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Gene Review

HSP90B1  -  heat shock protein 90kDa beta (Grp94),...

Gallus gallus

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Disease relevance of HSP90B1


High impact information on HSP90B1


Biological context of HSP90B1


Anatomical context of HSP90B1


Associations of HSP90B1 with chemical compounds

  • Recent work has shown that TfBP is a post-translationally modified form of the heat shock protein (HSP108), the avian homologue of a glucose regulated protein, GRP94 [5].

Other interactions of HSP90B1


Analytical, diagnostic and therapeutic context of HSP90B1

  • The protein purified from oviduct by SDS-PAGE or from liver by ovotransferrin-affinity chromatography reacts with a monoclonal antibody raised against HSP108 [11].
  • The developmental expression of heat shock protein 108 (HSP108) mRNA was mapped in chicken brain using in situ hybridization and reverse transcription-polymerase chain reaction (RT-PCR) [12].
  • RT-PCR showed that HSP108 mRNA increased from embryonic day 5 (E5) to 13 (E13), significantly decreased from E17 to E21 and then increased again at the adult stage [12].
  • The localization of HSP108 in embryonic days 15 (E15), E18, and postnatal day 2 (P2) chick retina was examined immunohistochemically using monoclonal antibody 9G10 specific for chick HSP108, while the expression levels of HSP108 in developing chick retina from E12 to P2 and adult were measured by Western blot analysis [2].


  1. Amino acid sequence of a chicken heat shock protein derived from the complementary DNA nucleotide sequence. Kulomaa, M.S., Weigel, N.L., Kleinsek, D.A., Beattie, W.G., Conneely, O.M., March, C., Zarucki-Schulz, T., Schrader, W.T., O'Malley, B.W. Biochemistry (1986) [Pubmed]
  2. Expression profile of heat shock protein 108 during retinal development in the chick. Zhao, J., Yoneda, M., Inoue, Y., Kakizaki, H., Ohno-Jinno, A., Kataoka, T., Iwaki, M., Zako, M. Neurosci. Lett. (2006) [Pubmed]
  3. The estrogen-inducible transferrin receptor-like membrane glycoprotein is related to stress-regulated proteins. Poola, I., Kiang, J.G. J. Biol. Chem. (1994) [Pubmed]
  4. Oligodendroglia in the avian retina: immunocytochemical demonstration in the adult bird. Seo, J.H., Haam, Y.G., Park, S.W., Kim, D.W., Jeon, G.S., Lee, C., Hwang, D.H., Kim, Y.S., Cho, S.S. J. Neurosci. Res. (2001) [Pubmed]
  5. Distribution of transferrin binding protein immunoreactivity in the chicken central and peripheral nervous systems. Cho, S.S., Lucas, J.J., Roh, E.J., Yoo, Y.B., Lee, K.H., Park, K.H., Hwang, D.H., Baik, S.H. J. Comp. Neurol. (1997) [Pubmed]
  6. Heat shock protein 108 mRNA expression during chicken retina development. Shin, D.H., Kim, H.J., Kim, J., Bae, S.R., Cho, S.S. Neurosci. Lett. (2003) [Pubmed]
  7. Heat shock protein gene HSP108 and a replication histone gene cluster are linked in the chicken. Van Hest, B.J., Molloy, P.L., Frankham, R., Sheldon, B.L. Anim. Genet. (1994) [Pubmed]
  8. Distribution of heat shock protein 108 mRNA in the chicken central nervous system. Shin, D.H., Kim, H.J., Lee, H.Y., Lee, K.H., Jeon, G.S., Seo, J.H., Baik, S.H., Cho, S.S. Neurosci. Lett. (2000) [Pubmed]
  9. Binding specificity of avian heat shock protein 108. Weiner, K.X., Hayes, G.R., Lucas, J.J. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  10. Localization of transferrin binding protein in relation to iron, ferritin, and transferrin receptors in the chicken cerebellum. Cho, S.S., Shin, D.H., Lee, K.H., Hwang, D.H., Chang, K.Y. Brain Res. (1998) [Pubmed]
  11. A chicken transferrin binding protein is heat shock protein 108. Hayes, G.R., Himpler, B.S., Weiner, K.X., Lucas, J.J. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  12. Distribution of heat shock protein 108 mRNA during the development of the chicken brain. Shin, D.H., Lee, E., Kim, J., Bae, S.R., Chung, Y.H., Kim, H.J., Lee, M.H., Cho, S.S. Neurosci. Lett. (2004) [Pubmed]
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