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Gene Review

Dync1h1  -  dynein cytoplasmic 1 heavy chain 1

Mus musculus

Synonyms: 9930018I23Rik, AI894280, Cytoplasmic dynein 1 heavy chain 1, Cytoplasmic dynein heavy chain 1, DHC1, ...
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Disease relevance of Dync1h1

  • The polypeptide, designated P31, is composed of the major polypeptide of hepatitis B surface antigen (P22) and an additional, as yet unidentified, amino acid sequence [1].
  • We present validation studies of SR-4554 as a noninvasive hypoxia marker detected by fluorine-19 magnetic resonance spectroscopy ((19)F MRS) in the P22 carcinosarcoma, a tumor with clinically relevant hypoxia levels [2].
  • Interestingly, hybridization of an orgA gene probe with a P22 chromosomal mapping library demonstrated that the orgA gene maps to a region on the chromosome between 57.5 and 60 min where other Salmonella invasion genes have been mapped [3].
  • By a series of P22 transductions, the fkpA gene of S. typhimurium Copenhagen was replaced with the inactive fkpA1::omega-Cm gene from Escherichia coli, creating the mutant S. typhimurium KY32H1 [4].
  • Immunoreactivity gradually disappeared from the OHCs starting at P10 and, at P22, only IHCs and ganglion neurons were positive [5].

High impact information on Dync1h1

  • Replacement of the mviA allele of strain WB600 using P22 transductions of linked antibiotic cassettes cloned into the chromosome of virulent S. typhimurium strains (SR-11, TML, SL1344, C5, ATCC14028, W118-2, and WB600) showed that all but WB600 contained the avirulent mviA+ allele [6].
  • However, molecules other than cDHC might mediate attachment of the Golgi complex and endosomes/lysosomes to microtubules [7].
  • These results show that cDHC is essential for the formation and positioning of the Golgi complex [7].
  • To elucidate the function of cytoplasmic dynein, we have produced mice lacking cDHC by gene targeting. cDHC-/- embryos were indistinguishable from cDHC+/-or cDHC+/+ littermates at the blastocyst stage [7].
  • Brain dynein (MAP1C) localizes on both anterogradely and retrogradely transported membranous organelles in vivo [8].

Biological context of Dync1h1


Anatomical context of Dync1h1

  • Subsequently, between P7 and P22, regional differences characteristic of mature hippocampus appeared-intense labeling of neurons in CA3 and CA1, and less in CA2 [13].
  • In addition, expression of both cathepsin K and TRAP is increased significantly in osteoclasts cotransfected with Nox4/P22 [14].

Associations of Dync1h1 with chemical compounds

  • (i) P22 synthesis is induced by putrescine but not cadaverine [15].
  • We found that the NMDA PPR increased gradually (thus, a reduction in Pr) from postnatal day (P)4 to P22 but, unexpectedly, the AMPA PPR exhibited a simultaneous decrease [16].
  • To define mechanisms, bromodeoxyuridine (BrdU) was injected at P1 and mitotically labelled cells were assessed at P22: there was a twofold increase in BrdU-positive cells in the dentate granule cell layer (GCL), indicating that bFGF enhanced the generation of neurons, or neuronogenesis, from a cohort of precursors [17].

