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Chemical Compound Review

PNALA     N-[(2R,3R,4R,5R)-3,5,6- trihydroxy-1-oxo-4...

Synonyms: HMDB06583, AR-1D7970, FT-0629825, AC1L3P0E, AC1Q6A6K, ...
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Disease relevance of N-acetyllactosamine


High impact information on N-acetyllactosamine


Chemical compound and disease context of N-acetyllactosamine


Biological context of N-acetyllactosamine


Anatomical context of N-acetyllactosamine


Associations of N-acetyllactosamine with other chemical compounds


Gene context of N-acetyllactosamine


Analytical, diagnostic and therapeutic context of N-acetyllactosamine


  1. Relationship of the terminal sequences to the length of poly-N-acetyllactosamine chains in asparagine-linked oligosaccharides from the mouse lymphoma cell line BW5147. Immobilized tomato lectin interacts with high affinity with glycopeptides containing long poly-N-acetyllactosamine chains. Merkle, R.K., Cummings, R.D. J. Biol. Chem. (1987) [Pubmed]
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  6. Expression cloning of cDNA encoding a human beta-1,3-N-acetylglucosaminyltransferase that is essential for poly-N-acetyllactosamine synthesis. Sasaki, K., Kurata-Miura, K., Ujita, M., Angata, K., Nakagawa, S., Sekine, S., Nishi, T., Fukuda, M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
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  10. Cell interactions in preimplantation embryos: evidence for involvement of saccharides of the poly-N-acetyllactosamine series. Rastan, S., Thorpe, S.J., Scudder, P., Brown, S., Gooi, H.C., Feizi, T. Journal of embryology and experimental morphology. (1985) [Pubmed]
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  14. A high degree of sequence homology in the putative carbohydrate recognition domains of pokeweed mitogen and wheat germ agglutinin: poly-N-acetyllactosamine-binding lectins from different species. Konami, Y., Uno, T., Fujii, M., Yamamoto, K., Osawa, T., Irimura, T. Glycobiology (1995) [Pubmed]
  15. Identification of N-acetylneuraminyl alpha 2-->3 poly-N-acetyllactosamine glycans as the receptors of sialic acid-binding Streptococcus suis strains. Liukkonen, J., Haataja, S., Tikkanen, K., Kelm, S., Finne, J. J. Biol. Chem. (1992) [Pubmed]
  16. The poly-N-acetyllactosamines attached to lysosomal membrane glycoproteins are increased by the prolonged association with the Golgi complex. Wang, W.C., Lee, N., Aoki, D., Fukuda, M.N., Fukuda, M. J. Biol. Chem. (1991) [Pubmed]
  17. Granulocytic differentiation of HL-60 cells is associated with increase of poly-N-acetyllactosamine in Asn-linked oligosaccharides attached to human lysosomal membrane glycoproteins. Lee, N., Wang, W.C., Fukuda, M. J. Biol. Chem. (1990) [Pubmed]
  18. Poly-N-acetyllactosamine structures on murine cell surface T200 glycoprotein participate in natural killer cell binding to YAC-1 targets. Gilbert, C.W., Zaroukian, M.H., Esselman, W.J. J. Immunol. (1988) [Pubmed]
  19. The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine. Moore, K.L., Eaton, S.F., Lyons, D.E., Lichenstein, H.S., Cummings, R.D., McEver, R.P. J. Biol. Chem. (1994) [Pubmed]
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  25. A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer. Ishida, H., Togayachi, A., Sakai, T., Iwai, T., Hiruma, T., Sato, T., Okubo, R., Inaba, N., Kudo, T., Gotoh, M., Shoda, J., Tanaka, N., Narimatsu, H. FEBS Lett. (2005) [Pubmed]
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  27. Specific inhibition of T-cell adhesion to extracellular matrix and proinflammatory cytokine secretion by human recombinant galectin-1. Rabinovich, G.A., Ariel, A., Hershkoviz, R., Hirabayashi, J., Kasai, K.I., Lider, O. Immunology (1999) [Pubmed]
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  29. Construction and characterization of Haemophilus ducreyi lipooligosaccharide (LOS) mutants defective in expression of heptosyltransferase III and beta1,4-glucosyltransferase: identification of LOS glycoforms containing lactosamine repeats. Filiatrault, M.J., Gibson, B.W., Schilling, B., Sun, S., Munson, R.S., Campagnari, A.A. Infect. Immun. (2000) [Pubmed]
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  31. A multiplicity of erythrocyte glycolipids of the neolacto series revealed by immuno-thin-layer chromatography with monoclonal anti-I and anti-i antibodies. Uemura, K., Childs, R.A., Hanfland, P., Feizi, T. Biosci. Rep. (1983) [Pubmed]
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