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Gene Review

Map3k5  -  mitogen-activated protein kinase kinase...

Mus musculus

Synonyms: 7420452D20Rik, ASK, ASK-1, ASK1, Apoptosis signal-regulating kinase 1, ...
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Disease relevance of Map3k5


Psychiatry related information on Map3k5

  • These results indicate that ROS-mediated ASK1 activation is a key mechanism for Abeta-induced neurotoxicity, which plays a central role in Alzheimer's disease [6].

High impact information on Map3k5


Chemical compound and disease context of Map3k5


Biological context of Map3k5


Anatomical context of Map3k5


Associations of Map3k5 with chemical compounds

  • Liver protection from apoptosis requires both blockage of initiator caspase activities and inhibition of ASK1/JNK pathway via glutathione S-transferase regulation [13].
  • ASK1(-/-) cardiomyocytes were more resistant to H(2)O(2)- or Ca(2+)-induced apoptotic and non-apoptotic cell death compared with wild-type cells [14].
  • Left ventricular (LV) ASK1 was activated by Ang II infusion in wild-type mice, which was mediated by angiotensin II type 1 receptor and superoxide [8].
  • Treatment of a specific p38 inhibitor (SB203580) or overexpression of a kinase-defective mutant, ASK1 (K709R), promoted Fas-mediated cell death in HepG2 cells [15].
  • Bromodeoxyuridine labeling index at 7 days after injury showed that DN-ASK1 remarkably suppressed VSMC proliferation in both the intima and the media [16].
  • Transfection with an adenoviral construct including a dominant negative form of ASK1 gene significantly inhibited SA-beta-gal activity induced by high glucose [17].

