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Gene Review

Dync1h1  -  dynein cytoplasmic 1 heavy chain 1

Rattus norvegicus

Synonyms: Cytoplasmic dynein 1 heavy chain 1, Cytoplasmic dynein heavy chain 1, Dhc1, Dnch1, Dnchc1, ...
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Disease relevance of Dync1h1


High impact information on Dync1h1

  • The N-terminal third of the two polypeptides shows no clear relationship, suggesting that this region of MAP 1C is responsible for its association with retrograde organelles and other functions [3].
  • Thus, in contrast with cilia and flagella, which contain numerous forms of dynein, our results are consistent with the existence of only a single cytoplasmic dynein heavy chain gene, which appears to produce only a single transcript [3].
  • HMW-2 was selectively released from testis microtubules by ATP and co-purified by sucrose density gradient centrifugation with MAP-1C, a neuronal cytoplasmic dynein [4].
  • We found that MAP 1 can be resolved by SDS PAGE into three electrophoretic bands, which we have designated MAP 1A, MAP 1B, and MAP 1C in order of increasing electrophoretic mobility [5].
  • Another interesting feature of this 1,25-D3 induced-cell death program is the down-regulated expression of transcripts for the microtubule motor dynein heavy chain/MAP 1C and of the calcium-binding S100beta protein [6].

Biological context of Dync1h1


Anatomical context of Dync1h1


Associations of Dync1h1 with chemical compounds

  • Synthesis and biological evaluation of purealin and analogues as cytoplasmic dynein heavy chain inhibitors [10].
  • A significant reduction in the serum markers of heart and kidney damage and the extent of lipid peroxidation with a concomitant increase in the enzymatic (SOD and CAT) and non-enzymatic antioxidants (reduced glutathione) were observed in DHC-1 pretreated animals compared with the isoproterenol or cisplatin alone treated animals [2].

Other interactions of Dync1h1

  • A microtubule associated protein from brain tissue (MAP 1C), has been found to possess many properties in common with ciliary and flagellar dyneins (Paschal et al.:J. Cell Biol. 105:1273-1282, 1987) [12].

Analytical, diagnostic and therapeutic context of Dync1h1

  • Molecular cloning of the retrograde transport motor cytoplasmic dynein (MAP 1C) [3].
  • In this report, we demonstrate the localization of cytoplasmic dynein and manchette development by a double immunofluorescence technique using anti-bovine brain MAP 1C and anti-tubulin [13].


  1. Anti-ulcer and antioxidant activity of DHC-1, a herbal formulation. Bafna, P.A., Balaraman, R. Journal of ethnopharmacology. (2004) [Pubmed]
  2. Antioxidant activity of DHC-1, an herbal formulation, in experimentally-induced cardiac and renal damage. Bafna, P.A., Balaraman, R. Phytotherapy research : PTR. (2005) [Pubmed]
  3. Molecular cloning of the retrograde transport motor cytoplasmic dynein (MAP 1C). Mikami, A., Paschal, B.M., Mazumdar, M., Vallee, R.B. Neuron (1993) [Pubmed]
  4. Sertoli cell processes have axoplasmic features: an ordered microtubule distribution and an abundant high molecular weight microtubule-associated protein (cytoplasmic dynein). Neely, M.D., Boekelheide, K. J. Cell Biol. (1988) [Pubmed]
  5. Widespread distribution of the major polypeptide component of MAP 1 (microtubule-associated protein 1) in the nervous system. Bloom, G.S., Schoenfeld, T.A., Vallee, R.B. J. Cell Biol. (1984) [Pubmed]
  6. Differentially expressed genes in C6.9 glioma cells during vitamin D-induced cell death program. Baudet, C., Perret, E., Delpech, B., Kaghad, M., Brachet, P., Wion, D., Caput, D. Cell Death Differ. (1998) [Pubmed]
  7. Distinct but overlapping sites within the cytoplasmic dynein heavy chain for dimerization and for intermediate chain and light intermediate chain binding. Tynan, S.H., Gee, M.A., Vallee, R.B. J. Biol. Chem. (2000) [Pubmed]
  8. Identification of seven rat axonemal dynein heavy chain genes: expression during ciliated cell differentiation. Andrews, K.L., Nettesheim, P., Asai, D.J., Ostrowski, L.E. Mol. Biol. Cell (1996) [Pubmed]
  9. Identification and molecular evolution of new dynein-like protein sequences in rat brain. Tanaka, Y., Zhang, Z., Hirokawa, N. J. Cell. Sci. (1995) [Pubmed]
  10. Synthesis and biological evaluation of purealin and analogues as cytoplasmic dynein heavy chain inhibitors. Zhu, G., Yang, F., Balachandran, R., Höök, P., Vallee, R.B., Curran, D.P., Day, B.W. J. Med. Chem. (2006) [Pubmed]
  11. A novel cytoplasmic dynein heavy chain: expression of DHC1b in mammalian ciliated epithelial cells. Criswell, P.S., Ostrowski, L.E., Asai, D.J. J. Cell. Sci. (1996) [Pubmed]
  12. Preparation of microtubules from rat liver and testis: cytoplasmic dynein is a major microtubule associated protein. Collins, C.A., Vallee, R.B. Cell Motil. Cytoskeleton (1989) [Pubmed]
  13. Association of cytoplasmic dynein with manchette microtubules and spermatid nuclear envelope during spermiogenesis in rats. Yoshida, T., Ioshii, S.O., Imanaka-Yoshida, K., Izutsu, K. J. Cell. Sci. (1994) [Pubmed]
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