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Gene Review

fimA  -  fimbrilin

Porphyromonas gingivalis W83

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Disease relevance of fimA


High impact information on fimA


Chemical compound and disease context of fimA


Biological context of fimA


Anatomical context of fimA

  • However, adherence to and invasion of KB cells was not detected with the P. gingivalis fimA mutants, DPG3 and MPG1 [13].
  • Adhesion to and invasion of epithelial cells by the periodontopathogen Porphyromonas gingivalis is promoted by the major fimbriae, encoded by fimA [14].
  • Fimbria encoded by the gene fimA is considered one of the main factors in the colonization of the oral cavity by Porphyromonas gingivalis [15].
  • Several studies have provided clinical evidence that FimA clonal variation may contribute to the periodontopathogenicity of Porphyromonas gingivalis (P.g.). We studied the gene expression profiling of the macrophage-like human cell line U937 after infection of two types of P.g. (fimA type I; Pg-I and fimA type II; Pg-II) using microarray [16].
  • Specific binding region within fimbrial subunit protein (fimbrilin) from Porphyromonas gingivalis strain 381 was studied in cultured human gingival fibroblasts [17].

Associations of fimA with chemical compounds

  • Insert DNA from the recombinant clones did not contain homology to the P. gingivalis fimA gene, encoding fimbrillin, the subunit protein of fimbriae, but showed various degrees of homology to certain cysteine protease-hemagglutinin genes [18].
  • Type II fimA organisms caused the most significant induction of serum sialic acid, as well as other infectious symptoms, followed by types Ib, IV and V [19].
  • Heating for 5 min at 100 degrees C in sodium dodecyl sulfate was necessary to denature the fimbriae into their constituent protein (fimbrilin) monomers with a reduced content of beta-sheet structure [20].

Other interactions of fimA

  • Conclusion: Infection of P. gingivalis with prtC+/fimA+ and A. actinomycetemcomitans with lktA+ correlates with periodontal destruction of CP in Chinese. Nonetheless P. gingivalis fimA, prtC genes and A. actinomycetemcomitans lktA gene are closely associated with periodontal destruction, while A. actinomycetemcomitans fap gene is not [21].
  • This property was dependent, in part, on the strain 381 fimA, ppk, and usp genes [22].
  • Both the arginine-specific cysteine proteinase (Arg-gingipain) and lysine-specific cysteine proteinase (Lys-gingipain) activity of the P. gingivalis fimA type I strain were significantly higher than those of the fimA type II strains [23].

Analytical, diagnostic and therapeutic context of fimA

  • Expression of fimbriae on the surface of the fimA mutant and the wild-type strain, ATCC 33277, were investigated by electron microscopy [24].
  • We previously examined the distribution of P. gingivalis in terms of fimA genotypes in periodontitis patients using a fimA type-specific PCR assay [3].
  • CONCLUSIONS: BOP in initially type I positive sites showed little improvement with treatment, and the combined persistence of fimA type I and T. forsythensis seemed to be involved in this poor treatment outcome [25].
  • Moreover, 26 P. gingivalis isolates were analysed by sequence analysis of the fimA gene [26].
  • The present study demonstrated the potential of P. gingivalis fimA type I as a predictor of persistent BOP after treatment [25].


