor receptor 2 (FGFR2) in brain neurons and retinal pigment epithelial cells act via stimulation of neuroendocrine L-type channels (Ca(v)1.3). Rosenthal, R., Thieme, H., Strauss, O. FASEB J. (2001) [Pubmed]
  7. Age-related changes in levels of tyrosine kinase B receptor and fibroblast growth factor receptor 2 in the rat inferior colliculus: implications for neural senescence. Sato, T., Wilson, T.S., Hughes, L.F., Konrad, H.R., Nakayama, M., Helfert, R.H. Neuroscience (2001) [Pubmed]
  8. Fibroblast growth factor receptor 2 limits and receptor 1 accelerates tumorigenicity of prostate epithelial cells. Feng, S., Wang, F., Matsubara, A., Kan, M., McKeehan, W.L. Cancer Res. (1997) [Pubmed]
  9. Proliferation of neointimal smooth muscle cells after arterial injury. Dependence on interactions between fibroblast growth factor receptor-2 and fibroblast growth factor-9. Agrotis, A., Kanellakis, P., Kostolias, G., Di Vitto, G., Wei, C., Hannan, R., Jennings, G., Bobik, A. J. Biol. Chem. (2004) [Pubmed]
  10. Rat oligodendrocytes and astrocytes preferentially express fibroblast growth factor receptor-2 and -3 mRNAs. Miyake, A., Hattori, Y., Ohta, M., Itoh, N. J. Neurosci. Res. (1996) [Pubmed]
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