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ANKRD11  -  ankyrin repeat domain 11

Homo sapiens

Synonyms: ANCO-1, ANCO1, Ankyrin repeat domain-containing protein 11, Ankyrin repeat-containing cofactor 1, LZ16, ...
 
 
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Disease relevance of ANKRD11

  • The human T acute lymphocytic leukemia cell line, SUP-T13, is a mosaic of TCR/CD3+ and TCR/CD3- cells [1].
  • By using peptide phage-displayed technology, we identified three critical motifs, LXPEXD, QSYP, and EX(E/D)PPV, within selected mimotopes which interacted with the human recombinant anti-TPO autoantibody (aAb) T13, derived from an antibody phage-displayed library obtained from thyroid-infiltrating TPO-selected B cells of Graves' disease patients [2].
  • T13 spinal cord hemisection resulted in central neuropathic pain manifested by mechanical allodynia and thermal hyperalgesia [3].
  • The M1inv+ subclone was found to harbor two entirely different prophages, phage T13 and phage T14, which together supplement its genome with nearly 70 kb of DNA [4].
  • To assess the role of these genes in other leukemia-associated translocations we mapped their locations with respect to the t(11;19)(q23;p13) and t(4;19)(q21;p13) translocation breakpoints carried by T-ALL cell lines SUP-T13 and SUP-T8a, respectively [5].
 

High impact information on ANKRD11

  • An electrophysiological classification of the AV nodal area, based on transmembrane action potential characteristics during various imposed atrial rhythms (rapid pacing, trains of premature impulses), into AN (including ANCO and ANL), N, and NH zones has been described by various authors for the rabbit heart [6].
  • We then analyzed four hematopoietic cell lines with 11q23 rearrangements, Karpas 45, SUP-T13, RC-K8, and Karpas 422, using these probes [7].
  • RESULTS: We found activation of microglia and increased expression of TNF-alpha below the level of the lesion in the lumbar spinal cord after T13 lateral hemisection that correlated with emergence of mechanical allodynia in the hind limbs of rats [8].
  • Transient reporter gene assay shows that ANCO-1 expression inhibits ligand-dependent transactivation by both steroid and nonsteroid nuclear receptors [9].
  • ANCO-1 binds to the conserved Per-Arnt-Sim (PAS) region of the p160 coactivators [9].
 

Chemical compound and disease context of ANKRD11

  • In a rodent SCI model, T13 unilateral spinal hemisection results in bilateral mechanical allodynia and thermal hyperalgesia, partly by interruption of tonic descending serotonin (5-HT) inhibition [10].
 

Biological context of ANKRD11

  • Amino acid sequence and mass spectrometric analysis demonstrated the substitution of Arg----Cys residue in position 89 producing an uncleaved T12-T13 present in the same peak as the T6 [11].
  • The SUP-T13 cell line, a human T leukemia, is susceptible to apoptosis by various inducers, including anti-TCR mAb, calcium ionophores, and anti-fas mAb [12].
  • An anti-T cell receptor (TcR) monoclonal antibody (mAb), LC4, directed against a human leukemic T cell line, SUP-T13, caused DNA fragmentation ("apoptosis") and cell death upon binding to this cell line [13].
  • There are significant temperature-dependent changes in the conformations of the central base-pairs from T9 to T13 with the largest changes in the glycosidic torsion angle occurring for A11 and A12 (up to 30 degrees) [14].
  • A statistically significant association with resistance patterns was found: T12 with erythromycin resistance MLS(B) CR phenotype (p< 0.001), T4 with erythromycin resistance M phenotype (p<0.001), and T13 with tetracycline resistance (p<0.01) [15].
 

Anatomical context of ANKRD11

  • We established stable 2D1-resistant variants LAC2D1R and JKT2D1R from the original SUP-T13 and Jurkat T cell lines, respectively [16].
  • In a rodent model of SCI, T13 spinal hemisection results in allodynia and hyperalgesia due in part to interruption of descending pathways, including serotonergic (5-HT) systems, that leads to hyperexcitability of dorsal horn neurons [17].
  • CONCLUSION: The dorsal portion of the L5-L6 disc of rats was shown to be multisegmentally innervated by the T13 to L6 dorsal root ganglia [18].
  • A similar disruption of the hindlimb trajectory is seen following lesions of the spinal cord at T13 that interrupt the corticospinal tract [19].
  • METHODS: CT scans of the thorax of 42 dogs without clinical or radiologic evidence of scoliosis were used to measure axial vertebral rotation from T1-T13 with a previously developed computer-based CT measurement method [20].
 