  1. Regulation of the Porphyromonas gingivalis fimA (Fimbrillin) gene. Xie, H., Chung, W.O., Park, Y., Lamont, R.J. Infect. Immun. (2000) [Pubmed]
  2. Functional differences among FimA variants of Porphyromonas gingivalis and their effects on adhesion to and invasion of human epithelial cells. Nakagawa, I., Amano, A., Kuboniwa, M., Nakamura, T., Kawabata, S., Hamada, S. Infect. Immun. (2002) [Pubmed]
  3. Distribution and molecular characterization of Porphyromonas gingivalis carrying a new type of fimA gene. Nakagawa, I., Amano, A., Kimura, R.K., Nakamura, T., Kawabata, S., Hamada, S. J. Clin. Microbiol. (2000) [Pubmed]
  4. Distribution of Porphyromonas gingivalis fimA genotypes in Japanese children and adolescents. Tamura, K., Nakano, K., Nomura, R., Miyake, S., Nakagawa, I., Amano, A., Ooshima, T. J. Periodontol. (2005) [Pubmed]
  5. Multiple restriction fragment length polymorphism genotypes of Porphyromonas gingivalis in single periodontal pockets. Zhang, Y.J., Yasui, S., Yoshimura, F., Ishikawa, I. Oral Microbiol. Immunol. (1995) [Pubmed]
  6. A regulation cascade controls expression of Porphyromonas gingivalis fimbriae via the FimR response regulator. Nishikawa, K., Yoshimura, F., Duncan, M.J. Mol. Microbiol. (2004) [Pubmed]
  7. Targeted salivary gland immunization with plasmid DNA elicits specific salivary immunoglobulin A and G antibodies and serum immunoglobulin G antibodies in mice. Kawabata, S., Terao, Y., Fujiwara, T., Nakagawa, I., Hamada, S. Infect. Immun. (1999) [Pubmed]
  8. Relationship of periodontal bacteria and Porphyromonas gingivalis fimA variations with phenytoin-induced gingival overgrowth. Akiyama, S., Amano, A., Kato, T., Takada, Y., Kimura, K.R., Morisaki, I. Oral diseases. (2006) [Pubmed]
  9. Inconsistency between the fimbrilin gene and the antigenicity of lipopolysaccharides in selected strains of Porphyromonas gingivalis. Fujiwara, T., Nakagawa, I., Morishima, S., Takahashi, I., Hamada, S. FEMS Microbiol. Lett. (1994) [Pubmed]
  10. Restriction fragment length polymorphism analysis of the fimbrillin locus, fimA, of Porphyromonas gingivalis. Loos, B.G., Dyer, D.W. J. Dent. Res. (1992) [Pubmed]
  11. Inactivation of the Porphyromonas gingivalis fimA gene blocks periodontal damage in gnotobiotic rats. Malek, R., Fisher, J.G., Caleca, A., Stinson, M., van Oss, C.J., Lee, J.Y., Cho, M.I., Genco, R.J., Evans, R.T., Dyer, D.W. J. Bacteriol. (1994) [Pubmed]
  12. Enumeration of Porphyromonas gingivalis, Prevotella intermedia and Actinobacillus actinomycetemcomitans in subgingival plaque samples by a quantitative-competitive PCR method. Doungudomdacha, S., Rawlinson, A., Douglas, C.W. J. Med. Microbiol. (2000) [Pubmed]
  13. A role for fimbriae in Porphyromonas gingivalis invasion of oral epithelial cells. Njoroge, T., Genco, R.J., Sojar, H.T., Hamada, N., Genco, C.A. Infect. Immun. (1997) [Pubmed]
  14. Adhesion and invasion to epithelial cells by fimA genotypes of Porphyromonas gingivalis. Umeda, J.E., Missailidis, C., Longo, P.L., Anzai, D., Wikstr??m, M., Mayer, M.P. Oral Microbiol. Immunol. (2006) [Pubmed]
  15. Distribution of fimA genotypes of Porphyromonas gingivalis in subjects with various periodontal conditions. Missailidis, C.G., Umeda, J.E., Ota-Tsuzuki, C., Anzai, D., Mayer, M.P. Oral Microbiol. Immunol. (2004) [Pubmed]
  16. Differential gene induction in macrophage-like human cells by two types of Porphyromonas gingivalis: a microarray study. Oshikawa, M., Sugano, N., Koshi, R., Ikeda, K., Ito, K. Journal of oral science. (2004) [Pubmed]
  17. Antagonistic effect of synthetic peptides corresponding to the binding regions within fimbrial subunit protein from Porphyromonas gingivalis to human gingival fibroblasts. Ogawa, T., Ogo, H., Kinoshita, A. Vaccine (1997) [Pubmed]
  18. Porphyromonas gingivalis genes isolated by screening for epithelial cell attachment. Duncan, M.J., Emory, S.A., Almira, E.C. Infect. Immun. (1996) [Pubmed]
  19. Comparison of inflammatory changes caused by Porphyromonas gingivalis with distinct fimA genotypes in a mouse abscess model. Nakano, K., Kuboniwa, M., Nakagawa, I., Yamamura, T., Nomura, R., Okahashi, N., Ooshima, T., Amano, A. Oral Microbiol. Immunol. (2004) [Pubmed]
  20. Fimbriae from the oral anaerobe Bacteroides gingivalis: physical, chemical, and immunological properties. Yoshimura, F., Takasawa, T., Yoneyama, M., Yamaguchi, T., Shiokawa, H., Suzuki, T. J. Bacteriol. (1985) [Pubmed]
  21. Association between infection of different strains of Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans in subgingival plaque and clinical parameters in chronic periodontitis. Wu, Y.M., Yan, J., Chen, L.L., Gu, Z.Y. Journal of Zhejiang University. Science. B. (2007) [Pubmed]
  22. Biofilm formation by the periodontopathic bacteria Treponema denticola and Porphyromonas gingivalis. Kuramitsu, H.K., Chen, W., Ikegami, A. J. Periodontol. (2005) [Pubmed]
  23. The prevalence and pathogenic differences of Porphyromonas gingivalis fimA genotypes in patients with aggressive periodontitis. Miura, M., Hamachi, T., Fujise, O., Maeda, K. J. Periodont. Res. (2005) [Pubmed]
  24. Isolation and characterization of a minor fimbria from Porphyromonas gingivalis. Hamada, N., Sojar, H.T., Cho, M.I., Genco, R.J. Infect. Immun. (1996) [Pubmed]
  25. Involvement of Porphyromonas gingivalis fimA genotype in treatment outcome following non-surgical periodontal therapy. Fujise, O., Miura, M., Hamachi, T., Maeda, K. J. Periodontol. (2005) [Pubmed]
  26. Prevalence of Porphyromonas gingivalis fimA genotypes in Caucasians. Beikler, T., Peters, U., Prajaneh, S., Prior, K., Ehmke, B., Flemmig, T.F. Eur. J. Oral Sci. (2003) [Pubmed]
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