The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Tgfbr3  -  transforming growth factor, beta receptor III

Rattus norvegicus

Synonyms: Betaglycan, TGF-beta receptor type 3, TGF-beta receptor type III, TGFR-3, Transforming growth factor beta receptor III, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tgfbr3

  • During the transformation of fat-storing cells into myofibroblasts (the key process in the development of liver cirrhosis), the levels of mRNA for syndecan-1, -3, and -4 remain constant, whereas the amount of syndecan-2 mRNA increases and that for betaglycan decreases [1].

High impact information on Tgfbr3


Biological context of Tgfbr3

  • In general, betaglycan immunoreactivity was present in the anterior pituitary at all estrous cycle time points, but was confined to the membrane of gonadotropes just before and after the primary and secondary FSH surges [6].
  • In ovarian regulatory function, the expression of betaglycan may involve the functional antagonism of inhibin A in activin signal transduction [5].
  • The increase of betaglycan mRNA was due to an increase in transcription and altered mRNA stability [5].
  • Betaglycan was reported by our laboratory to serve as an inhibin binding protein and to facilitate the antagonism of activin signaling [7].
  • Expression of betaglycan and type II receptors decline relative to type I receptor expression in parallel with an increase in osteoblast-like activity, predicting that the ratio among various TGF-beta binding sites could influence how its signals are perceived [2].

Anatomical context of Tgfbr3


Associations of Tgfbr3 with chemical compounds


Other interactions of Tgfbr3


Analytical, diagnostic and therapeutic context of Tgfbr3


  1. Gene expression of syndecans and betaglycan in isolated rat liver cells. Weiner, O.H., Zoremba, M., Gressner, A.M. Cell Tissue Res. (1996) [Pubmed]
  2. Independent changes in type I and type II receptors for transforming growth factor beta induced by bone morphogenetic protein 2 parallel expression of the osteoblast phenotype. Centrella, M., Casinghino, S., Kim, J., Pham, T., Rosen, V., Wozney, J., McCarthy, T.L. Mol. Cell. Biol. (1995) [Pubmed]
  3. Role of endoglin in cellular responses to transforming growth factor-beta. A comparative study with betaglycan. Letamendía, A., Lastres, P., Botella, L.M., Raab, U., Langa, C., Velasco, B., Attisano, L., Bernabeu, C. J. Biol. Chem. (1998) [Pubmed]
  4. Amino acid determinants that drive heparan sulfate assembly in a proteoglycan. Zhang, L., Esko, J.D. J. Biol. Chem. (1994) [Pubmed]
  5. Effect of follicle-stimulating hormone and estrogen on the expression of betaglycan messenger ribonucleic acid levels in cultured rat granulosa cells. Omori, Y., Nakamura, K., Yamashita, S., Matsuda, H., Mizutani, T., Miyamoto, K., Minegishi, T. Endocrinology (2005) [Pubmed]
  6. Betaglycan localization in the female rat pituitary: implications for the regulation of follicle-stimulating hormone by inhibin. Chapman, S.C., Woodruff, T.K. Endocrinology (2003) [Pubmed]
  7. The distribution of betaglycan protein and mRNA in rat brain, pituitary, and gonads: implications for a role for betaglycan in inhibin-mediated reproductive functions. MacConell, L.A., Leal, A.M., Vale, W.W. Endocrinology (2002) [Pubmed]
  8. Modulation of transforming growth factor beta receptors of rat lipocytes during the hepatic wound healing response. Enhanced binding and reduced gene expression accompany cellular activation in culture and in vivo. Friedman, S.L., Yamasaki, G., Wong, L. J. Biol. Chem. (1994) [Pubmed]
  9. Expression and distribution of cell-surface proteoglycans in the normal Lewis rat molar periodontium. Worapamorn, W., Li, H., Pujic, Z., Xiao, Y., Young, W.G., Bartold, P.M. J. Periodont. Res. (2000) [Pubmed]
  10. Extracellular matrix modulates expression of cell-surface proteoglycan genes in fibroblasts. Sawaguchi, N., Majima, T., Iwasaki, N., Funakoshi, T., Shimode, K., Onodera, T., Minami, A. Connect. Tissue Res. (2006) [Pubmed]
  11. Identification of soluble transforming growth factor-beta receptor III (sTbetaIII) in rat milk. Zhang, M., Zola, H., Read, L., Penttila, I. Immunol. Cell Biol. (2001) [Pubmed]
WikiGenes - Universities