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MeSH Review

Rats, Inbred WF

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Disease relevance of Rats, Inbred WF


High impact information on Rats, Inbred WF


Chemical compound and disease context of Rats, Inbred WF


Biological context of Rats, Inbred WF


Anatomical context of Rats, Inbred WF


Associations of Rats, Inbred WF with chemical compounds

  • Inhibitory effect of antiestrogen on hepatic tumorigenesis in WF rats treated with diethylstilbestrol alone or in combination with N-nitrosobutylurea [25].
  • Induction of hepatic tumors by diethylstilbestrol alone or in synergism with n-nitrosobutylurea in castrated male WF rats [26].
  • This study examines the direct effect of serum taken from MtTW10-bearing WF rats (MtT serum) and of substances that increase cellular levels of cyclic AMP (cAMP) on DNA synthesis in organ-cultured MTW9 [27].
  • METHODS AND RESULTS: Heterotopic rat cardiac allografts were performed from the DA to the WF rat strain, and the recipients were immunosuppressed with cyclosporine A 2 s.c. for a period of 90 days until the end of experiment [28].
  • The daily subcutaneous administration of (dichloromethylene)diphosphonate (clodronate) to 3-day-old normal inbred Wistar-Furth rats for 30 days produces osteopetrotic bone lesions resembling those of the osteopetrotic mutants [29].

Gene context of Rats, Inbred WF

  • The Pro1176 to Thr substitution found in talin from Wistar-Furth rats does not destroy the capacity of this region of the protein to bind actin or vinculin [30].
  • We compared pulmonary MT expression in Wistar Furth (WF) rats with that in DBA and C57 mice, following a single 3-h exposure to CdO fumes containing 1 mg Cd/m3 [31].
  • To further evaluate a role for IFN-gamma, we injected recombinant rat IFN-gamma (rrIFN-gamma) at the time of immunization with AChR in complete Freund's adjuvant to EAMG-susceptible Lewis rats and EAMG-resistant Wistar Furth (WF) rats [32].
  • In contrast, WF rats exhibited elevated baseline and maintained post-A/I total NO production, with no decrease in renal cortex NOS activity despite a decrease in remnant neuronal NOS abundance [33].
  • RESULTS: In glomeruli isolated from adrenalectomized Wistar rats with intact renal mass, aldosterone stimulated a threefold increase in citrate synthase activity; this stimulation was not observed in glomeruli from Wistar-Furth rats [34].

