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Gene Review

B4GALT1  -  UDP-Gal:betaGlcNAc beta 1,4-...

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Disease relevance of B4GALT1


High impact information on B4GALT1

  • Here we solved and refined the crystal structures of recombinant bovine beta4Gal-T1 to 2.4 A resolution in the presence and absence of the substrate uridine diphosphogalactose [4].
  • The crystal structure of the bovine substrate-free beta4Gal-T1 catalytic domain showed a new fold consisting of a single conical domain with a large open pocket at its base [4].
  • In mammals, beta4Gal-T1 binds to alpha-lactalbumin, a protein that is structurally homologous to lyzozyme, to produce lactose. beta4Gal-T1 is a member of a large family of homologous beta4galactosyltransferases that use different types of glycoproteins and glycolipids as substrates [4].
  • These results help the interpretation of engineered beta4Gal-T1 point mutations [4].
  • Expression of bovine beta-1,4-galactosyltransferase cDNA in COS-7 cells [5].

Chemical compound and disease context of B4GALT1


Biological context of B4GALT1


Anatomical context of B4GALT1


Associations of B4GALT1 with chemical compounds


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  3. Synthesis and evaluation of mimetics of UDP and UDP-alpha-D-galactose, dTDP and dTDP-alpha-D-glucose with monosaccharides replacing the key pyrophosphate unit. Ballell, L., Young, R.J., Field, R.A. Org. Biomol. Chem. (2005) [Pubmed]
  4. Crystal structures of the bovine beta4galactosyltransferase catalytic domain and its complex with uridine diphosphogalactose. Gastinel, L.N., Cambillau, C., Bourne, Y. EMBO J. (1999) [Pubmed]
  5. Expression of bovine beta-1,4-galactosyltransferase cDNA in COS-7 cells. Masibay, A.S., Qasba, P.K. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
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  7. Effect of the Met344His mutation on the conformational dynamics of bovine beta-1,4-galactosyltransferase: crystal structure of the Met344His mutant in complex with chitobiose. Ramakrishnan, B., Boeggeman, E., Qasba, P.K. Biochemistry (2004) [Pubmed]
  8. Flexibility in the donor substrate specificity of beta 1,4-galactosyltransferase: application in the synthesis of complex carbohydrates. Palcic, M.M., Hindsgaul, O. Glycobiology (1991) [Pubmed]
  9. Selective inhibition of beta-1,4- and alpha-1,3-galactosyltransferases: donor sugar-nucleotide based approach. Takayama, S., Chung, S.J., Igarashi, Y., Ichikawa, Y., Sepp, A., Lechler, R.I., Wu, J., Hayashi, T., Siuzdak, G., Wong, C.H. Bioorg. Med. Chem. (1999) [Pubmed]
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  11. Evidence for a sialic acid salvaging pathway in lepidopteran insect cells. Hollister, J., Conradt, H., Jarvis, D.L. Glycobiology (2003) [Pubmed]
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  13. Enzymatic modification of natural compounds with pharmacological properties. Riva, S., Monti, D., Luisetti, M., Danieli, B. Ann. N. Y. Acad. Sci. (1998) [Pubmed]
  14. Crystal structure of lactose synthase reveals a large conformational change in its catalytic component, the beta1,4-galactosyltransferase-I. Ramakrishnan, B., Qasba, P.K. J. Mol. Biol. (2001) [Pubmed]
  15. Synthesis of poly-N-acetyllactosamine in core 2 branched O-glycans. The requirement of novel beta-1,4-galactosyltransferase IV and beta-1,3-n-acetylglucosaminyltransferase. Ujita, M., McAuliffe, J., Schwientek, T., Almeida, R., Hindsgaul, O., Clausen, H., Fukuda, M. J. Biol. Chem. (1998) [Pubmed]
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