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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

West Indies

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Disease relevance of West Indies


High impact information on West Indies

  • Here we report observations of BrO and SO2 abundances in the plume of the Soufrière Hills volcano (Montserrat) in May 2002 by ground-based multi-axis differential optical absorption spectroscopy [6].
  • A single-base-pair deletion in exon 7 of the human carbonic anhydrase II gene was found to be the molecular defect in a group of independently ascertained, clinically heterogeneous, Hispanic carbonic anhydrase II-deficient patients, all of whom had ancestors from the Caribbean islands [7].
  • Nineteen of the 30 infected patients were parenteral drug abusers, 10 were from Caribbean Islands and had no identified risk factor, and one was a homosexual male [8].
  • Freely foraging ARGIOPE: argentata (Araneae: Araneoidea), collected from 13 Caribbean islands, produced dragline silk that showed an inverse relationship between the amount of serine and glycine they contained [9].
  • Low relative prevalence of IDDM in French West Indies [10].

Chemical compound and disease context of West Indies


Biological context of West Indies


Associations of West Indies with chemical compounds

  • A new case of a defect in red cell pyrimidine 5'-nucleotide (P5N) activity was found in a large family from Guadeloupe in the West Indies [15].
  • Effects of irrigation on appearance and survival of infective larvae of goat gastro-intestinal nematodes in Guadeloupe (French West Indies) [16].
  • They have also colonized groups of Atlantic islands five times: a single invasion of the West Indies and three of the Canary islands, one of which then went on to invade the Cape Verde archipelago [17].
  • More than 400 faecal samples (from normal and malnourished children, and from mixed-age participants in a field survey of the Turks and Caicos Islands) were each mixed with 2-5 mg of sodium azide powder and stored in 2 or 4 ml autoanalyser cups at ambient tropical temperature [18].
  • The outcome is described of 48 entrants to a postgraduate degree course (DM) in Internal Medicine established at the University of the West Indies in 1974 [19].

Gene context of West Indies

  • RESULTS: We identified a homozygous 4-base-pair insertion in exon 5 of SPINK5, which introduces a premature termination codon and appears to be a common mutation among West Indies islanders [20].
  • In a new approach to these features, we sequenced the entire env gene of 65 HTLV-I isolates originating from Gabon, French Guiana, West Indies, and Iran, such isolates representing all major HTLVI phylums but the Australo-Melanesian one [21].
  • Allelic frequency variations at the MDH-1 locus within Schistosoma mansoni strains from Guadeloupe (French West Indies): ecological interpretation [22].
  • Two predominant types recognized by pulsed-field gel electrophoresis (PFGE) accounted for the majority of the GS-MRSA in different mainland hospitals, both differing from the predominant type observed in the French West Indies [23].
  • A series of 171 blacks from Trinidad, West Indies, was studied with respect to haemoglobin types, serum protein systems (Tf and Gc subtypes) and red cell enzyme types (AcPh, 6-PGD, AK, EsD, GLO and PGM1) [24].

