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Gene Review

Fasn  -  fatty acid synthase

Rattus norvegicus

Synonyms: Fatty acid synthase
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Disease relevance of Fasn


High impact information on Fasn


Chemical compound and disease context of Fasn


Biological context of Fasn


Anatomical context of Fasn


Associations of Fasn with chemical compounds


Regulatory relationships of Fasn


Other interactions of Fasn


Analytical, diagnostic and therapeutic context of Fasn


  1. Upregulation of fatty acid synthase gene expression in experimental chronic renal failure. Szolkiewicz, M., Nieweglowski, T., Korczynska, J., Sucajtys, E., Stelmanska, E., Goyke, E., Swierczynski, J., Rutkowski, B. Metab. Clin. Exp. (2002) [Pubmed]
  2. Sterol regulatory element-binding protein-1c mimics the negative effect of insulin on phosphoenolpyruvate carboxykinase (GTP) gene transcription. Chakravarty, K., Leahy, P., Becard, D., Hakimi, P., Foretz, M., Ferre, P., Foufelle, F., Hanson, R.W. J. Biol. Chem. (2001) [Pubmed]
  3. C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism. Landree, L.E., Hanlon, A.L., Strong, D.W., Rumbaugh, G., Miller, I.M., Thupari, J.N., Connolly, E.C., Huganir, R.L., Richardson, C., Witters, L.A., Kuhajda, F.P., Ronnett, G.V. J. Biol. Chem. (2004) [Pubmed]
  4. Heterologously expressed acyl carrier protein domain of rat fatty acid synthase functions in Escherichia coli fatty acid synthase and Streptomyces coelicolor polyketide synthase systems. Tropf, S., Revill, W.P., Bibb, M.J., Hopwood, D.A., Schweizer, M. Chem. Biol. (1998) [Pubmed]
  5. Keratinocyte growth factor and the transcription factors C/EBP alpha, C/EBP delta, and SREBP-1c regulate fatty acid synthesis in alveolar type II cells. Mason, R.J., Pan, T., Edeen, K.E., Nielsen, L.D., Zhang, F., Longphre, M., Eckart, M.R., Neben, S. J. Clin. Invest. (2003) [Pubmed]
  6. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Foretz, M., Guichard, C., Ferré, P., Foufelle, F. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  7. Roles of Ser101, Asp236, and His237 in catalysis of thioesterase II and of the C-terminal region of the enzyme in its interaction with fatty acid synthase. Tai, M.H., Chirala, S.S., Wakil, S.J. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  8. Intron-exon organization of the gene for the multifunctional animal fatty acid synthase. Amy, C.M., Williams-Ahlf, B., Naggert, J., Smith, S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  9. Stearoyl-acyl-carrier-protein desaturase from higher plants is structurally unrelated to the animal and fungal homologs. Shanklin, J., Somerville, C. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  10. DNase I hypersensitivity sites and nuclear protein binding on the fatty acid synthase gene: identification of an element with properties similar to known glucose-responsive elements. Foufelle, F., Lepetit, N., Bosc, D., Delzenne, N., Morin, J., Raymondjean, M., Ferré, P. Biochem. J. (1995) [Pubmed]
  11. Fatty acid synthase is a potential molecular target for the chemoprevention of breast cancer. Lu, S., Archer, M.C. Carcinogenesis (2005) [Pubmed]
  12. Transcriptional regulation of the rat fatty acid synthase gene: identification and functional analysis of positive and negative effectors of basal transcription. Oskouian, B., Rangan, V.S., Smith, S. Biochem. J. (1996) [Pubmed]
  13. Theaflavin-3,3'-digallate and penta-O-galloyl-beta-D-glucose inhibit rat liver microsomal 5alpha-reductase activity and the expression of androgen receptor in LNCaP prostate cancer cells. Lee, H.H., Ho, C.T., Lin, J.K. Carcinogenesis (2004) [Pubmed]
  14. Intracerebroventricular C75 decreases meal frequency and reduces AgRP gene expression in rats. Aja, S., Bi, S., Knipp, S.B., McFadden, J.M., Ronnett, G.V., Kuhajda, F.P., Moran, T.H. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2006) [Pubmed]
  15. Rosiglitazone up-regulates lipoprotein lipase, hormone-sensitive lipase and uncoupling protein-1, and down-regulates insulin-induced fatty acid synthase gene expression in brown adipocytes of Wistar rats. Teruel, T., Hernandez, R., Rial, E., Martin-Hidalgo, A., Lorenzo, M. Diabetologia (2005) [Pubmed]