Associations of ANKRD11 with chemical compounds

  • After transection injury at either T13/L1 or L6/S1, BDNF failed to facilitate synaptic AMPA-kainate currents or agonist-induced NMDA currents [21].
  • In addition, two disulfide bonds were observed, linking the Cys residues within the T13 and T16 peptides [22].
  • There are also some conserved residues (E12, T13, K16, and N17) in all myotoxic proteins, including some neurotoxic and myotoxic PLA2s [23].
  • As to segment volume C3, T13, L2 and S1 were the most voluminous cord segments in the respective cord regions [24].
  • The longest cord segments were C2, T13, L2 and S2 segments [24].
 

Other interactions of ANKRD11

  • ANKRD11 was shown to associate with the p53 acetyltransferases and cofactors, P/CAF and hADA3 [25].
 

Analytical, diagnostic and therapeutic context of ANKRD11

  • Immunofluorescence staining reveals discrete nuclear foci of ANCO-1 that are distinct from known nuclear structures [9].
  • High performance liquid chromatography analysis of tryptic peptides derived from the mutant enzyme showed an abnormal profile with the absence of two peaks normally containing the T12 and T13 peptides and without the appearance of a supplementary peak [11].
  • To determine the mechanism for loss of surface TCR/CD3 expression, pulse-chase labeling and immunoprecipitation were performed on SUP-T13 TCR/CD3 negative cells [26].
  • Moreover, variations of the MALDI matrix preparation facilitate detection of the problematic tryptic peptides alpha T12, alpha T13, and beta T12 [27].
  • The antibodies recognize a similar but not identical epitope, as demonstrated by a competitive radioimmunoassay using 125I-labeled T11, T13, and T15 [28].

