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Gene Review

Txn1  -  thioredoxin 1

Mus musculus

Synonyms: ADF, ATL-derived factor, AW550880, Thioredoxin, Trx, ...
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Disease relevance of Txn1


Psychiatry related information on Txn1

  • Moreover, to clarify the difference between the embryo-protecting mechanisms of TRX and SOD, as well as the critical periods of their actions, we carried out experiments in which we transferred embryos among three different media: basic, TRX- and SOD-supplemented [6].

High impact information on Txn1


Chemical compound and disease context of Txn1


Biological context of Txn1


Anatomical context of Txn1

  • Studies with human thioredoxin-1 (Trx-1)-transgenic (Tg) mice were conducted to evaluate the relationship between stimulation of T-cell mitogenic response by sodium selenite and the intracellular Trx-1 levels, and the activities of selenoenzymes and NF-kappaB-DNA binding [18].
  • Immunohistochemical localization of thioredoxin and glutaredoxin in mouse embryos and fetuses [19].
  • LIM kinase 1 regulates actin filament dynamics through inhibition of ADF/cofilins [20].
  • We conclude that the rapid E2-mediated activation of the Txn pathway is an important step in the response of the mammalian uterus to estrogen [21].
  • Our results provide strong genetic evidence that LIMK and its substrate ADF/cofilin are involved in spine morphology and synaptic properties and are consistent with the notion that the Rho family small GTPases and the actin cytoskeleton are critical to spine structure and synaptic regulation [22].

Associations of Txn1 with chemical compounds


Physical interactions of Txn1

  • These results suggest that the stimulation of T-cell mitogenic response by the physiological levels of selenite is predominantly caused by increased TR activity, which may lead to reduction of Trx-1 dependent on the intracellular expression level and promotion of DNA binding of NF-kappaB [18].

