Gene Review:
Fgfr2 - fibroblast growth factor receptor 2
Mus musculus
Synonyms:
AU043015, AW556123, Bek, Ect1, FGFR-2, ...
Mansukhani,
Ambrosetti,
Holmes,
Cornivelli,
Basilico,
Kettunen,
Karavanova,
Thesleff,
Wei,
Zhan,
Liu,
Chang,
Haldankar,
Burkhardt,
Crouse,
Hui,
Juan,
Talvenheimo,
Kim,
Li,
Boone,
Borges,
Perlyn,
Morriss-Kay,
Darvann,
Tenenbaum,
Ornitz,
- Development of the mammalian urethra is controlled by Fgfr2-IIIb. Petiot, A., Perriton, C.L., Dickson, C., Cohn, M.J. Development (2005)
- Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers. Jang, J.H., Shin, K.H., Park, J.G. Cancer Res. (2001)
- Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Yu, K., Xu, J., Liu, Z., Sosic, D., Shao, J., Olson, E.N., Towler, D.A., Ornitz, D.M. Development (2003)
- Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome. Yu, K., Herr, A.B., Waksman, G., Ornitz, D.M. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain. Olsen, S.K., Li, J.Y., Bromleigh, C., Eliseenkova, A.V., Ibrahimi, O.A., Lao, Z., Zhang, F., Linhardt, R.J., Joyner, A.L., Mohammadi, M. Genes Dev. (2006)
- Stomach development is dependent on fibroblast growth factor 10/fibroblast growth factor receptor 2b-mediated signaling. Spencer-Dene, B., Sala, F.G., Bellusci, S., Gschmeissner, S., Stamp, G., Dickson, C. Gastroenterology (2006)
- Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation. Mansukhani, A., Ambrosetti, D., Holmes, G., Cornivelli, L., Basilico, C. J. Cell Biol. (2005)
- Inhibition of fibroblast growth factor/fibroblast growth factor receptor activity in glioma cells impedes tumor growth by both angiogenesis-dependent and -independent mechanisms. Auguste, P., Gürsel, D.B., Lemière, S., Reimers, D., Cuevas, P., Carceller, F., Di Santo, J.P., Bikfalvi, A. Cancer Res. (2001)
- Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer. Carstens, R.P., Eaton, J.V., Krigman, H.R., Walther, P.J., Garcia-Blanco, M.A. Oncogene (1997)
- Mutation associated with Crouzon syndrome causes ligand-independent dimerization and activation of FGF receptor-2. Mangasarian, K., Li, Y., Mansukhani, A., Basilico, C. J. Cell. Physiol. (1997)
- Link between reduced nephron number and hypertension: studies in a mutant mouse model. Poladia, D.P., Kish, K., Kutay, B., Bauer, J., Baum, M., Bates, C.M. Pediatr. Res. (2006)
- The mouse seminal vesicle shape mutation is allelic with Fgfr2. Kuslak, S.L., Thielen, J.L., Marker, P.C. Development (2007)
- Fgfr1 and Fgfr2 have distinct differentiation- and proliferation-related roles in the developing mouse skull vault. Iseki, S., Wilkie, A.O., Morriss-Kay, G.M. Development (1999)
- Loss of Fgfr3 leads to excess hair cell development in the mouse organ of Corti. Hayashi, T., Cunningham, D., Bermingham-McDonogh, O. Dev. Dyn. (2007)
- Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis. Lin, Y., Liu, G., Zhang, Y., Hu, Y.P., Yu, K., Lin, C., McKeehan, K., Xuan, J.W., Ornitz, D.M., Shen, M.M., Greenberg, N., McKeehan, W.L., Wang, F. Development (2007)
- Novel roles of Fgfr2 in AER differentiation and positioning of the dorsoventral limb interface. Gorivodsky, M., Lonai, P. Development (2003)
- Mapping of murine fibroblast growth factor receptors refines regions of homology between mouse and human chromosomes. Avraham, K.B., Givol, D., Avivi, A., Yayon, A., Copeland, N.G., Jenkins, N.A. Genomics (1994)
- Genetic control of the cell proliferation-differentiation balance in the developing skull vault: roles of fibroblast growth factor receptor signalling pathways. Morriss-Kay, G.M., Iseki, S., Johnson, D. Novartis Found. Symp. (2001)
- Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Xu, X., Weinstein, M., Li, C., Naski, M., Cohen, R.I., Ornitz, D.M., Leder, P., Deng, C. Development (1998)
- A model for the pharmacological treatment of crouzon syndrome. Perlyn, C.A., Morriss-Kay, G., Darvann, T., Tenenbaum, M., Ornitz, D.M. Neurosurgery (2006)
- Identification of fibroblast growth factor 9 (FGF9) as a high affinity, heparin dependent ligand for FGF receptors 3 and 2 but not for FGF receptors 1 and 4. Hecht, D., Zimmerman, N., Bedford, M., Avivi, A., Yayon, A. Growth Factors (1995)
- Induction of urothelial cell proliferation by fibroblast growth factor-7 in RAG1-deficient mice. Bassuk, J.A., Cochrane, K., Mitchell, M.E. Adv. Exp. Med. Biol. (2003)
- Responsiveness of developing dental tissues to fibroblast growth factors: expression of splicing alternatives of FGFR1, -2, -3, and of FGFR4; and stimulation of cell proliferation by FGF-2, -4, -8, and -9. Kettunen, P., Karavanova, I., Thesleff, I. Dev. Genet. (1998)
- MINT, the Msx2 interacting nuclear matrix target, enhances Runx2-dependent activation of the osteocalcin fibroblast growth factor response element. Sierra, O.L., Cheng, S.L., Loewy, A.P., Charlton-Kachigian, N., Towler, D.A. J. Biol. Chem. (2004)
- FGF3 attached to a phosholipid membrane anchor gains a high transforming capacity. Implications of microdomains for FGF3 cell transformation. Köhl, R., Antoine, M., Reimers, K., Kiefer, P. J. Biol. Chem. (2002)
- Regulation of FGF receptor-2 expression by transcription factor E2F-1. Tashiro, E., Minato, Y., Maruki, H., Asagiri, M., Imoto, M. Oncogene (2003)
- Multiple structural elements determine ligand binding of fibroblast growth factor receptors. Evidence that both Ig domain 2 and 3 define receptor specificity. Zimmer, Y., Givol, D., Yayon, A. J. Biol. Chem. (1993)
- Ribosomal S6 kinase as a mediator of keratinocyte growth factor-induced activation of Akt in epithelial cells. Pan, Z.Z., Devaux, Y., Ray, P. Mol. Biol. Cell (2004)
- Growth inhibition by keratinocyte growth factor receptor of human salivary adenocarcinoma cells through induction of differentiation and apoptosis. Zhang, Y., Wang, H., Toratani, S., Sato, J.D., Kan, M., McKeehan, W.L., Okamoto, T. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Differential expression of fibroblast growth factor receptors 1 to 4 and ligand genes in late fetal and early postnatal rat lung. Powell, P.P., Wang, C.C., Horinouchi, H., Shepherd, K., Jacobson, M., Lipson, M., Jones, R. Am. J. Respir. Cell Mol. Biol. (1998)
- Generation and characterization of monoclonal antibodies to human keratinocyte growth factor receptor. Wei, P., Zhan, J., Liu, S., Chang, D., Haldankar, R., Burkhardt, K., Crouse, J., Hui, J., Juan, T., Talvenheimo, J., Kim, H., Li, L., Boone, T., Borges, L. Hybridoma (2005) (2006)