Analytical, diagnostic and therapeutic context of Rats, Inbred WF


  1. Effects of 17 beta-estradiol and diethylstilbestrol on concurrent development of hepatic, mammary, and pituitary tumors in WF rats: evidence for differential effect on liver. Sumi, C., Yokoro, K., Matsushima, R. J. Natl. Cancer Inst. (1984) [Pubmed]
  2. Inhibitory effect of phenobarbital on the development of gliomas in WF rats treated neonatally with N-ethyl-N-nitrosourea. Naito, M., Aoyama, H., Ito, A. J. Natl. Cancer Inst. (1985) [Pubmed]
  3. Adenovirus type 9-induced tumorigenesis in the rat mammary gland related to sex hormonal state. Ankerst, J., Jonsson, N. J. Natl. Cancer Inst. (1989) [Pubmed]
  4. Genetics of susceptibility of rats to trigeminal schwannomas induced by neonatal administration of N-ethyl-N-nitrosourea. Naito, M., Ito, A., Aoyama, H. J. Natl. Cancer Inst. (1985) [Pubmed]
  5. Preferential binding of radiolabeled poly-L-lysines to C6 and U87 MG glioblastomas compared with endothelial cells in vitro. Kornguth, S.E., Kalinke, T., Robins, H.I., Cohen, J.D., Turski, P. Cancer Res. (1989) [Pubmed]
  6. Induction of myocardial nitric oxide synthase by cardiac allograft rejection. Yang, X., Chowdhury, N., Cai, B., Brett, J., Marboe, C., Sciacca, R.R., Michler, R.E., Cannon, P.J. J. Clin. Invest. (1994) [Pubmed]
  7. Inhibition by 3-amino-1H-1,2,4-triazole of hepatic tumorigenesis induced by diethylstilbestrol alone or combined with N-nitrosobutylurea in WF rats. Sumi, C., Yokoro, K., Matsushima, R. J. Natl. Cancer Inst. (1985) [Pubmed]
  8. Passive transfer of diabetes from BB/W to Wistar-Furth rats. Koevary, S.B., Williams, D.E., Williams, R.M., Chick, W.L. J. Clin. Invest. (1985) [Pubmed]
  9. Effects of specific active immunization on tumor recurrence following primary tumor resection in WF rats with 1,2-dimethylhydrazine-induced bowel cancer. Ross, D.S., Steele, G., Madara, J., Lahey, S.J., Ravikumar, T.S., Wilson, R.E., Munroe, A.E., Wright, D., King, V.P. J. Natl. Cancer Inst. (1984) [Pubmed]
  10. Vasopressin response in collecting ducts of rats resistant to mineralocorticoid hypertension. Jeffries, W.B., McArdle, S., Bockman, C., Abel, P.W., Pettinger, W.A. Hypertension (1991) [Pubmed]
  11. Mitochondrial respiratory function and antioxidant capacity in normal and cirrhotic livers following partial hepatectomy. Yang, S., Tan, T.M., Wee, A., Leow, C.K. Cell. Mol. Life Sci. (2004) [Pubmed]
  12. Effect of progesterone pretreatment on cadmium toxicity in male Fischer (F344/NCr) and Wistar (WF/NCr) rats. Shiraishi, N., Barter, R.A., Uno, H., Waalkes, M.P. Environ. Health Perspect. (1994) [Pubmed]
  13. Characterization of coronavirus JHM variants isolated from Wistar Furth rats with a viral-induced demyelinating disease. Morris, V.L., Tieszer, C., Mackinnon, J., Percy, D. Virology (1989) [Pubmed]
  14. TCV-116 inhibits renal interstitial and glomerular injury in glomerulosclerotic rats. Shibouta, Y., Chatani, F., Ishimura, Y., Sanada, T., Ohta, M., Inada, Y., Nishikawa, K. Kidney Int. Suppl. (1996) [Pubmed]
  15. Quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in the rat. Tanuma, J., Shisa, H., Hiai, H., Higashi, S., Yamada, Y., Kamoto, T., Hirayama, Y., Matsuuchi, H., Kitano, M. Cancer Res. (1998) [Pubmed]
  16. Unaltered class II histocompatibility antigens and pathogenesis of IDDM in BB rats. Holowachuk, E.W., Greer, M.K. Diabetes (1989) [Pubmed]
  17. An alternatively spliced form of Pit-1 represses prolactin gene expression. Day, R.N., Day, K.H. Mol. Endocrinol. (1994) [Pubmed]
  18. Long-term survival of donor-specific pancreatic islet xenografts in fully xenogeneic chimeras (WF rat----B10 mouse). Zeng, Y.J., Ricordi, C., Tzakis, A., Rilo, H.L., Carroll, P.B., Starzl, T.E., Ildstad, S.T. Transplantation (1992) [Pubmed]
  19. Differential pulmonary vascular effects of streptozotocin diabetes in male and female rats. Russ, R.D., Tobin, B.W. Proc. Soc. Exp. Biol. Med. (1998) [Pubmed]