Regulatory relationships of Txn1


Other interactions of Txn1


Analytical, diagnostic and therapeutic context of Txn1


  1. Impaired spermatogenic ability of testicular germ cells in mice deficient in the LIM-kinase 2 gene. Takahashi, H., Koshimizu, U., Miyazaki, J., Nakamura, T. Dev. Biol. (2002) [Pubmed]
  2. Overexpression of thioredoxin prevents acute hepatitis caused by thioacetamide or lipopolysaccharide in mice. Okuyama, H., Nakamura, H., Shimahara, Y., Araya, S., Kawada, N., Yamaoka, Y., Yodoi, J. Hepatology (2003) [Pubmed]
  3. Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene. Matsui, M., Oshima, M., Oshima, H., Takaku, K., Maruyama, T., Yodoi, J., Taketo, M.M. Dev. Biol. (1996) [Pubmed]
  4. Helicobacter felis-induced gastritis was suppressed in mice overexpressing thioredoxin-1. Kawasaki, K., Nishio, A., Nakamura, H., Uchida, K., Fukui, T., Ohana, M., Yoshizawa, H., Ohashi, S., Tamaki, H., Matsuura, M., Asada, M., Nishi, T., Nakase, H., Toyokuni, S., Liu, W., Yodoi, J., Okazaki, K., Chiba, T. Lab. Invest. (2005) [Pubmed]
  5. Overexpression of redox-active protein thioredoxin-1 prevents development of chronic pancreatitis in mice. Ohashi, S., Nishio, A., Nakamura, H., Asada, M., Tamaki, H., Kawasaki, K., Fukui, T., Yodoi, J., Chiba, T. Antioxid. Redox Signal. (2006) [Pubmed]
  6. Protection from oxidative stress by thioredoxin and superoxide dismutase of mouse embryos fertilized in vitro. Nonogaki, T., Noda, Y., Narimoto, K., Umaoka, Y., Mori, T. Hum. Reprod. (1991) [Pubmed]
  7. Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells. Yamawaki, H., Pan, S., Lee, R.T., Berk, B.C. J. Clin. Invest. (2005) [Pubmed]
  8. Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy. Yamamoto, M., Yang, G., Hong, C., Liu, J., Holle, E., Yu, X., Wagner, T., Vatner, S.F., Sadoshima, J. J. Clin. Invest. (2003) [Pubmed]
  9. A crucial role for thiol antioxidants in estrogen-deficiency bone loss. Lean, J.M., Davies, J.T., Fuller, K., Jagger, C.J., Kirstein, B., Partington, G.A., Urry, Z.L., Chambers, T.J. J. Clin. Invest. (2003) [Pubmed]
  10. Catalase-overexpressing thymocytes are resistant to glucocorticoid-induced apoptosis and exhibit increased net tumor growth. Tome, M.E., Baker, A.F., Powis, G., Payne, C.M., Briehl, M.M. Cancer Res. (2001) [Pubmed]
  11. Overexpression of thioredoxin prevents thioacetamide-induced hepatic fibrosis in mice. Okuyama, H., Nakamura, H., Shimahara, Y., Uyama, N., Kwon, Y.W., Kawada, N., Yamaoka, Y., Yodoi, J. J. Hepatol. (2005) [Pubmed]
  12. Thioredoxin peroxidase-1 (peroxiredoxin-1) is increased in thioredoxin-1 transfected cells and results in enhanced protection against apoptosis caused by hydrogen peroxide but not by other agents including dexamethasone, etoposide, and doxorubicin. Berggren, M.I., Husbeck, B., Samulitis, B., Baker, A.F., Gallegos, A., Powis, G. Arch. Biochem. Biophys. (2001) [Pubmed]
  13. Absolute gene expression patterns of thioredoxin and glutaredoxin redox systems in mouse. Jurado, J., Prieto-Alamo, M.J., Madrid-Rísquez, J., Pueyo, C. J. Biol. Chem. (2003) [Pubmed]
  14. Mouse thioredoxin gene maps on chromosome 4, whereas its pseudogene maps on chromosome 1. Taketo, M., Matsui, M., Rochelle, J.M., Yodoi, J., Seldin, M.F. Genomics (1994) [Pubmed]
  15. Thioredoxin reductase and cancer cell growth inhibition by organogold(III) compounds. Engman, L., McNaughton, M., Gajewska, M., Kumar, S., Birmingham, A., Powis, G. Anticancer Drugs (2006) [Pubmed]
  16. Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function. Junn, E., Han, S.H., Im, J.Y., Yang, Y., Cho, E.W., Um, H.D., Kim, D.K., Lee, K.W., Han, P.L., Rhee, S.G., Choi, I. J. Immunol. (2000) [Pubmed]
  17. Change of redox status and modulation by thiol replenishment in retinal photooxidative damage. Tanito, M., Nishiyama, A., Tanaka, T., Masutani, H., Nakamura, H., Yodoi, J., Ohira, A. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  18. Contribution of Thioredoxin Reductase to T-Cell Mitogenesis and NF-kB DNA-Binding Promoted by Selenite. Ueno, H., Kajihara, H., Nakamura, H., Yodoi, J., Nakamuro, K. Antioxid. Redox Signal. (2007) [Pubmed]
  19. Immunohistochemical localization of thioredoxin and glutaredoxin in mouse embryos and fetuses. Kobayashi, M., Nakamura, H., Yodoi, J., Shiota, K. Antioxid. Redox Signal. (2000) [Pubmed]
  20. Head, neck, and spines: a role for LIMK-1 in the hippocampus. Sarmiere, P.D., Bamburg, J.R. Neuron (2002) [Pubmed]
  21. Estradiol regulates the thioredoxin antioxidant system in the mouse uterus. Deroo, B.J., Hewitt, S.C., Peddada, S.D., Korach, K.S. Endocrinology (2004) [Pubmed]
  22. Regulation of spine morphology and synaptic function by LIMK and the actin cytoskeleton. Meng, Y., Zhang, Y., Tregoubov, V., Falls, D.L., Jia, Z. Reviews in the neurosciences. (2003) [Pubmed]
  23. Evidence for an age-related attenuation of cerebral microvascular antioxidant response to oxidative stress. Williams, W.M., Chung, Y.W. Life Sci. (2006) [Pubmed]
  24. Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems. Sun, Q.A., Kirnarsky, L., Sherman, S., Gladyshev, V.N. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  25. B-Raf acts via the ROCKII/LIMK/cofilin pathway to maintain actin stress fibers in fibroblasts. Pritchard, C.A., Hayes, L., Wojnowski, L., Zimmer, A., Marais, R.M., Norman, J.C. Mol. Cell. Biol. (2004) [Pubmed]
  26. Circulating thioredoxin suppresses lipopolysaccharide-induced neutrophil chemotaxis. Nakamura, H., Herzenberg, L.A., Bai, J., Araya, S., Kondo, N., Nishinaka, Y., Herzenberg, L.A., Yodoi, J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  27. Effect of catalase and thioredoxin addition to sperm incubation medium before in vitro fertilization on sperm capacity to support embryo development. Kuribayashi, Y., Gagnon, C. Fertil. Steril. (1996) [Pubmed]
  28. Ontogenesis of anti-oxidative enzymes in mouse embryos and fetuses: an immunohistochemical study. Kobayashi, M., Nakamura, H., Yodoi, J., Shiota, K. Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia. (2001) [Pubmed]
  29. Lens-specific regulation of the thioredoxin-1 gene, but not thioredoxin-2, upon in vivo photochemical oxidative stress in the Emory mouse. Reddy, P.G., Bhuyan, D.K., Bhuyan, K.C. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  30. Structure of the mouse thioredoxin-encoding gene and its processed pseudogene. Matsui, M., Taniguchi, Y., Hirota, K., Taketo, M., Yodoi, J. Gene (1995) [Pubmed]
  31. Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative sigma factor, SigH. Kaushal, D., Schroeder, B.G., Tyagi, S., Yoshimatsu, T., Scott, C., Ko, C., Carpenter, L., Mehrotra, J., Manabe, Y.C., Fleischmann, R.D., Bishai, W.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  32. Elevation of antioxidant potency in the brain of mice by low-dose gamma-ray irradiation and its effect on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced brain damage. Kojima, S., Matsuki, O., Nomura, T., Yamaoka, K., Takahashi, M., Niki, E. Free Radic. Biol. Med. (1999) [Pubmed]
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