Gene Review:
Testin - testin gene
Rattus norvegicus
Synonyms:
CMB-23, Testin-2
- Identification of two testosterone-responsive testicular proteins in Sertoli cell-enriched culture medium whose secretion is suppressed by cells of the intact seminiferous tubule. Cheng, C.Y., Bardin, C.W. J. Biol. Chem. (1987)
- Testin secreted by Sertoli cells is associated with the cell surface, and its expression correlates with the disruption of Sertoli-germ cell junctions but not the inter-Sertoli tight junction. Grima, J., Wong, C.C., Zhu, L.J., Zong, S.D., Cheng, C.Y. J. Biol. Chem. (1998)
- Testins are localized to the junctional complexes of rat Sertoli and epididymal cells. Zong, S.D., Bardin, C.W., Phillips, D., Cheng, C.Y. Biol. Reprod. (1992)
- Immunohistochemical localization of testin in the female reproductive system of the rat is consistent with its involvement in the turnover of specialized junctional complexes. Zhu, L., Moo-Young, A., Bardin, C.W., Cheng, C.Y. Biol. Reprod. (1997)
- Testin induction: the role of cyclic 3',5'-adenosine monophosphate/protein kinase A signaling in the regulation of basal and lonidamine-induced testin expression by rat sertoli cells. Grima, J., Cheng, C.Y. Biol. Reprod. (2000)
- Testins are structurally related to the mouse cysteine proteinase precursor but devoid of any protease/anti-protease activity. Cheng, C.Y., Morris, I., Bardin, C.W. Biochem. Biophys. Res. Commun. (1993)
- Rat testin is a newly identified component of the junctional complexes in various tissues whose mRNA is predominantly expressed in the testis and ovary. Grima, J., Zhu, L.J., Zong, S.D., Catterall, J.F., Bardin, C.W., Cheng, C.Y. Biol. Reprod. (1995)
- Testin is tightly associated with testicular cell membrane upon its secretion by sertoli cells whose steady-state mRNA level in the testis correlates with the turnover and integrity of inter-testicular cell junctions. Grima, J., Zhu, L., Cheng, C.Y. J. Biol. Chem. (1997)
- Effects of TCDD in modulating the expression of Sertoli cell secretory products and markers for cell-cell interaction. Lai, K.P., Wong, M.H., Wong, C.K. Toxicology (2005)
- Testins are structurally related Sertoli cell proteins whose secretion is tightly coupled to the presence of germ cells. Cheng, C.Y., Grima, J., Stahler, M.S., Lockshin, R.A., Bardin, C.W. J. Biol. Chem. (1989)
- Ability of trypsin in mimicking germ cell factors that affect Sertoli cell secretory function. Aravindan, G.R., Pineau, C.P., Bardin, C.W., Cheng, C.Y. J. Cell. Physiol. (1996)