  16. Molecular cloning and sequencing of cDNAs encoding the entire rat fatty acid synthase. Amy, C.M., Witkowski, A., Naggert, J., Williams, B., Randhawa, Z., Smith, S. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  17. Rat mammary gland fatty acid synthase: localization of the constituent domains and two functional polyadenylation/termination signals in the cDNA. Schweizer, M., Takabayashi, K., Laux, T., Beck, K.F., Schreglmann, R. Nucleic Acids Res. (1989) [Pubmed]
  18. A high glycemic index starch diet affects lipid storage-related enzymes in normal and to a lesser extent in diabetic rats. Kabir, M., Rizkalla, S.W., Quignard-Boulangé, A., Guerre-Millo, M., Boillot, J., Ardouin, B., Luo, J., Slama, G. J. Nutr. (1998) [Pubmed]
  19. Diazoxide down-regulates leptin and lipid metabolizing enzymes in adipose tissue of Zucker rats. Standridge, M., Alemzadeh, R., Zemel, M., Koontz, J., Moustaid-Moussa, N. FASEB J. (2000) [Pubmed]
  20. Site-specific changes in the expression of fat-partitioning genes in weanling rats exposed to a low-protein diet in utero. Maloney, C.A., Gosby, A.K., Phuyal, J.L., Denyer, G.S., Bryson, J.M., Caterson, I.D. Obes. Res. (2003) [Pubmed]
  21. On the mechanism of the hypolipidemic effect of sulfur-substituted hexadecanedioic acid (3-thiadicarboxylic acid) in normolipidemic rats. Skorve, J., al-Shurbaji, A., Asiedu, D., Björkhem, I., Berglund, L., Berge, R.K. J. Lipid Res. (1993) [Pubmed]
  22. Nutritional control of rat liver fatty acid synthase and S14 mRNA abundance. Clarke, S.D., Armstrong, M.K., Jump, D.B. J. Nutr. (1990) [Pubmed]
  23. Effects of a fish oil-lard diet on rat plasma lipoproteins, liver FAS, and lipolytic enzymes. Benhizia, F., Hainault, I., Serougne, C., Lagrange, D., Hajduch, E., Guichard, C., Malewiak, M.I., Quignard-Boulangé, A., Lavau, M., Griglio, S. Am. J. Physiol. (1994) [Pubmed]
  24. A modest glucokinase overexpression in the liver promotes fed expression levels of glycolytic and lipogenic enzyme genes in the fasted state without altering SREBP-1c expression. Scott, D.K., Collier, J.J., Doan, T.T., Bunnell, A.S., Daniels, M.C., Eckert, D.T., O'Doherty, R.M. Mol. Cell. Biochem. (2003) [Pubmed]
  25. Different sterol regulatory element-binding protein-1 isoforms utilize distinct co-regulatory factors to activate the promoter for fatty acid synthase. Magaña, M.M., Koo, S.H., Towle, H.C., Osborne, T.F. J. Biol. Chem. (2000) [Pubmed]
  26. Role of hexosamine biosynthesis in glucose-mediated up-regulation of lipogenic enzyme mRNA levels: effects of glucose, glutamine, and glucosamine on glycerophosphate dehydrogenase, fatty acid synthase, and acetyl-CoA carboxylase mRNA levels. Rumberger, J.M., Wu, T., Hering, M.A., Marshall, S. J. Biol. Chem. (2003) [Pubmed]
  27. Impaired beta-adrenergic receptor-mediated regulation of gene expression in adipocytes from older rats. Shilo, L., Chin, J.H., Hoffman, B.B. Am. J. Physiol. (1994) [Pubmed]
  28. Influence of age and exercise training on lipid metabolism in Fischer-344 rats. Barakat, H.A., Dohm, G.L., Shukla, N., Marks, R.H., Kern, M., Carpenter, J.W., Mazzeo, R.S. J. Appl. Physiol. (1989) [Pubmed]
  29. Lipogenesis in fetal rat lung: importance of C/EBPalpha, SREBP-1c, and stearoyl-CoA desaturase. Zhang, F., Pan, T., Nielsen, L.D., Mason, R.J. Am. J. Respir. Cell Mol. Biol. (2004) [Pubmed]
  30. Metabolic regulation of leptin production in adipocytes: a role of fatty acid synthesis intermediates. Shirai, Y., Yaku, S., Suzuki, M. J. Nutr. Biochem. (2004) [Pubmed]
  31. Effects of capsinoid on serum and liver lipids in hyperlipidemic rats. Tani, Y., Fujioka, T., Sumioka, M., Furuichi, Y., Hamada, H., Watanabe, T. J. Nutr. Sci. Vitaminol. (2004) [Pubmed]
  32. Identification of an inverted CCAAT box motif in the fatty-acid synthase gene as an essential element for modification of transcriptional regulation by cAMP. Rangan, V.S., Oskouian, B., Smith, S. J. Biol. Chem. (1996) [Pubmed]
  33. The carboxyl-terminal region of thioesterase II participates in the interaction with fatty acid synthase. Use of electrospray ionization mass spectrometry to identify a carboxyl-terminally truncated form of the enzyme. Witkowska, H.E., Green, B.N., Smith, S. J. Biol. Chem. (1990) [Pubmed]
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