  20. Androgen control of cytosol progesterone receptor levels in the MT-W9B transplantable mammary tumor in the rat. Ip, M.M., Milholland, R.J., Kim, U., Rosen, F. J. Natl. Cancer Inst. (1982) [Pubmed]
  21. The relationship between glucagon receptors and metabolic profile in two strains of rats: Wistar-Furth and Sprague-Dawley. Dunbar, J.C., Wider, M., Dixon, S., Tobkin, M. Proc. Soc. Exp. Biol. Med. (1987) [Pubmed]
  22. Treatment of hyperthermia-induced extravasation with hypertonic saline (7.5%) in 6% dextran 70 (HSD) in Wistar/Furth rats. Matthew, C.B., Sils, I.V. Shock (2001) [Pubmed]
  23. Strain difference of susceptibility to 4-nitroquinoline 1-oxide-induced tongue carcinoma in rats. Kitano, M., Hatano, H., Shisa, H. Jpn. J. Cancer Res. (1992) [Pubmed]
  24. Comparison of inflammatory lung responses in Wistar rats and C57 and DBA mice following acute exposure to cadmium oxide fumes. McKenna, I.M., Waalkes, M.P., Chen, L.C., Gordon, T. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  25. Inhibitory effect of antiestrogen on hepatic tumorigenesis in WF rats treated with diethylstilbestrol alone or in combination with N-nitrosobutylurea. Sumi, C., Yokoro, K., Matsushima, R. J. Natl. Cancer Inst. (1984) [Pubmed]
  26. Induction of hepatic tumors by diethylstilbestrol alone or in synergism with n-nitrosobutylurea in castrated male WF rats. Sumi, C., Yokoro, K., Matsushima, R. J. Natl. Cancer Inst. (1983) [Pubmed]
  27. Hormone, serum, and methylxanthine interactions in the regulation of DNA synthesis in organ-cultured rat mammary tumors. Mayer, R.M., Diamond, E.J., Hollander, V.P. J. Natl. Cancer Inst. (1980) [Pubmed]
  28. Cytomegalovirus infection-enhanced cardiac allograft vasculopathy is abolished by DHPG prophylaxis in the rat. Lemström, K., Sihvola, R., Bruggeman, C., Häyry, P., Koskinen, P. Circulation (1997) [Pubmed]
  29. (Dichloromethylene)diphosphonate-induced impairment of T-lymphocyte function. Milhaud, G., Labat, M.L., Moricard, Y. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  30. Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site. Hemmings, L., Rees, D.J., Ohanian, V., Bolton, S.J., Gilmore, A.P., Patel, B., Priddle, H., Trevithick, J.E., Hynes, R.O., Critchley, D.R. J. Cell. Sci. (1996) [Pubmed]
  31. Expression of metallothionein protein in the lungs of Wistar rats and C57 and DBA mice exposed to cadmium oxide fumes. McKenna, I.M., Gordon, T., Chen, L.C., Anver, M.R., Waalkes, M.P. Toxicol. Appl. Pharmacol. (1998) [Pubmed]
  32. Role for interferon-gamma in rat strains with different susceptibility to experimental autoimmune myasthenia gravis. Wang, H.B., Shi, F.D., Li, H., van der Meide, P.H., Ljunggren, H.G., Link, H. Clin. Immunol. (2000) [Pubmed]
  33. Protection of wistar furth rats from chronic renal disease is associated with maintained renal nitric oxide synthase. Erdely, A., Wagner, L., Muller, V., Szabo, A., Baylis, C. J. Am. Soc. Nephrol. (2003) [Pubmed]
  34. Potential importance of glomerular citrate synthase activity in remnant nephropathy. Ullian, M.E., Gantt, B.J., Ford, A.K., Tholanikunnel, B.G., Spicer, E.K., Fitzgibbon, W.R. Kidney Int. (2003) [Pubmed]
  35. Formation and removal of (guan-8-yl)-DNA-2-acetylaminofluorene adducts in liver and kidney of male rats given dietary 2-acetylaminofluorene. Poirier, M.C., True, B., Laishes, B.A. Cancer Res. (1982) [Pubmed]
  36. Crosstalk of endothelin-1 and platelet-derived growth factor in cardiac allograft arteriosclerosis. Sihvola, R.K., Pulkkinen, V.P., Koskinen, P.K., Lemström, K.B. J. Am. Coll. Cardiol. (2002) [Pubmed]
  37. Role of citrate synthase in aldosterone-mediated sodium reabsorption. Ullian, M.E., Robinson, C.J., Evans, C.T., Melnick, J.Z., Fitzgibbon, W.R. Hypertension (2000) [Pubmed]
  38. Cloning, genetic mapping and expression studies of the rat Brca1 gene. Chen, K.S., Shepel, L.A., Haag, J.D., Heil, G.M., Gould, M.N. Carcinogenesis (1996) [Pubmed]
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