Disease relevance of Olfr1

• These data indicate that olfactory receptor (OR) proteins are indeed present in the axonal processes and nerve terminals of olfactory sensory neurons, thus supporting the notion that ORs may participate in the molecular processes underlying the fasciculation and targeting of olfactory axons [1].

High impact information on Olfr1

• Allelic inactivation regulates olfactory receptor gene expression [2].
• Asynchronous DNA replication is an epigenetically determined feature found in all cases of monoallelic expression, including genomic imprinting, X-inactivation, and random monoallelic expression of autosomal genes such as immunoglobulins and olfactory receptor genes [3].
• For six mouse olfactory receptor genes from family 262 which are expressed in clustered populations of olfactory sensory neurons, the genomic as well as cDNA structures were deciphered [4].
• The clustered olfactory receptor gene family 262: genomic organization, promotor elements, and interacting transcription factors [4].
• Tissue and zonal-specific expression of an olfactory receptor transgene [5].

Biological context of Olfr1

• Sequence analyses of the olfactory receptor gene cluster mOR37 on mouse chromosome 4 [6].
• Nevertheless, although the physiology and neurochemistry of the olfactory circuits have been widely studied, the neurotransmitter released by olfactory receptor neurones remains unknown [7].
• A probabilistic classifier for olfactory receptor pseudogenes [8].
• Previously, we demonstrated that inefficient olfactory receptor (OR) expression at the plasma membrane is attributable, in part, to degradation of endoplasmic reticulum (ER)-retained ORs by the ubiquitin-proteasome system and sequestration of ORs in ER aggregates that are degraded by autophagy [9].

Anatomical context of Olfr1

• Although a subset of the olfactory receptor (OR) gene family is expressed in testis, neither their developmental profile nor their physiological functions have been fully characterized [10].
• Expression of these markers in olfactory receptor neurones during the first postnatal days reflects the advanced developmental state of this system compared to other regions of the central nervous system (such as the cortex and cerebellum), which are highly immature and less developed in comparison with those of new-born rats or mice [11].
• Higher concentrations (1%) of horseradish peroxidase penetrate olfactory receptor plasma membranes and intercellular junctions [12].
• At E18, CGRP-immunoreactive fibers, presumably of trigeminal, not olfactory receptor cell, origin were observed within the lamina propria [13].
• Using this protocol, nested degenerate PCR primers were designed to amplify members of the large and relatively homologous olfactory receptor (OR) gene family from RNA extracted from 125-microm diameter punches of tissue microdissected from 16-microm sections of the main olfactory bulb (MOB) of the mouse [14].

Associations of Olfr1 with chemical compounds

• The Molecular Basis for Ligand Specificity in a Mouse Olfactory Receptor: A NETWORK OF FUNCTIONALLY IMPORTANT RESIDUES [15].
• In insect olfactory receptor neurons, rapid and transient increases in inositol triphosphate (IP3) and Ca2+ are detected upon stimulation with pheromone or nonpheromonal odorants [16].
• As thyroxine is necessary for the correct development of the nervous system it may also be necessary for the genesis of new olfactory receptor neurones, a process that continues into adulthood [17].
• Here we show that stored isoeugenol has an antagonistic effect on a mouse olfactory receptor, mOR-EG [18].
• This suggests that there is a glyco-moiety associated with at least one olfactory receptor responding to nicotine [19].

Regulatory relationships of Olfr1

• The rodent olfactory epithelium consists of a mosaic of primary sensory olfactory neurons (PONs) which express distinct putative olfactory receptor proteins [20].

Other interactions of Olfr1

• Odorant responsiveness of a mouse olfactory receptor, mOR-EG, was investigated in various heterologous cells using a variety of detection methods [21].

Analytical, diagnostic and therapeutic context of Olfr1

• We have therefore designed a high-density oligonucleotide array containing all known mouse olfactory receptor (OR) and V1R vomeronasal receptor genes [22].
• The anatomy of the murine olfactory receptor was analyzed using high-resolution scanning electron microscopy with the aldehyde-osmium-dimethyl sulfoxide-osmium method [23].

References