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Gene Review

Olr1469  -  olfactory receptor Olr1469

Rattus norvegicus

Synonyms: Olfactory receptor 1, Olfactory receptor 1469, Olfactory receptor HGL-SP1, Olfactory receptor OR5, Olfactory receptor-like protein I54, ...
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Psychiatry related information on Olr1469

  • These results indicate that it is possible to functionally express mammalian olfactory receptors in providing a research tool to efficiently search for specific olfactory receptor ligands and to extend our understanding of the molecular basis of olfaction [1].

High impact information on Olr1469


Biological context of Olr1469

  • Rat foetuses from intra-uterine days E14 through E22 (day before parturition) and adults were used for a quantitative scanning electron-microscopic examination of ciliogenesis in olfactory receptor cells and microvillogenesis in olfactory supporting cells [7].
  • Action potentials initiated by single channels opening in a small neuron (rat olfactory receptor) [8].
  • Comparison of DNA sequences of the rat (Rattus norvegicus) olfactory receptor gene family revealed an unusual pattern of nucleotide substitution in the gene region encoding the second extracellular domain (E2) of the protein [9].
  • In this study we tested whether odors of different chemical structures produce maximal responses along longitudinally oriented regions following the olfactory receptor gene expression zones described in the literature [10].
  • We have subsequently demonstrated the presence of one of the corresponding olfactory receptor proteins during dog spermatogenesis and in mature sperm cells [11].

Anatomical context of Olr1469


Associations of Olr1469 with chemical compounds


Regulatory relationships of Olr1469


Other interactions of Olr1469


Analytical, diagnostic and therapeutic context of Olr1469


  1. Functional expression of a mammalian olfactory receptor in Caenorhabditis elegans. Milani, N., Guarin, E., Renfer, E., Nef, P., Andres-Barquin, P.J. Neuroreport (2002) [Pubmed]
  2. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. Parmentier, M., Libert, F., Schurmans, S., Schiffmann, S., Lefort, A., Eggerickx, D., Ledent, C., Mollereau, C., Gérard, C., Perret, J. Nature (1992) [Pubmed]
  3. Rapid activation of alternative second messenger pathways in olfactory cilia from rats by different odorants. Boekhoff, I., Tareilus, E., Strotmann, J., Breer, H. EMBO J. (1990) [Pubmed]
  4. Rat hippocampal neurons express genes for both rod retinal and olfactory cyclic nucleotide-gated channels: novel targets for cAMP/cGMP function. Kingston, P.A., Zufall, F., Barnstable, C.J. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  5. Specific olfactory receptor populations projecting to identified glomeruli in the rat olfactory bulb. Jastreboff, P.J., Pedersen, P.E., Greer, C.A., Stewart, W.B., Kauer, J.S., Benson, T.E., Shepherd, G.M. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  6. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. Ben-Arie, N., Lancet, D., Taylor, C., Khen, M., Walker, N., Ledbetter, D.H., Carrozzo, R., Patel, K., Sheer, D., Lehrach, H. Hum. Mol. Genet. (1994) [Pubmed]
  7. Genesis of cilia and microvilli of rat nasal epithelia during pre-natal development. II. Olfactory epithelium, a morphometric analysis. Menco, B.P., Farbman, A.I. J. Cell. Sci. (1985) [Pubmed]
  8. Action potentials initiated by single channels opening in a small neuron (rat olfactory receptor). Lynch, J.W., Barry, P.H. Biophys. J. (1989) [Pubmed]
  9. Adaptive evolution in the rat olfactory receptor gene family. Hughes, A.L., Hughes, M.K. J. Mol. Evol. (1993) [Pubmed]
  10. Spatially organized response zones in rat olfactory epithelium. Scott, J.W., Shannon, D.E., Charpentier, J., Davis, L.M., Kaplan, C. J. Neurophysiol. (1997) [Pubmed]
  11. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. Vanderhaeghen, P., Schurmans, S., Vassart, G., Parmentier, M. Genomics (1997) [Pubmed]
  12. Identification of olfactory receptor mRNA sequences from the rat olfactory bulb glomerular layer. Singer, M.S., Hughes, T.E., Shepherd, G.M., Greer, C.A. Neuroreport (1998) [Pubmed]
  13. Olfactory receptor trafficking involves conserved regulatory steps. Gimelbrant, A.A., Haley, S.L., McClintock, T.S. J. Biol. Chem. (2001) [Pubmed]
  14. Genesis of cilia and microvilli of rat nasal epithelia during pre-natal development. I. Olfactory epithelium, qualitative studies. Menco, B.P., Farbman, A.I. J. Cell. Sci. (1985) [Pubmed]
  15. Direct demonstration of a physiological role for carbon monoxide in olfactory receptor neurons. Ingi, T., Ronnett, G.V. J. Neurosci. (1995) [Pubmed]
  16. Olfactory ensheathing cells promote neurite extension from embryonic olfactory receptor cells in vitro. Kafitz, K.W., Greer, C.A. Glia (1999) [Pubmed]
  17. Identification of a specific olfactory receptor for 2-isobutyl-3-methoxypyrazine. Pelosi, P., Baldaccini, N.E., Pisanelli, A.M. Biochem. J. (1982) [Pubmed]
  18. Response of olfactory ensheathing cells to the degeneration and regeneration of the peripheral olfactory system and the involvement of the neuregulins. Williams, S.K., Franklin, R.J., Barnett, S.C. J. Comp. Neurol. (2004) [Pubmed]
  19. Expression of non-N-methyl-D-aspartate glutamate receptor subunits in the olfactory epithelium. Thukral, V., Chikaraishi, D., Hunter, D.D., Wang, J.K. Neuroscience (1997) [Pubmed]
  20. Expression of Golf in the rat placenta: Possible implication in olfactory receptor transduction. Itakura, S., Ohno, K., Ueki, T., Sato, K., Kanayama, N. Placenta (2006) [Pubmed]
  21. Widespread expression of olfactory cyclic nucleotide-gated channel genes in rat brain: implications for neuronal signalling. Kingston, P.A., Zufall, F., Barnstable, C.J. Synapse (1999) [Pubmed]
  22. Chemoreceptors expressed in taste, olfactory and male reproductive tissues. Thomas, M.B., Haines, S.L., Akeson, R.A. Gene (1996) [Pubmed]
  23. Olfactory receptor proteins. Expression, characterization and partial purification. Gat, U., Nekrasova, E., Lancet, D., Natochin, M. Eur. J. Biochem. (1994) [Pubmed]
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