Chemical Compound Review:
Zlllal benzylN-[3-methyl-1-[[3- methyl-1-[[(2S)-4...
Synonyms:
Zlll-cho, Z-LLL, CHEMBL388078, Lll cpd, LS-172868, ...
- Yersinia enterocolitica impairs activation of transcription factor NF-kappaB: involvement in the induction of programmed cell death and in the suppression of the macrophage tumor necrosis factor alpha production. Ruckdeschel, K., Harb, S., Roggenkamp, A., Hornef, M., Zumbihl, R., Köhler, S., Heesemann, J., Rouot, B. J. Exp. Med. (1998)
- The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechanism. Dasmahapatra, G., Rahmani, M., Dent, P., Grant, S. Blood (2006)
- Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor. Hellerbrand, C., Jobin, C., Iimuro, Y., Licato, L., Sartor, R.B., Brenner, D.A. Hepatology (1998)
- Comparative selectivity and specificity of the proteasome inhibitors BzLLLCOCHO, PS-341, and MG-132. Crawford, L.J., Walker, B., Ovaa, H., Chauhan, D., Anderson, K.C., Morris, T.C., Irvine, A.E. Cancer Res. (2006)
- Pro-caspase-3 overexpression sensitises ovarian cancer cells to proteasome inhibitors. Tenev, T., Marani, M., McNeish, I., Lemoine, N.R. Cell Death Differ. (2001)
- Isolation, characterization, and genetic complementation of a cellular mutant resistant to retroviral infection. Agarwal, S., Harada, J., Schreifels, J., Lech, P., Nikolai, B., Yamaguchi, T., Chanda, S.K., Somia, N.V. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis. Zhang, Q., Nottke, A., Goodman, R.H. Proc. Natl. Acad. Sci. U.S.A. (2005)
- NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling. Kreuz, S., Siegmund, D., Scheurich, P., Wajant, H. Mol. Cell. Biol. (2001)
- Proteasome inhibitor MG-132 induces dopaminergic degeneration in cell culture and animal models. Sun, F., Anantharam, V., Zhang, D., Latchoumycandane, C., Kanthasamy, A., Kanthasamy, A.G. Neurotoxicology (2006)
- Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. Guzman, M.L., Neering, S.J., Upchurch, D., Grimes, B., Howard, D.S., Rizzieri, D.A., Luger, S.M., Jordan, C.T. Blood (2001)
- Prevention of brefeldin A-induced resistance to teniposide by the proteasome inhibitor MG-132: involvement of NF-kappaB activation in drug resistance. Lin, Z.P., Boller, Y.C., Amer, S.M., Russell, R.L., Pacelli, K.A., Patierno, S.R., Kennedy, K.A. Cancer Res. (1998)
- Distinct protein kinase C isoforms mediate regulation of vascular endothelial growth factor expression by A2A adenosine receptor activation and phorbol esters in pheochromocytoma PC12 cells. Gardner, A.M., Olah, M.E. J. Biol. Chem. (2003)
- 15-deoxy-delta12,14-prostaglandin J2 inhibits Bay 11-7085-induced sustained extracellular signal-regulated kinase phosphorylation and apoptosis in human articular chondrocytes and synovial fibroblasts. Relic, B., Benoit, V., Franchimont, N., Ribbens, C., Kaiser, M.J., Gillet, P., Merville, M.P., Bours, V., Malaise, M.G. J. Biol. Chem. (2004)
- Evidence for involvement of the proteasome complex (26S) and NFkappaB in IL-1beta-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells. Kwon, G., Corbett, J.A., Hauser, S., Hill, J.R., Turk, J., McDaniel, M.L. Diabetes (1998)
- Proteasome inhibitor (MG-132) treatment of mdx mice rescues the expression and membrane localization of dystrophin and dystrophin-associated proteins. Bonuccelli, G., Sotgia, F., Schubert, W., Park, D.S., Frank, P.G., Woodman, S.E., Insabato, L., Cammer, M., Minetti, C., Lisanti, M.P. Am. J. Pathol. (2003)
- Involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome. Imamura, T., Haruta, T., Takata, Y., Usui, I., Iwata, M., Ishihara, H., Ishiki, M., Ishibashi, O., Ueno, E., Sasaoka, T., Kobayashi, M. J. Biol. Chem. (1998)
- Limb-girdle muscular dystrophy (LGMD-1C) mutants of caveolin-3 undergo ubiquitination and proteasomal degradation. Treatment with proteasomal inhibitors blocks the dominant negative effect of LGMD-1C mutanta and rescues wild-type caveolin-3. Galbiati, F., Volonte, D., Minetti, C., Bregman, D.B., Lisanti, M.P. J. Biol. Chem. (2000)
- Aryl hydrocarbon receptor imported into the nucleus following ligand binding is rapidly degraded via the cytosplasmic proteasome following nuclear export. Davarinos, N.A., Pollenz, R.S. J. Biol. Chem. (1999)
- The human multidrug resistance P-glycoprotein is inactive when its maturation is inhibited: potential for a role in cancer chemotherapy. Loo, T.W., Clarke, D.M. FASEB J. (1999)
- Inhibition versus induction of apoptosis by proteasome inhibitors depends on concentration. Lin, K.I., Baraban, J.M., Ratan, R.R. Cell Death Differ. (1998)
- Enac degradation in A6 cells by the ubiquitin-proteosome proteolytic pathway. Malik, B., Schlanger, L., Al-Khalili, O., Bao, H.F., Yue, G., Price, S.R., Mitch, W.E., Eaton, D.C. J. Biol. Chem. (2001)
- Bombesin stimulates nuclear factor kappa B activation and expression of proangiogenic factors in prostate cancer cells. Levine, L., Lucci, J.A., Pazdrak, B., Cheng, J.Z., Guo, Y.S., Townsend, C.M., Hellmich, M.R. Cancer Res. (2003)
- Modulation of human beta-defensin-2 transcription in pulmonary epithelial cells by lipopolysaccharide-stimulated mononuclear phagocytes via proinflammatory cytokine production. Tsutsumi-Ishii, Y., Nagaoka, I. J. Immunol. (2003)
- Oxidative stress augments the production of matrix metalloproteinase-1, cyclooxygenase-2, and prostaglandin E2 through enhancement of NF-kappa B activity in lipopolysaccharide-activated human primary monocytes. Lu, Y., Wahl, L.M. J. Immunol. (2005)
- A novel mechanism of G protein-dependent phosphorylation of vasodilator-stimulated phosphoprotein. Profirovic, J., Gorovoy, M., Niu, J., Pavlovic, S., Voyno-Yasenetskaya, T. J. Biol. Chem. (2005)
- Degradation of NFAT5, a Transcriptional Regulator of Osmotic Stress-related Genes, Is a Critical Event for Doxorubicin-induced Cytotoxicity in Cardiac Myocytes. Ito, T., Fujio, Y., Takahashi, K., Azuma, J. J. Biol. Chem. (2007)
- Inhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132. Fiedler, M.A., Wernke-Dollries, K., Stark, J.M. Am. J. Respir. Cell Mol. Biol. (1998)
- p38 MAPK and NF-kappaB mediate COX-2 expression in human airway myocytes. Singer, C.A., Baker, K.J., McCaffrey, A., AuCoin, D.P., Dechert, M.A., Gerthoffer, W.T. Am. J. Physiol. Lung Cell Mol. Physiol. (2003)
- Proteasome inhibition improves fractionated radiation treatment against non-small cell lung cancer: an antioxidant connection. Grimes, K.R., Daosukho, C., Zhao, Y., Meigooni, A., St Clair, W. Int. J. Oncol. (2005)
- Mechanism of action of superactive vitamin D analogs through regulated receptor degradation. Jääskeläinen, T., Ryhänen, S., Mahonen, A., DeLuca, H.F., Mäenpää, P.H. J. Cell. Biochem. (2000)