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Gene Review

Eng  -  endoglin

Rattus norvegicus

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Disease relevance of Eng


High impact information on Eng


Biological context of Eng


Anatomical context of Eng


Associations of Eng with chemical compounds


Regulatory relationships of Eng

  • Ang II-induced decrease in MMP-1 protein expression and increase in type I collagen protein expression were both blocked by a specific endoglin antibody [8].

Other interactions of Eng


Analytical, diagnostic and therapeutic context of Eng


  1. Soluble endoglin contributes to the pathogenesis of preeclampsia. Venkatesha, S., Toporsian, M., Lam, C., Hanai, J., Mammoto, T., Kim, Y.M., Bdolah, Y., Lim, K.H., Yuan, H.T., Libermann, T.A., Stillman, I.E., Roberts, D., D'Amore, P.A., Epstein, F.H., Sellke, F.W., Romero, R., Sukhatme, V.P., Letarte, M., Karumanchi, S.A. Nat. Med. (2006) [Pubmed]
  2. Role of endoglin in cellular responses to transforming growth factor-beta. A comparative study with betaglycan. Letamendía, A., Lastres, P., Botella, L.M., Raab, U., Langa, C., Velasco, B., Attisano, L., Bernabeu, C. J. Biol. Chem. (1998) [Pubmed]
  3. Up-regulation of endoglin, a TGF-beta-binding protein, in rats with experimental renal fibrosis induced by renal mass reduction. Rodríguez-Peña, A., Prieto, M., Duwel, A., Rivas, J.V., Eleno, N., Pérez-Barriocanal, F., Arévalo, M., Smith, J.D., Vary, C.P., Bernabeu, C., López-Novoa, J.M. Nephrol. Dial. Transplant. (2001) [Pubmed]
  4. Temporal changes in renal endoglin and TGF-beta1 expression following ureteral obstruction in rats. Prieto, M., Rodríguez-Peña, A.B., Düwel, A., Rivas, J.V., Docherty, N., Pérez-Barriocanal, F., Arévalo, M., Vary, C.P., Bernabeu, C., López-Novoa, J.M., Eleno, N. Journal of physiology and biochemistry. (2005) [Pubmed]
  5. Identification of endoglin in rat hepatic stellate cells: new insights into transforming growth factor beta receptor signaling. Meurer, S.K., Tihaa, L., Lahme, B., Gressner, A.M., Weiskirchen, R. J. Biol. Chem. (2005) [Pubmed]
  6. Endoglin regulates cytoskeletal organization through binding to ZRP-1, a member of the Lim family of proteins. Sanz-Rodriguez, F., Guerrero-Esteo, M., Botella, L.M., Banville, D., Vary, C.P., Bernabéu, C. J. Biol. Chem. (2004) [Pubmed]
  7. Improved free vascular graft survival in an irradiated surgical site following topical application of rVEGF. Schultze-Mosgau, S., Wehrhan, F., Rödel, F., Amann, K., Radespiel-Tröger, M., Grabenbauer, G.G. Int. J. Radiat. Oncol. Biol. Phys. (2003) [Pubmed]
  8. Transforming growth factor beta receptor endoglin is expressed in cardiac fibroblasts and modulates profibrogenic actions of angiotensin II. Chen, K., Mehta, J.L., Li, D., Joseph, L., Joseph, J. Circ. Res. (2004) [Pubmed]
  9. Lumican is down-regulated in cells expressing endoglin. Evidence for an inverse correlationship between Endoglin and Lumican expression. Botella, L.M., Sanz-Rodriguez, F., Sanchez-Elsner, T., Langa, C., Ramirez, J.R., Vary, C., Roughley, P.J., Bernabeu, C. Matrix Biol. (2004) [Pubmed]
  10. Endoglin expression in human and rat mesangial cells and its upregulation by TGF-beta1. Rodríguez-Barbero, A., Obreo, J., Eleno, N., Rodríguez-Peña, A., Düwel, A., Jerkic, M., Sánchez-Rodríguez, A., Bernabéu, C., López-Novoa, J.M. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  11. Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy. Risbud, M.V., Albert, T.J., Guttapalli, A., Vresilovic, E.J., Hillibrand, A.S., Vaccaro, A.R., Shapiro, I.M. Spine. (2004) [Pubmed]
  12. Endoglin expression regulates basal and TGF-beta1-induced extracellular matrix synthesis in cultured L6E9 myoblasts. Obreo, J., Díez-Marques, L., Lamas, S., Düwell, A., Eleno, N., Bernabéu, C., Pandiella, A., López-Novoa, J.M., Rodríguez-Barbero, A. Cell. Physiol. Biochem. (2004) [Pubmed]
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