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Id1  -  inhibitor of DNA binding 1

Rattus norvegicus

Synonyms: DNA-binding protein inhibitor ID-1, ID125A, Id-1, Idb1, Inhibitor of DNA binding 1, ...
 
 
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Disease relevance of Id1

  • The association of Id-1, MIF and GSTpi with acquired drug resistance in hormone independent prostate cancer cells [1].
  • We have constructed a recombinant adenovirus (Ad.Id1) that allows for efficient expression of the helix-loop-helix protein Id1 [2].
  • Overexpression of a dominant negative HLH protein, Id-1, decreased the activity of the 1.1-kb osteocalcin gene promoter cotransfected into rat osteoblastic osteosarcoma ROS17/2.8 cells [3].
  • Furthermore, expression of Id-1 appeared to be stronger in poorly differentiated lesions than in well-differentiated carcinomas, suggesting that the levels of Id-1 expression may be correlated with the malignancy of tumors [4].
  • Quantification of MyoD, myogenin, MRF4 and Id-1 by reverse-transcriptase polymerase chain reaction in rat muscles--effects of hypothyroidism and chronic low-frequency stimulation [5].
 

Psychiatry related information on Id1

  • An inverse relationship between Id1/3 and myelin P0 expression was consistent with a role for these two Id proteins as inhibitors of differentiation, and Id1/3 proteins strongly repressed myelin gene promoter activity [6].
 

High impact information on Id1

  • Addition of exogeneous Id1 protein, a negative regulator of basic HLH proteins, disrupted specific complexes formed by PC12 cell nuclear extracts on a CANNTG consensus oligonucleotide [7].
  • In vivo, Id1 expression and Smad1 phosphorylation were co-induced during fibrogenesis [8].
  • In conclusion, Id1 is identified as TGF-beta/ALK1/Smad1 target gene in HSCs and represents a critical mediator of transdifferentiation that might be involved in hepatic fibrogenesis [8].
  • In an attempt to elucidate TGF-beta target genes responsible for fibrogenesis, an analysis of Smad7-dependent mRNA expression profiles in HSCs was performed, resulting in the identification of the inhibitor of differentiation 1 (Id1) gene [8].
  • Expression of helix-loop-helix factor Id-1 is dependent on the hepatocyte proliferation and differentiation status in rat liver and in primary culture [9].
 

Biological context of Id1

 

Anatomical context of Id1

 

Associations of Id1 with chemical compounds

  • The cytotoxity assay results demonstrated that cells overexpressing the Id-1 gene increased in their resistance to doxorubicin, paclitaxel and cyclophosphamide [1].
  • The DNA methyltransferase inhibitor 5-azacytidine specifically alters the expression of helix-loop-helix proteins Id1, Id2 and Id3 during neuronal differentiation [14].
  • Treatment of Id-1 expressing cells with p38MAPK and JNK inhibitors resulted in decreased doxorubicin induced apoptosis [15].
  • In the normal kidney strong immunostaining for Id-1 was found in the distal nephron, especially in the distal convoluted tubule in the cortex [16].
 

Other interactions of Id1

  • In contrast to Id1 and Id2, which do not form homodimers, the carboxyl-terminal sequence of this alternatively spliced Id1 transcript, termed Id1.25, permits homodimerization [10].
  • We have recently identified the adult rat pineal gland as a major site of Id-1 and Id-3 expression [12].
 

