Disease relevance of Tgfbr3

• During the transformation of fat-storing cells into myofibroblasts (the key process in the development of liver cirrhosis), the levels of mRNA for syndecan-1, -3, and -4 remain constant, whereas the amount of syndecan-2 mRNA increases and that for betaglycan decreases [1].

High impact information on Tgfbr3

• In contrast, BMP-2 rapidly reduces TGF-beta binding to betaglycan and type II receptors in osteoblast-enriched primary cell cultures and increases its relative binding to type I receptors in these cells and in ROS 17/2.8 cultures [2].
• These findings suggest a role for endoglin in TGF-beta responses distinct from that of betaglycan [3].
• It shares with betaglycan a limited amino acid sequence homology and being components of the membrane transforming growth factor-beta (TGF-beta) receptor complex [3].
• More importantly, introducing tryptophan next to three different Ser-Gly dipeptides in betaglycan and syndecan-1 chimeras stimulated assembly of heparan sulfate [4].
• Furthermore, betaglycan mRNA was induced additively by estradiol, which was blocked by estrogen receptor antagonists [ICI 182780, (R, R)-cis-diethyltetrahydro-2,8-chrysenediol] [5].

Biological context of Tgfbr3

• In general, betaglycan immunoreactivity was present in the anterior pituitary at all estrous cycle time points, but was confined to the membrane of gonadotropes just before and after the primary and secondary FSH surges [6].
• In ovarian regulatory function, the expression of betaglycan may involve the functional antagonism of inhibin A in activin signal transduction [5].
• The increase of betaglycan mRNA was due to an increase in transcription and altered mRNA stability [5].
• Betaglycan was reported by our laboratory to serve as an inhibin binding protein and to facilitate the antagonism of activin signaling [7].
• Expression of betaglycan and type II receptors decline relative to type I receptor expression in parallel with an increase in osteoblast-like activity, predicting that the ratio among various TGF-beta binding sites could influence how its signals are perceived [2].

Anatomical context of Tgfbr3

• The present study was undertaken to identify the expression and the regulation of the betaglycan gene in cultured rat granulosa cells [5].
• In the gonads, betaglycan mRNA was localized in cellular compartments, coinciding with its protein for the most part [7].
• In the testes, betaglycan mRNA was observed in the Leydig and tubule-specific germ cells [7].
• In the brain, betaglycan mRNA is localized in discrete regions of the forebrain and brain stem, including olfactory, septal, and hypothalamic nuclei [7].
• Isolated lipocytes were maintained in a quiescent state by culturing the cells in suspension, where they displayed minimal specific binding for TGF-beta 1 and only a small amount of type III (betaglycan) receptor by affinity labeling [8].

Associations of Tgfbr3 with chemical compounds

• Effect of follicle-stimulating hormone and estrogen on the expression of betaglycan messenger ribonucleic acid levels in cultured rat granulosa cells [5].

Other interactions of Tgfbr3

• In summary, FSH and estradiol increased betaglycan mRNA expression, most possibly through the protein kinase A pathway and the estrogen receptor-beta [5].
• To understand better the expression and distribution of cell-surface proteoglycans in the periodontal tissues, an immunohistochemical evaluation of the normal Lewis rat molar periodontium using panels of antibodies for syndecan-1, -2, -4, glypican and betaglycan was carried out [9].
• This study investigated the regulation by the ECM of the expression of cell-surface proteoglycans (CD44, syndecan-1-4, betaglycan, glypican-1) [10].
• Role of endoglin in cellular responses to transforming growth factor-beta. A comparative study with betaglycan [3].
• TbetaRIII (or betaglycan) has been reported in serum, cell culture medium and extracellular matrix [11].

Analytical, diagnostic and therapeutic context of Tgfbr3

• Northern blot analysis indicated betaglycan mRNA transcript of approximately 6.4 kbp [5].

References