Regulatory relationships of Map3k5


Other interactions of Map3k5


Analytical, diagnostic and therapeutic context of Map3k5


  1. ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Matsuzawa, A., Saegusa, K., Noguchi, T., Sadamitsu, C., Nishitoh, H., Nagai, S., Koyasu, S., Matsumoto, K., Takeda, K., Ichijo, H. Nat. Immunol. (2005) [Pubmed]
  2. Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. Yamaguchi, O., Watanabe, T., Nishida, K., Kashiwase, K., Higuchi, Y., Takeda, T., Hikoso, S., Hirotani, S., Asahi, M., Taniike, M., Nakai, A., Tsujimoto, I., Matsumura, Y., Miyazaki, J., Chien, K.R., Matsuzawa, A., Sadamitsu, C., Ichijo, H., Baccarini, M., Hori, M., Otsu, K. J. Clin. Invest. (2004) [Pubmed]
  3. Execution of macrophage apoptosis by Mycobacterium avium through apoptosis signal-regulating kinase 1/p38 mitogen-activated protein kinase signaling and caspase 8 activation. Bhattacharyya, A., Pathak, S., Basak, C., Law, S., Kundu, M., Basu, J. J. Biol. Chem. (2003) [Pubmed]
  4. Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo. Harada, C., Nakamura, K., Namekata, K., Okumura, A., Mitamura, Y., Iizuka, Y., Kashiwagi, K., Yoshida, K., Ohno, S., Matsuzawa, A., Tanaka, K., Ichijo, H., Harada, T. Am. J. Pathol. (2006) [Pubmed]
  5. Enhanced TNF-alpha-induced apoptosis in Fanconi anemia type C-deficient cells is dependent on apoptosis signal-regulating kinase 1. Bijangi-Vishehsaraei, K., Saadatzadeh, M.R., Werne, A., McKenzie, K.A., Kapur, R., Ichijo, H., Haneline, L.S. Blood (2005) [Pubmed]
  6. Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation. Kadowaki, H., Nishitoh, H., Urano, F., Sadamitsu, C., Matsuzawa, A., Takeda, K., Masutani, H., Yodoi, J., Urano, Y., Nagano, T., Ichijo, H. Cell Death Differ. (2005) [Pubmed]
  7. Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling. Yamaguchi, O., Higuchi, Y., Hirotani, S., Kashiwase, K., Nakayama, H., Hikoso, S., Takeda, T., Watanabe, T., Asahi, M., Taniike, M., Matsumura, Y., Tsujimoto, I., Hongo, K., Kusakari, Y., Kurihara, S., Nishida, K., Ichijo, H., Hori, M., Otsu, K. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  8. Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II-induced cardiac hypertrophy and remodeling. Izumiya, Y., Kim, S., Izumi, Y., Yoshida, K., Yoshiyama, M., Matsuzawa, A., Ichijo, H., Iwao, H. Circ. Res. (2003) [Pubmed]
  9. The antioxidant edaravone attenuates pressure overload-induced left ventricular hypertrophy. Tsujimoto, I., Hikoso, S., Yamaguchi, O., Kashiwase, K., Nakai, A., Takeda, T., Watanabe, T., Taniike, M., Matsumura, Y., Nishida, K., Hori, M., Kogo, M., Otsu, K. Hypertension (2005) [Pubmed]
  10. Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice. Hsieh, C.C., Papaconstantinou, J. FASEB J. (2006) [Pubmed]
  11. Role of TNF receptor-associated factor 2 and p38 mitogen-activated protein kinase activation during 4-1BB-dependent immune response. Cannons, J.L., Choi, Y., Watts, T.H. J. Immunol. (2000) [Pubmed]
  12. Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation. Takeda, K., Matsuzawa, A., Nishitoh, H., Tobiume, K., Kishida, S., Ninomiya-Tsuji, J., Matsumoto, K., Ichijo, H. EMBO Rep. (2004) [Pubmed]
  13. Liver protection from apoptosis requires both blockage of initiator caspase activities and inhibition of ASK1/JNK pathway via glutathione S-transferase regulation. Gilot, D., Loyer, P., Corlu, A., Glaise, D., Lagadic-Gossmann, D., Atfi, A., Morel, F., Ichijo, H., Guguen-Guillouzo, C. J. Biol. Chem. (2002) [Pubmed]
  14. Apoptosis signal-regulating kinase 1 is involved not only in apoptosis but also in non-apoptotic cardiomyocyte death. Watanabe, T., Otsu, K., Takeda, T., Yamaguchi, O., Hikoso, S., Kashiwase, K., Higuchi, Y., Taniike, M., Nakai, A., Matsumura, Y., Nishida, K., Ichijo, H., Hori, M. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  15. Hepatitis C virus core inhibits the Fas-mediated p38 mitogen activated kinase signaling pathway in hepatocytes. Yang, S.H., Lee, C.G., Lee, C.W., Choi, E.J., Yoon, S.K., Ahn, K.S., Sung, Y.C. Mol. Cells (2002) [Pubmed]
  16. Activation of apoptosis signal-regulating kinase 1 in injured artery and its critical role in neointimal hyperplasia. Izumi, Y., Kim, S., Yoshiyama, M., Izumiya, Y., Yoshida, K., Matsuzawa, A., Koyama, H., Nishizawa, Y., Ichijo, H., Yoshikawa, J., Iwao, H. Circulation (2003) [Pubmed]
  17. Apoptosis signal-regulating kinase 1 mediates cellular senescence induced by high glucose in endothelial cells. Yokoi, T., Fukuo, K., Yasuda, O., Hotta, M., Miyazaki, J., Takemura, Y., Kawamoto, H., Ichijo, H., Ogihara, T. Diabetes (2006) [Pubmed]
  18. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. Tobiume, K., Matsuzawa, A., Takahashi, T., Nishitoh, H., Morita , K., Takeda, K., Minowa, O., Miyazono, K., Noda, T., Ichijo, H. EMBO Rep. (2001) [Pubmed]
  19. Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation. Jung, H., Seong, H.A., Ha, H. J. Biol. Chem. (2008) [Pubmed]
  20. Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1. Tobiume, K., Inage, T., Takeda, K., Enomoto, S., Miyazono, K., Ichijo, H. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
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