Psychiatry related information on Olr1469

• These results indicate that it is possible to functionally express mammalian olfactory receptors in providing a research tool to efficiently search for specific olfactory receptor ligands and to extend our understanding of the molecular basis of olfaction [1].

High impact information on Olr1469

• Northern blotting further demonstrated the presence of olfactory receptor transcripts in germ cells [2].
• The molecular mechanisms mediating the chemo-electrical signal transduction in olfactory receptor cells are still elusive [3].
• PCR amplification detected the expression of transcripts for subunit 1 of both the rod photoreceptor (RCNGC1) and the olfactory receptor cell (OCNGC1) subtype of CNG channel in adult rat hippocampus [4].
• Specific olfactory receptor populations projecting to identified glomeruli in the rat olfactory bulb [5].
• Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire [6].

Biological context of Olr1469

• Rat foetuses from intra-uterine days E14 through E22 (day before parturition) and adults were used for a quantitative scanning electron-microscopic examination of ciliogenesis in olfactory receptor cells and microvillogenesis in olfactory supporting cells [7].
• Action potentials initiated by single channels opening in a small neuron (rat olfactory receptor) [8].
• Comparison of DNA sequences of the rat (Rattus norvegicus) olfactory receptor gene family revealed an unusual pattern of nucleotide substitution in the gene region encoding the second extracellular domain (E2) of the protein [9].
• In this study we tested whether odors of different chemical structures produce maximal responses along longitudinally oriented regions following the olfactory receptor gene expression zones described in the literature [10].
• We have subsequently demonstrated the presence of one of the corresponding olfactory receptor proteins during dog spermatogenesis and in mature sperm cells [11].

Anatomical context of Olr1469

• In situ hybridization has demonstrated mRNA for olfactory receptors (OR) in the axon terminals of olfactory receptor neurons [12].
• Expression of members of the putative olfactory receptor gene family in mammalian germ cells [2].
• They are typically retained in the endoplasmic reticulum of cells commonly used for functional expression studies and are only released to the plasma membrane in mature cells of the olfactory receptor neuron lineage [13].
• Olfactory receptor trafficking from the endoplasmic reticulum to the plasma membrane involves at least two steps whose regulation depends on the maturation state of cells in the olfactory receptor neuron lineage [13].
• This advance in development includes total densities of dendritic endings of olfactory receptor cells, densities of multiciliated endings alone and lengths of supporting cell microvilli [14].

Associations of Olr1469 with chemical compounds

• To examine the generation of CO by neurons, we measured CO production directly and determined its relationship to cyclic GMP levels in cultured rat olfactory receptor neurons [15].
• Direct demonstration of a physiological role for carbon monoxide in olfactory receptor neurons [15].
• Olfactory receptor cells were cocultured with ensheathing or hippocampal glial cells or were seeded on laminin or poly-L-lysine as controls [16].
• Identification of a specific olfactory receptor for 2-isobutyl-3-methoxypyrazine [17].
• In this study we examined the proliferative response of olfactory ensheathing cells (OECs) to olfactory receptor neuron injury induced by zinc sulfate (ZnSO4) irrigation and related the response of OECs within the peripheral system to the inflammatory response induced by injury and the expression profile of neuregulins [18].

Regulatory relationships of Olr1469

• Olfactory ensheathing cells promote neurite extension from embryonic olfactory receptor cells in vitro [16].

Other interactions of Olr1469

• Identification of olfactory receptor mRNA sequences from the rat olfactory bulb glomerular layer [12].
• Heme oxygenase-2 immunoreactivity is abundantly present in olfactory receptor neurons where it essentially colocalizes with immunoreactivity to soluble guanylyl cyclase, the target of CO action [15].
• In situ hybridization and immunocytochemistry localized KA2 to only the olfactory receptor neurons, and not to any other cell type in the olfactory epithelium [19].
• Expression of Golf in the rat placenta: Possible implication in olfactory receptor transduction [20].
• Previous studies have identified the expression of a gene encoding one major CNG channel subtype, the olfactory receptor neuron alpha subunit, in the brain [El-Husseini et al. (1995) NeuroReport 6:1331-1335; Kingston et al. (1996a) Proc. Natl. Acad. Sci. U.S.A. 93:10440-10445; Bradley et al. (1997) J. Neurosci. 17:1993-2085] [21].

Analytical, diagnostic and therapeutic context of Olr1469

• Rat olfactory receptor neurons were enzymatically dissociated and studied with the cell-attached configuration of the patch-clamp technique [8].
• Sequence analysis of three distinct clonal isolates revealed that the gene products from taste bud were 30-75% identical to previously identified olfactory receptor genes [22].
• Expression of olp4, as well as of another previously cloned olfactory receptor (F5), was monitored by immunoprecipitation was a monoclonal antibody directed against a Flag peptide epitope tag, inserted at the N-terminus of the open reading frame, and a specific polyclonal antibody against a C-terminal peptide of olp4 [23].
• By RT-PCR, we identified 11 different olfactory receptor genes, which are all members of class II, in the rat placenta cDNAs, and our results suggested that particular members of the olfactory receptor gene family might be preferentially expressed in the placenta [20].

References