Analytical, diagnostic and therapeutic context of Dync1h1


  1. A polypeptide containing 55 amino acid residues coded by the pre-S region of hepatitis B virus deoxyribonucleic acid bears the receptor for polymerized human as well as chimpanzee albumins. Machida, A., Kishimoto, S., Ohnuma, H., Baba, K., Ito, Y., Miyamoto, H., Funatsu, G., Oda, K., Usuda, S., Togami, S. Gastroenterology (1984) [Pubmed]
  2. Validation of the fluorinated 2-nitroimidazole SR-4554 as a noninvasive hypoxia marker detected by magnetic resonance spectroscopy. Seddon, B.M., Maxwell, R.J., Honess, D.J., Grimshaw, R., Raynaud, F., Tozer, G.M., Workman, P. Clin. Cancer Res. (2002) [Pubmed]
  3. Identification and characterization of a Salmonella typhimurium oxygen-regulated gene required for bacterial internalization. Jones, B.D., Falkow, S. Infect. Immun. (1994) [Pubmed]
  4. Decreased intracellular survival of an fkpA mutant of Salmonella typhimurium Copenhagen. Horne, S.M., Kottom, T.J., Nolan, L.K., Young, K.D. Infect. Immun. (1997) [Pubmed]
  5. Development of calretinin immunoreactivity in the mouse inner ear. Dechesne, C.J., Rabejac, D., Desmadryl, G. J. Comp. Neurol. (1994) [Pubmed]
  6. The Salmonella typhimurium locus mviA regulates virulence in Itys but not Ityr mice: functional mviA results in avirulence; mutant (nonfunctional) mviA results in virulence. Benjamin, W.H., Yother, J., Hall, P., Briles, D.E. J. Exp. Med. (1991) [Pubmed]
  7. Golgi vesiculation and lysosome dispersion in cells lacking cytoplasmic dynein. Harada, A., Takei, Y., Kanai, Y., Tanaka, Y., Nonaka, S., Hirokawa, N. J. Cell Biol. (1998) [Pubmed]
  8. Brain dynein (MAP1C) localizes on both anterogradely and retrogradely transported membranous organelles in vivo. Hirokawa, N., Sato-Yoshitake, R., Yoshida, T., Kawashima, T. J. Cell Biol. (1990) [Pubmed]
  9. High-resolution map and imprinting analysis of the Gtl2-Dnchc1 domain on mouse chromosome 12. Tierling, S., Dalbert, S., Schoppenhorst, S., Tsai, C.E., Oliger, S., Ferguson-Smith, A.C., Paulsen, M., Walter, J. Genomics (2006) [Pubmed]
  10. Prion disease incubation time is not affected in mice heterozygous for a dynein mutation. Hafezparast, M., Brandner, S., Linehan, J., Martin, J.E., Collinge, J., Fisher, E.M. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  11. Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Hafezparast, M., Klocke, R., Ruhrberg, C., Marquardt, A., Ahmad-Annuar, A., Bowen, S., Lalli, G., Witherden, A.S., Hummerich, H., Nicholson, S., Morgan, P.J., Oozageer, R., Priestley, J.V., Averill, S., King, V.R., Ball, S., Peters, J., Toda, T., Yamamoto, A., Hiraoka, Y., Augustin, M., Korthaus, D., Wattler, S., Wabnitz, P., Dickneite, C., Lampel, S., Boehme, F., Peraus, G., Popp, A., Rudelius, M., Schlegel, J., Fuchs, H., Hrabe de Angelis, M., Schiavo, G., Shima, D.T., Russ, A.P., Stumm, G., Martin, J.E., Fisher, E.M. Science (2003) [Pubmed]
  12. Cytoplasmic dynein intermediate chain and heavy chain are dependent upon each other for microtubule end localization in Aspergillus nidulans. Zhang, J., Han, G., Xiang, X. Mol. Microbiol. (2002) [Pubmed]
  13. Mouse brain potassium channel beta1 subunit mRNA: cloning and distribution during development. Butler, D.M., Ono, J.K., Chang, T., McCaman, R.E., Barish, M.E. J. Neurobiol. (1998) [Pubmed]
  14. Expression of Nox4 in osteoclasts. Yang, S., Zhang, Y., Ries, W., Key, L. J. Cell. Biochem. (2004) [Pubmed]
  15. Characterization of a counterpart to Mammalian ornithine decarboxylase antizyme in prokaryotes. Yamaguchi, Y., Takatsuka, Y., Matsufuji, S., Murakami, Y., Kamio, Y. J. Biol. Chem. (2006) [Pubmed]
  16. Transiently higher release probability during critical period at thalamocortical synapses in the mouse barrel cortex: relevance to differential short-term plasticity of AMPA and NMDA EPSCs and possible involvement of silent synapses. Yanagisawa, T., Tsumoto, T., Kimura, F. Eur. J. Neurosci. (2004) [Pubmed]
  17. Hippocampal granule neuron production and population size are regulated by levels of bFGF. Cheng, Y., Black, I.B., DiCicco-Bloom, E. Eur. J. Neurosci. (2002) [Pubmed]
  18. Specific and cross-reacting antibodies in human responses to Onchocerca volvulus and Dracunculus medinensis infections. Garate, T., Kliks, M.M., Cabrera, Z., Parkhouse, R.M. Am. J. Trop. Med. Hyg. (1990) [Pubmed]
  19. The role of nitric oxide in development of the patch-cluster system and retinocollicular pathways in the rodent superior colliculus. Mize, R.R., Wu, H.H., Cork, R.J., Scheiner, C.A. Prog. Brain Res. (1998) [Pubmed]
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