Analytical, diagnostic and therapeutic context of West Indies


  1. A historical study of human T lymphotropic virus type I transmission in Barbados. Riedel, D.A., Evans, A.S., Saxinger, C., Blattner, W.A. J. Infect. Dis. (1989) [Pubmed]
  2. Effect of hypoglycin A on insulin release. Mills, J., Melville, G.N., Bennett, C., West, M., Castro, A. Biochem. Pharmacol. (1987) [Pubmed]
  3. Intramyometrial vasopressin as a haemostatic agent during myomectomy. Frederick, J., Fletcher, H., Simeon, D., Mullings, A., Hardie, M. British journal of obstetrics and gynaecology. (1994) [Pubmed]
  4. Ciguatera fish poisoning in the Caribbean islands and Western Atlantic. Pottier, I., Vernoux, J.P., Lewis, R.J. Reviews of environmental contamination and toxicology. (2001) [Pubmed]
  5. Microalbuminuria, renal function and waist:hip ratio in black hypertensive Jamaicans. Reid, M., Bennett, F., Wilks, R., Forrester, T. Journal of human hypertension. (1998) [Pubmed]
  6. Detection of bromine monoxide in a volcanic plume. Bobrowski, N., Hönninger, G., Galle, B., Platt, U. Nature (2003) [Pubmed]
  7. Partial rescue of human carbonic anhydrase II frameshift mutation by ribosomal frameshift. Hu, P.Y., Waheed, A., Sly, W.S. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  8. Bacterial infections in adult patients with the acquired immune deficiency syndrome (AIDS) and AIDS-related complex. Witt, D.J., Craven, D.E., McCabe, W.R. Am. J. Med. (1987) [Pubmed]
  9. Evidence for diet effects on the composition of silk proteins produced by spiders. Craig, C.L., Riekel, C., Herberstein, M.E., Weber, R.S., Kaplan, D., Pierce, N.E. Mol. Biol. Evol. (2000) [Pubmed]
  10. Low relative prevalence of IDDM in French West Indies. Moutet, J.P., Kangambega, P.F., Pileire, B.D., Donnet, J.P. Diabetes Care (1989) [Pubmed]
  11. Cerasee, a traditional treatment for diabetes. Studies in normal and streptozotocin diabetic mice. Bailey, C.J., Day, C., Turner, S.L., Leatherdale, B.A. Diabetes Res. (1985) [Pubmed]
  12. Population structure among African and derived populations of Drosophila simulans: evidence for ancient subdivision and recent admixture. Hamblin, M.T., Veuille, M. Genetics (1999) [Pubmed]
  13. Intestinal parasites among young children in the interior of Guyana. Lindo, J.F., Validum, L., Ager, A.L., Campa, A., Cuadrado, R.R., Cummings, R., Palmer, C.J. The West Indian medical journal. (2002) [Pubmed]
  14. Epidemiology of vitiligo in the French West Indies (Isle of Martinique). Boisseau-Garsaud, A.M., Garsaud, P., Calès-Quist, D., Hélénon, R., Quénéhervé, C., Claire, R.C. International journal of dermatology. (2000) [Pubmed]
  15. Electrophoretic and kinetic studies of human erythrocytes deficient in pyrimidine 5'-nucleotidase. Rosa, R., Rochant, H., Dreyfus, B., Valentin, C., Rosa, J. Hum. Genet. (1977) [Pubmed]
  16. Effects of irrigation on appearance and survival of infective larvae of goat gastro-intestinal nematodes in Guadeloupe (French West Indies). Gruner, L., Berbigier, P., Cortet, J., Sauve, C. Int. J. Parasitol. (1989) [Pubmed]
  17. Relationships and evolution of the North African geckos, Geckonia and Tarentola (Reptilia: Gekkonidae), based on mitochondrial and nuclear DNA sequences. Carranza, S., Arnold, E.N., Mateo, J.A., Geniez, P. Mol. Phylogenet. Evol. (2002) [Pubmed]
  18. Sodium azide preservation of faecal specimens for Kato analysis. Bundy, D.A., Foreman, J.D., Golden, M.H. Parasitology (1985) [Pubmed]
  19. An assessment of the doctorate of medicine (internal medicine), University of the West Indies. Terry, S.I., Morgan, O.S. Medical education. (1989) [Pubmed]
  20. Netherton syndrome with extensive skin peeling and failure to thrive due to a homozygous frameshift mutation in SPINK5. Geyer, A.S., Ratajczak, P., Pol-Rodriguez, M., Millar, W.S., Garzon, M., Richard, G. Dermatology (Basel) (2005) [Pubmed]
  21. New insights in HTLV-I phylogeny by sequencing and analyzing the entire envelope gene. Capdepont, S., Londos-Gagliardi, D., Joubert, M., Correze, P., Lafon, M.E., Guillemain, B., Fleury, H.J. AIDS Res. Hum. Retroviruses (2005) [Pubmed]
  22. Allelic frequency variations at the MDH-1 locus within Schistosoma mansoni strains from Guadeloupe (French West Indies): ecological interpretation. Théron, A., Brémond, P., Imbert-Establet, D. Comp. Biochem. Physiol., B (1989) [Pubmed]
  23. Emergence and spread in French hospitals of methicillin-resistant Staphylococcus aureus with increasing susceptibility to gentamicin and other antibiotics. Lelièvre, H., Lina, G., Jones, M.E., Olive, C., Forey, F., Roussel-Delvallez, M., Nicolas-Chanoine, M.H., Bébéar, C.M., Jarlier, V., Andremont, A., Vandenesch, F., Etienne, J. J. Clin. Microbiol. (1999) [Pubmed]
  24. A genetic study of blacks from Trinidad. Saha, N., Samuel, A.P. Hum. Hered. (1987) [Pubmed]
  25. Jamaican Sbeta+-thalassaemia: mutations and haematology. Donaldson, A., Old, J., Fisher, C., Serjeant, B.E., Serjeant, G.R. Br. J. Haematol. (2000) [Pubmed]
  26. Studies on an isolated West Indies population. III. Epidemiologic study of sensorineural hearing loss. Bois, E., Bonaïti, C., Lallemant, M., Moatti, L., Feingold, N., Mayer, F.M., Feingold, J. Neuroepidemiology. (1987) [Pubmed]
  27. High prevalence of vitiligo in lepromatous leprosy. Boisseau-Garsaud, A.M., Vezon, G., Helenon, R., Garsaud, P., Saint-Cyr, I., Quist, D. International journal of dermatology. (2000) [Pubmed]
  28. Complementary medicine seminar for medical undergraduates at the University of the West Indies, Mona. Desai, P. The West Indian medical journal. (2002) [Pubmed]
  29. Prostate cancer at the University Hospital of the West Indies in Jamaica. A clinico-pathological profile at the time of needle biopsy diagnosis. Coard, K.C. The West Indian medical journal. (2002) [Pubmed]
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