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Gene Review

Scl22  -  Serum cholesterol level QTL 22

Rattus norvegicus

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Disease relevance of Scl22


High impact information on Scl22

  • Il-4 therapy prevents the development of proteinuria in active Heymann nephritis by inhibition of Tc1 cells [1].
  • Analysis of the translated amino acid sequence indicates that the Tc-1 gene has a putative transmembrane domain with multiple cytoplasmic and extracellular CKII phosphosites [2].
  • Exogenous human CKII was able to phosphorylate serine residues on both recombinant Tc-1 and Tc-1 of intact trypomastigotes [2].
  • At the amino acid level, Tc-1 displayed 95% and 99% identity to two hypothetical proteins recently reported by the T. cruzi genome project [2].
  • Upon mercury recall, CD8+ CD45RC(high) T cells, that represent the Tc1 subset in the rat, expanded and were polarized towards IFNgamma production [3].

Biological context of Scl22

  • We report here that resistance to mercury disease is long lasting and not mercury-specific, suggesting that different CD8+ T cells are involved in resistance and neonatal tolerance, and that regulatory CD8+ Tc1 cells generated in tolerance are required to control the CD8- cell population from developing Th2-mediated autoimmunity [3].
  • Tc maintained bone formation indices almost at Ova level, and only decreased mineral apposition rate (MAR) in Tc1 group, and declined bone resorption perimeter [5].

Anatomical context of Scl22

  • A rat B cell hybridoma was established from a Wistar/Furth (WF) rat immunized with the syngeneic lymphoma G1-Tc1 producing an immunoglobulin (Ig)G2c monoclonal antibody (MoAb) 1F2 [4].

Associations of Scl22 with chemical compounds

  • METHODS: Forty 3-month-old rats were randomly divided into 5 groups: sham group, Ova group, Tc1 group (1.2 mg/kg/d), Tc2 group (4.8 mg/kg/d), and estrone group (1.48 mg/kg/d), oral fed for 3 months [5].

Analytical, diagnostic and therapeutic context of Scl22


  1. Il-4 therapy prevents the development of proteinuria in active Heymann nephritis by inhibition of Tc1 cells. Spicer, S.T., Ha, H., Boyd, R.A., He, X.Y., Carter, N., Tran, G., Penny, M.J., Hodgkinson, S.J., Hall, B.M. J. Immunol. (2001) [Pubmed]
  2. Molecular cloning of a Trypanosoma cruzi cell surface casein kinase II substrate, Tc-1, involved in cellular infection. Augustine, S.A., Kleshchenko, Y.Y., Nde, P.N., Pratap, S., Ager, E.A., Burns, J.M., Lima, M.F., Villalta, F. Infect. Immun. (2006) [Pubmed]
  3. Neonatal tolerance to a Th2-mediated autoimmune disease generates CD8+ Tc1 regulatory cells. Field, A.C., Bloch, M.F., Bellon, B. J. Autoimmun. (2003) [Pubmed]
  4. Selective cytotoxicity of two rodent T cell lymphomas to rat yolk sac tumours involves a retroviral envelope protein expressed by the lymphoma. Lindvall, M., Eriksson, H., Hedlund, G., Sjögren, H.O. Scand. J. Immunol. (1997) [Pubmed]
  5. Effects of low doses of hydrochloride tetracycline on bone metabolism and uterus in ovariectomized rats. Li, Q.N., Hu, B., Huang, L.F., Chen, Y., Weng, L.L., Zheng, H., Chen, H.Q. Acta Pharmacol. Sin. (2003) [Pubmed]
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