References

  1. T cell receptor expression can switch on and off at a posttranslational level. Maecker, H.T., Jokinen, D.M., Fisher, R.I. J. Immunol. (1992) [Pubmed]
  2. Localization of the discontinuous immunodominant region recognized by human anti-thyroperoxidase autoantibodies in autoimmune thyroid diseases. Bresson, D., Cerutti, M., Devauchelle, G., Pugnière, M., Roquet, F., Bes, C., Bossard, C., Chardès, T., Péraldi-Roux, S. J. Biol. Chem. (2003) [Pubmed]
  3. Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain. Liu, J., Wolfe, D., Hao, S., Huang, S., Glorioso, J.C., Mata, M., Fink, D.J. Mol. Ther. (2004) [Pubmed]
  4. A globally disseminated M1 subclone of group A streptococci differs from other subclones by 70 kilobases of prophage DNA and capacity for high-frequency intracellular invasion. Cleary, P.P., LaPenta, D., Vessela, R., Lam, H., Cue, D. Infect. Immun. (1998) [Pubmed]
  5. Mapping of translocation breakpoints on the short arm of chromosome 19 in acute leukemias by in situ hybridization. Saltman, D.L., Mellentin, J.D., Smith, S.D., Cleary, M.L. Genes Chromosomes Cancer (1990) [Pubmed]
  6. Morphology and electrophysiology of the mammalian atrioventricular node. Meijler, F.L., Janse, M.J. Physiol. Rev. (1988) [Pubmed]
  7. Variability of 11q23 rearrangements in hematopoietic cell lines identified with fluorescence in situ hybridization. Kobayashi, H., Espinosa, R., Thirman, M.J., Davis, E.M., Diaz, M.O., Le Beau, M.M., Rowley, J.D. Blood (1993) [Pubmed]
  8. Tumor necrosis factor-alpha contributes to below-level neuropathic pain after spinal cord injury. Peng, X.M., Zhou, Z.G., Glorioso, J.C., Fink, D.J., Mata, M. Ann. Neurol. (2006) [Pubmed]
  9. Identification of a novel family of ankyrin repeats containing cofactors for p160 nuclear receptor coactivators. Zhang, A., Yeung, P.L., Li, C.W., Tsai, S.C., Dinh, G.K., Wu, X., Li, H., Chen, J.D. J. Biol. Chem. (2004) [Pubmed]
  10. Changes in serotonin, serotonin transporter expression and serotonin denervation supersensitivity: involvement in chronic central pain after spinal hemisection in the rat. Hains, B.C., Everhart, A.W., Fullwood, S.D., Hulsebosch, C.E. Exp. Neurol. (2002) [Pubmed]
  11. Isolation, characterization, and structure of a mutant 89 Arg----Cys bisphosphoglycerate mutase. Implication of the active site in the mutation. Rosa, R., Blouquit, Y., Calvin, M.C., Prome, D., Prome, J.C., Rosa, J. J. Biol. Chem. (1989) [Pubmed]
  12. Comparison of apoptosis signaling through T cell receptor, fas, and calcium ionophore. Maecker, H.T., Hedjbeli, S., Alzona, M., Le, P.T. Exp. Cell Res. (1996) [Pubmed]
  13. DNA fragmentation and cell death mediated by T cell antigen receptor/CD3 complex on a leukemia T cell line. Takahashi, S., Maecker, H.T., Levy, R. Eur. J. Immunol. (1989) [Pubmed]
  14. The solution conformations of a mutant trp operator determined by n.m.r. spectroscopy. Lane, A.N. Biochem. J. (1991) [Pubmed]
  15. Streptococcus pyogenes isolated in Portugal: macrolide resistance phenotypes and correlation with T types. Portuguese Surveillance Group for the Study of Respiratory Pathogens. Melo-Cristino, J., Fernandes, M.L. Microb. Drug Resist. (1999) [Pubmed]
  16. Establishment of apoptosis-inducing monoclonal antibody 2D1 and 2D1-resistant variants of human T cell lines. Takahashi, S., Sato, N., Takayama, S., Ichimiya, S., Satoh, M., Hyakumachi, N., Kikuchi, K. Eur. J. Immunol. (1993) [Pubmed]
  17. Serotonin receptors 5-HT1A and 5-HT3 reduce hyperexcitability of dorsal horn neurons after chronic spinal cord hemisection injury in rat. Hains, B.C., Willis, W.D., Hulsebosch, C.E. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (2003) [Pubmed]
  18. Sensory innervation of the dorsal portion of the lumbar intervertebral disc in rats. Ohtori, S., Takahashi, Y., Takahashi, K., Yamagata, M., Chiba, T., Tanaka, K., Hirayama, J., Moriya, H. Spine. (1999) [Pubmed]
  19. Role of the motor cortex in the control of visually triggered gait modifications. Drew, T., Jiang, W., Kably, B., Lavoie, S. Can. J. Physiol. Pharmacol. (1996) [Pubmed]
  20. Analysis of preexistent vertebral rotation in the normal quadruped spine. Kouwenhoven, J.W., Vincken, K.L., Bartels, L.W., Meij, B.P., Oner, F.C., Castelein, R.M. Spine (2006) [Pubmed]
  21. Spinal Cord Transection Enhances Afferent-Evoked Inhibition in Lamina II Neurons And Abolishes BDNF-Induced Facilitation of Their Sensory Input. Garraway, S.M., Mendell, L.M. J. Neurotrauma (2007) [Pubmed]
  22. Post-translational modifications of recombinant B. cinerea EPG 6. Xie, M., Krooshof, G.H., Benen, J.A., Atwood, J.A., King, D., Bergmann, C., Orlando, R. Rapid Commun. Mass Spectrom. (2005) [Pubmed]
  23. cDNA cloning and sequence analysis of a lysine-49 phospholipase A2 myotoxin from Agkistrodon contortrix laticinctus snake venom. Selistre de Araujo, H.S., White, S.P., Ownby, C.L. Arch. Biochem. Biophys. (1996) [Pubmed]
  24. Anatomical studies on the spinal cord segments of the impala (Aepyceros melampus). Rao, G.S., Kalt, D.J., Koch, M., Majok, A.A. Anatomia, histologia, embryologia. (1993) [Pubmed]
  25. Identification of ANKRD11 as a p53 coactivator. Neilsen, P.M., Cheney, K.M., Li, C.W., Chen, J.D., Cawrse, J.E., Schulz, R.B., Powell, J.A., Kumar, R., Callen, D.F. J. Cell. Sci. (2008) [Pubmed]
  26. A reversible defect in alpha-beta T cell receptor assembly. Maecker, H., Thomas, J.T., Consorti, R.L., Ellis, T.M. Exp. Cell Res. (1996) [Pubmed]
  27. Toward a simple, expedient, and complete analysis of human hemoglobin by MALDI-TOFMS. Houston, C.T., Reilly, J.P. Anal. Chem. (1999) [Pubmed]
  28. Leishmania tropica: characterization of a lipophosphoglycan-like antigen recognized by species-specific monoclonal antibodies. Jaffe, C.L., Pérez, M.L., Sarfstein, R. Exp. Parasitol. (1990) [Pubmed]
 
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