Analytical, diagnostic and therapeutic context of Id1

References

  1. The association of Id-1, MIF and GSTpi with acquired drug resistance in hormone independent prostate cancer cells. Lin, J.C., Chang, S.Y., Hsieh, D.S., Lee, C.F., Yu, D.S. Oncol. Rep. (2005) [Pubmed]
  2. Expression of Id1 results in apoptosis of cardiac myocytes through a redox-dependent mechanism. Tanaka, K., Pracyk, J.B., Takeda, K., Yu, Z.X., Ferrans, V.J., Deshpande, S.S., Ozaki, M., Hwang, P.M., Lowenstein, C.J., Irani, K., Finkel, T. J. Biol. Chem. (1998) [Pubmed]
  3. Identification of a DNA sequence involved in osteoblast-specific gene expression via interaction with helix-loop-helix (HLH)-type transcription factors. Tamura, M., Noda, M. J. Cell Biol. (1994) [Pubmed]
  4. Up-regulation of TRPM-2, MMP-7 and ID-1 during sex hormone-induced prostate carcinogenesis in the Noble rat. Ouyang, X.S., Wang, X., Lee, D.T., Tsao, S.W., Wong, Y.C. Carcinogenesis (2001) [Pubmed]
  5. Quantification of MyoD, myogenin, MRF4 and Id-1 by reverse-transcriptase polymerase chain reaction in rat muscles--effects of hypothyroidism and chronic low-frequency stimulation. Kraus, B., Pette, D. Eur. J. Biochem. (1997) [Pubmed]
  6. Reciprocal Id expression and myelin gene regulation in Schwann cells. Thatikunta, P., Qin, W., Christy, B.A., Tennekoon, G.I., Rutkowski, J.L. Mol. Cell. Neurosci. (1999) [Pubmed]
  7. Regulation of Id1 and its association with basic helix-loop-helix proteins during nerve growth factor-induced differentiation of PC12 cells. Einarson, M.B., Chao, M.V. Mol. Cell. Biol. (1995) [Pubmed]
  8. Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells. Wiercinska, E., Wickert, L., Denecke, B., Said, H.M., Hamzavi, J., Gressner, A.M., Thorikay, M., ten Dijke, P., Mertens, P.R., Breitkopf, K., Dooley, S. Hepatology (2006) [Pubmed]
  9. Expression of helix-loop-helix factor Id-1 is dependent on the hepatocyte proliferation and differentiation status in rat liver and in primary culture. Le Jossic, C., Ilyin, G.P., Loyer, P., Glaise, D., Cariou, S., Guguen-Guillouzo, C. Cancer Res. (1994) [Pubmed]
  10. Posttranscriptional regulation of Id1 activity in cardiac muscle. Alternative splicing of novel Id1 transcript permits homodimerization. Springhorn, J.P., Singh, K., Kelly, R.A., Smith, T.W. J. Biol. Chem. (1994) [Pubmed]
  11. Reprogramming the cell cycle for endoreduplication in rodent trophoblast cells. MacAuley, A., Cross, J.C., Werb, Z. Mol. Biol. Cell (1998) [Pubmed]
  12. Id-1 expression defines a subset of vimentin/S-100beta-positive, GFAP-negative astrocytes in the adult rat pineal gland. Kofler, B., Bulleyment, A., Humphries, A., Carter, D.A. Histochem. J. (2002) [Pubmed]
  13. Expression and functional role of the Id HLH family in cultured astrocytes. Tzeng, S.F., de Vellis, J. Brain Res. Mol. Brain Res. (1997) [Pubmed]
  14. The DNA methyltransferase inhibitor 5-azacytidine specifically alters the expression of helix-loop-helix proteins Id1, Id2 and Id3 during neuronal differentiation. Persengiev, S.P., Kilpatrick, D.L. Neuroreport (1997) [Pubmed]
  15. Modulation of mitogen-activated protein kinase cascades by differentiation-1 protein: acquired drug resistance of hormone independent prostate cancer cells. Lin, J.C., Chang, S.Y., Hsieh, D.S., Lee, C.F., Yu, D.S. J. Urol. (2005) [Pubmed]
  16. Expression of Id-1 mRNA and protein in the post-ischemic regenerating rat kidney. Matejka, G.L., Thornemo, M., Kernholt, A., Lindahl, A. Exp. Nephrol. (1998) [Pubmed]
  17. Denervation stimulates apoptosis but not Id2 expression in hindlimb muscles of aged rats. Alway, S.E., Degens, H., Krishnamurthy, G., Chaudhrai, A. J. Gerontol. A Biol. Sci. Med. Sci. (2003) [Pubmed]
  18. Regulation of E-box DNA binding during in vivo and in vitro activation of rat and human hepatic stellate cells. Vincent, K.J., Jones, E., Arthur, M.J., Smart, D.E., Trim, J., Wright, M.C., Mann, D.A. Gut (2001) [Pubmed]
 
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